Altered emotion regulation in obsessive-compulsive disorder as evidenced by the late positive potential
Open accessAbstract
BACKGROUND: Obsessive-compulsive disorder (OCD) is associated with marked anxiety, which triggers repetitive behaviours or mental rituals. The persistence of pathological anxiety and maladaptive strategies to reduce anxiety point to altered emotion regulation. The late positive potential (LPP) is an event-related brain potential (ERP) that reflects sustained attention to emotional stimuli and is sensitive to emotion-regulation instructions. We hypothesized that patients with OCD show altered electrocortical responses during reappraisal of stimuli triggering their symptoms. METHOD: To test our hypothesis, ERPs to disorder-relevant, generally aversive and neutral pictures were recorded while participants were instructed to either maintain or reduce emotional responding using cognitive distraction or cognitive reappraisal. RESULTS: Relative to healthy controls, patients with OCD showed enhanced LPPs in response to disorder-relevant pictures, indicating their prioritized processing. While both distraction and reappraisal successfully reduced the LPP in healthy controls, patients with OCD failed to show corresponding LPP modulation during cognitive reappraisal despite successfully reduced subjective arousal ratings. CONCLUSIONS: The results point to sustained attention towards emotional stimuli during cognitive reappraisal in OCD and suggest that abnormal emotion regulation should be integrated in models of OCD.
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
(1970) · Cited by 24,983 · see citing works
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962 · see citing works
Gross, J. J., & John, O. P. (2003) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.85.2.348 · Cited by 11,929 · cited 1× · see citing works
“Dispositional emotion regulation was measured with the Emotion Regulation Questionnaire (ERQ; Gross & John, 2003) and the Cognitive Emotion Regulation Questionnaire (CERQ; Garnefski et al. 2001).”
MethodThe Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110048007 · Cited by 7,712 · see citing works
(2005) · CTIT technical reports series · Cited by 5,307 · see citing works
Handbook of Emotion Regulation
Lambert, K. G. (2007) · JAMA · doi:10.1001/jama.298.15.1808 · Cited by 4,900 · see citing works
Gross, J. J. (1998) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.74.1.224 · Cited by 4,671 · cited 3× · see citing works
“Distraction is supposed to influence emotion generation before elaborate stimulus processing has taken place (Gross, 1998).”
BackgroundInfluentialThreat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study.
Bar-Haim, Y., Lamy, D., Pergamin, L., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.1.1 · Cited by 3,721 · see citing works
Handbook of emotion regulation
Gross, J. (2014) · Choice Reviews Online · doi:10.5860/choice.52-1127 · Cited by 3,280 · see citing works
The Obsessive-Compulsive Inventory: Development and validation of a short version.
Foa, E. B., Huppert, J. D., Leiberg, S., Langner, R., Kichic, R., Hajcak, G., & Salkovskis, P. M. (2002) · Psychological Assessment · doi:10.1037/1040-3590.14.4.485 · Cited by 2,959 · see citing works
Negative life events, cognitive emotion regulation and emotional problems
Garnefski, N., Kraaij, V, & Spinhoven, P. (2001) · Personality and Individual Differences · doi:10.1016/s0191-8869(00)00113-6 · Cited by 2,494 · see citing works
Obsessional-compulsive problems: A cognitive-behavioural analysis
Salkovskis, P. M. (1985) · Behaviour Research and Therapy · doi:10.1016/0005-7967(85)90105-6 · Cited by 1,842 · see citing works
Neurobiology of emotion perception II: implications for major psychiatric disorders
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00171-9 · Cited by 1,736 · see citing works
Emotion regulation and mental health
Gross, J. J., & Muñoz, R. F. (1995) · Clinical Psychology: Science and Practice · doi:10.1111/j.1468-2850.1995.tb00036.x · Cited by 1,595 · see citing works
Event-Related Potentials, Emotion, and Emotion Regulation: An Integrative Review
Hajcak, G., MacNamara, A., & Olvet, D. M. (2010) · Developmental Neuropsychology · doi:10.1080/87565640903526504 · Cited by 1,370 · see citing works
Encoding Predictive Reward Value in Human Amygdala and Orbitofrontal Cortex
Gottfried, J. A., O'Doherty, J., & Dolan, R. J. (2003) · Science · doi:10.1126/science.1087919 · Cited by 1,165 · see citing works
Ventromedial prefrontal–subcortical systems and the generation of affective meaning
Roy, M., Shohamy, D., & Wager, T. D. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.01.005 · Cited by 856 · see citing works
Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways
Milad, M. R., & Rauch, S. L. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.11.003 · Cited by 847 · see citing works
Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder
Saxena, S., & Rauch, S. L. (2000) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70181-7 · Cited by 840 · see citing works
Emotion regulation and mental health: recent findings, current challenges, and future directions
Berking, M., & Wupperman, P. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283503669 · Cited by 836 · see citing works
Neuroimaging and frontal–subcortical circuitry in obsessive–compulsive disorder
Saxena, S., Brody, A. L., Schwartz, J. M., & Baxter, L. R. (1998) · British Journal of Psychiatry · doi:10.1192/s0007125000297870 · Cited by 831 · see citing works
Obsessive-compulsive disorder: An integrative genetic and neurobiological perspective
Pauls, D. L., Abramovitch, A., Rauch, S. L., & Geller, D. A. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3746 · Cited by 793 · see citing works
A multiple source approach to the correction of eye artifacts
Berg, P., & Scherg, M. (1994) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(94)90094-9 · Cited by 696 · see citing works
Fellows, L. K. (2003) · Brain · doi:10.1093/brain/awg180 · Cited by 631 · see citing works
Reappraisal modulates the electrocortical response to unpleasant pictures
Hajcak, G., & Nieuwenhuis, S. (2006) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.6.4.291 · Cited by 613 · see citing works
How to Regulate Emotion? Neural Networks for Reappraisal and Distraction
Kanske, P., Heissler, J., Schönfelder, S., Bongers, A., & Wessa, M. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq216 · Cited by 589 · see citing works
Unpacking cognitive reappraisal: Goals, tactics, and outcomes.
Kateri Mcrae, A., Ciesielski, B. G., & Gross, J. J. (2011) · Emotion · doi:10.1037/a0026351 · Cited by 515 · see citing works
Brain processes in emotional perception: Motivated attention
Schupp, H. T., Cuthbert, B. N., Bradley, M. M., Hillman, C. H., Hamm, A. O., & Lang, P. J. (2004) · Cognition & Emotion · doi:10.1080/02699930341000239 · Cited by 508 · see citing works
Goldin, P. R., Manber, T., Hakimi, S., Canli, T., & Gross, J. J. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.525 · Cited by 486 · see citing works
The temporal dynamics of emotion regulation: An EEG study of distraction and reappraisal
Thiruchselvam, R., Blechert, J., Sheppes, G., Rydstrom, A., & Gross, J. J. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.02.009 · Cited by 431 · see citing works
Beyond good and evil: The time-course of neural activity elicited by specific picture content.
Weinberg, A., & Hajcak, G. (2010) · Emotion · doi:10.1037/a0020242 · Cited by 425 · see citing works
Neural Substrate of the Late Positive Potential in Emotional Processing
Liu, Y., Huang, H., Deweese, M. M., Keil, A., & Ding, M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3109-12.2012 · Cited by 415 · see citing works
Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder
Remijnse, P. L., Nielen, M. M. A., van Balkom, A. J. L. M., Cath, D. C., van Oppen, P., Uylings, H. B. M., & Veltman, D. J. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1225 · Cited by 408 · see citing works
Tanaka-Matsumi, J., & Kameoka, V. (1986) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.54.3.328 · Cited by 408 · see citing works
Cognitive-Behavioral Therapy for OCD
Clark, D. A. (2003) · Cited by 385 · see citing works
Prefrontal mechanisms of behavioral flexibility, emotion regulation and value updating
Rudebeck, P. H., Saunders, R. C., Prescott, A. T., Chau, L. S., & Murray, E. A. (2013) · Nature Neuroscience · doi:10.1038/nn.3440 · Cited by 383 · see citing works
Tanaka‐Matsumi, J., & Kameoka, V. A. (1986) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.54.3.328 · Cited by 376 · see citing works
Dörfel, D., Lamke, J.-P., Hummel, F., Wagner, U., Erk, S., & Walter, H. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.06.051 · Cited by 322 · see citing works
(2007) · Cited by 320 · see citing works
Adler, C. M., McDonough-Ryan, P., Sax, K. W., Holland, S. K., Arndt, S., & Strakowski, S. M. (2000) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(00)00022-4 · Cited by 313 · see citing works
Neural correlates of rapid reversal learning in a simple model of human social interaction
Kringelbach, M. L., & Rolls, E. T. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00393-8 · Cited by 306 · see citing works
Abnormally high degree connectivity of the orbitofrontal cortex in obsessive-compulsive disorder
Beucke, J. C., Sepulcre, J., Talukdar, T., Linnman, C., Zschenderlein, K., Endrass, T., Kaufmann, C., & Kathmann, N. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.173 · Cited by 280 · see citing works
Self-citationMurray, E. A., O'Doherty, J. P., & Schoenbaum, G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1556-07.2007 · Cited by 238 · see citing works
Prefrontal dysfunction during emotion regulation in generalized anxiety and panic disorders
Ball, T. M., Ramsawh, H. J., Campbell-Sills, L., Paulus, M. P., & Stein, M. B. (2013) · Psychological Medicine · doi:10.1017/s0033291712002383 · Cited by 212 · see citing works
Sabatinelli, D., Keil, A., Frank, D. W., & Lang, P. J. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.04.005 · Cited by 212 · see citing works
Moser, J. S., Krompinger, J. W., Dietz, J., & Simons, R. F. (2008) · Psychophysiology · doi:10.1111/j.1469-8986.2008.00721.x · Cited by 186 · see citing works
Obsessive-Compulsive and Related Disorders: A Critical Review of the New Diagnostic Class
Abramowitz, J. S., & Jacoby, R. J. (2015) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032813-153713 · Cited by 185 · see citing works
Neural Mechanisms of Automatic and Direct Processing of Phobogenic Stimuli in Specific Phobia
Straube, T., Mentzel, H., & Miltner, W. H. R. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.013 · Cited by 184 · see citing works
Kanske, P., Heissler, J., Schönfelder, S., & Wessa, M. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.089 · Cited by 175 · see citing works
REMIJNSE, P., NIELEN, M., UYLINGS, H., & VELTMAN, D. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.009 · Cited by 163 · see citing works
Neuroimaging in anxiety disorders
Holzschneider, K., & Mulert, C. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.4/kholzschneider · Cited by 146 · see citing works
Time course of emotion-related responding during distraction and reappraisal
Schönfelder, S., Kanske, P., Heissler, J., & Wessa, M. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst116 · Cited by 143 · see citing works
Simon, D., Kaufmann, C., Müsch, K., Kischkel, E., & Kathmann, N. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2010.00980.x · Cited by 135 · see citing works
Self-citationTiming effects of antecedent- and response-focused emotion regulation strategies
Paul, S., Simón, D., Kniesche, R., Kathmann, N., & Endraß, T. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.05.019 · Cited by 135 · see citing works
Self-citationRemijnse, P. L., Nielen, M. M. A., van Balkom, A. J. L. M., Hendriks, G.-J., Hoogendijk, W. J., Uylings, H. B. M., & Veltman, D. J. (2009) · Psychological Medicine · doi:10.1017/s0033291708005072 · Cited by 127 · see citing works
Emotion regulation in spider phobia: role of the medial prefrontal cortex
Hermann, A., Schäfer, A., Walter, B., Stark, R., Vaitl, D., & Schienle, A. (2009) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsp013 · Cited by 125 · cited 1× · see citing works
“Further, during emotion regulation, reduced activity in prefrontal areas involved in the cognitive control of emotions has been shown for social anxiety disorder (Goldin et al. 2009), generalized anxiety and panic disorder (Ball et al. 2013) and spider phobia (Hermann et al. 2009).”
BackgroundExperiential avoidance and emotion regulation difficulties in hoarding disorder
Fernández de la Cruz, L., Landau, D., Iervolino, A. C., Santo, S., Pertusa, A., Singh, S., & Mataix-Cols, D. (2013) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2013.01.004 · Cited by 124 · see citing works
Kret, M. E., & Ploeger, A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.02.011 · Cited by 115 · see citing works
Anxiety and spatial attention moderate the electrocortical response to aversive pictures
MacNamara, A., & Hajcak, G. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.06.026 · Cited by 112 · see citing works
Brain dynamics in spider-phobic individuals exposed to phobia-relevant and other emotional stimuli.
Michałowski, J. M., Melzig, C. A., Weike, A. I., Stockburger, J., Schupp, H. T., & Hamm, A. O. (2009) · Emotion · doi:10.1037/a0015550 · Cited by 104 · see citing works
Simon, D., Adler, N., Kaufmann, C., & Kathmann, N. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2014.03.011 · Cited by 102 · see citing works
Self-citationAn event-related potential study on exposure therapy for patients suffering from spider phobia
Leutgeb, V., Schäfer, A., & Schienle, A. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.09.003 · Cited by 95 · see citing works
Electrophysiological correlates of threat processing in spider phobics.
Kolassa, I., Musial, F., Mohr, A., Trippe, R. H., & Miltner, W. (2005) · Psychophysiology · doi:10.1111/j.1469-8986.2005.00315.x · Cited by 95 · see citing works
Recent Advances in Research on Cognition and Emotion in OCD: A Review
Calkins, A. W., Berman, N. C., & Wilhelm, S. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0357-4 · Cited by 94 · see citing works
Attention and amygdala activity: an fMRI study with spider pictures in spider phobia
Alpers, G. W., Gerdes, A. B. M., Lagarie, B., Tabbert, K., Vaitl, D., & Stark, R. M. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0106-8 · Cited by 62 · see citing works
Thiruchselvam (2012) · doi:10.1177/0956797612449838 · Cited by 56 · see citing works
Wiens, S., & Syrjänen, E. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.05.001 · Cited by 49 · see citing works
Schienle, A., Schäfer, A., & Naumann, E. (2008) · Journal of Psychophysiology · doi:10.1027/0269-8803.22.1.5 · Cited by 46 · see citing works
Aversive picture processing: Effects of a concurrent task on sustained defensive system engagement
Wangelin, B. C., Löw, A., McTeague, L. M., Bradley, M. M., & Lang, P. J. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2010.01041.x · Cited by 37 · see citing works
Frontal late positivity in dental phobia: A study on gender differences
Schienle, A., Köchel, A., & Leutgeb, V. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.08.010 · Cited by 35 · see citing works
Simón, D., Kischkel, E., Spielberg, R., & Kathmann, N. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.12.022 · Cited by 35 · see citing works
Self-citationNorberg, J., Peira, N., & Wiens, S. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2010.01019.x · Cited by 28 · see citing works
Leutgeb, V., Schäfer, A., & Schienle, A. (2011) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2011.01.003 · Cited by 27 · see citing works
Amygdala activation to threat under attentional load in individuals with anxiety disorder
Straube, T., Lipka, J., Sauer, A., Mothes‐Lasch, M., & Miltner, W. H. R. (2011) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-1-12 · Cited by 16 · see citing works
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- Authors
- Paul, S., Simon, D., Endrass, T., & Kathmann, N.
- Affiliations
- Humboldt-Universität zu Berlin (DE)
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2015-09-15
- Volume
- 46
- Issue
- 1
- Pages
- 137-147
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2271210283
- Cited by
- 60
- References
- 75
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 6 · 2023: 8 · 2022: 11 · 2021: 2 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 5
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- edoc Publication server (Humboldt University of Berlin) (submittedVersion)
- edoc Publication server (Humboldt University of Berlin)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- obsessive-compulsive disorder, emotion regulation, late positive potential, cognitive reappraisal, cognitive distraction, anxiety, event-related potentials, subjective arousal, emotional picture processing
- MeSH terms
- Self-Control, Adult, Attention, Electroencephalography, Emotions, Evoked Potentials, Female, Humans, Male, Obsessive-Compulsive Disorder
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