Cited by 187Retinal Diseases and TreatmentsOcular Diseases and Behçet’s SyndromeRetinal Development and Disorders

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On phagocytes and macular degeneration

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Guillonneau, Xavier, Eandi, Chiara M., Paques, Michel, Sahel, José-Alain, Sapieha, Przemyslaw, Sennlaub, Florian·2017·Progress in Retinal and Eye Research

DOI 10.1016/j.preteyeres.2017.06.002

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Abstract

Age related macular degeneration (AMD) is a complex multifactorial disease caused by the interplay of age and genetic and environmental risk factors. A common feature observed in early and both forms of late AMD is the breakdown of the physiologically immunosuppressive subretinal environment and the protracted accumulation of mononuclear phagocytes (MP). We here discuss the origin and nature of subretinal MPs, the mechanisms that lead to their accumulation, the inflammatory mediators they produce as well as the consequences of their chronic presence on photoreceptors, retinal pigment epithelium and choroid. Recent advances highlight how both genetic and environmental risk factors directly promote subretinal inflammation and tip the balance from a beneficial inflammation that helps control debris accumulation to detrimental chronic inflammation and destructive late AMD. Finally, we discuss how changes in life style or pharmacological intervention can help to break the vicious cycle of inflammation and degeneration, restore the immunosuppressive properties of the subretinal space, and reestablish homeostasis.

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Items 201–394 of 394

Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo
Roselaar, S. E., & Daugherty, A. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32160-x · Cited by 193
Impairments in Dark Adaptation Are Associated with Age-Related Macular Degeneration Severity and Reticular Pseudodrusen
Flamendorf, J., Agrón, E., Wong, W. T., Thompson, D. J. S., Wiley, H. E., Doss, E. L., Al‐Holou, S. N., Ferris, F. L., Chew, E. Y., & Cukras, C. A. (2015) · Ophthalmology · doi:10.1016/j.ophtha.2015.06.023 · Cited by 192
Impaired Binding of the Age-related Macular Degeneration-associated Complement Factor H 402H Allotype to Bruch's Membrane in Human Retina
Clark, S. J., Perveen, R., Hakobyan, S., Morgan, B. P., Sim, R. B., Bishop, P. N., & Day, A. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.103986 · Cited by 189
Immunobiology and privilege of neuronal retina and pigment epithelium transplants
Streilein, J. W., Ma, N., Wenkel, H., Ng, T. F., & Zamiri, P. (2002) · Vision Research · doi:10.1016/s0042-6989(01)00185-7 · Cited by 187
Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE ε4/ε4 genotype accelerates HIV disease progression
Burt, T., Agan, B., Marconi, V., He, W., Kulkarni, H., Mold, J. E., Cavrois, M., Huang, Y.-D., Mahley, R., Dolan, M., et al. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0803526105 · Cited by 185
His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form
Clark, S. J., Higman, V. A., Mulloy, B., Perkins, S. J., Lea, S. M., Sim, R. B., & Day, A. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605083200 · Cited by 185
Risk of Age-Related Macular Degeneration in Eyes With Macular Drusen or Hyperpigmentation
Wang, J. J. (2003) · Archives of Ophthalmology · doi:10.1001/archopht.121.5.658 · Cited by 182
Photoreceptor Proteins Initiate Microglial Activation via Toll-like Receptor 4 in Retinal Degeneration Mediated by All-trans-retinal
Kohno, H., Chen, Y., Kevany, B. M., Pearlman, E. M., Miyagi, M., Maeda, T., Palczewski, K., & Maeda, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.448712 · Cited by 180
Identification of a rare coding variant in complement 3 associated with age-related macular degeneration
Zhan, X., Larson, D. E., Wang, C., Koboldt, D. C., Sergeev, Y. V., Fulton, R. S., Fulton, L., Fronick, C. C., Branham, K. E. H., Bragg‐Gresham, J. L., et al. (2013) · Nature Genetics · doi:10.1038/ng.2758 · Cited by 179
Monocyte Activation in Patients With Age-Related Macular Degeneration
Cousins, S. W. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.7.1013 · Cited by 178
Putting cholesterol in its place: apoE and reverse cholesterol transport
Mahley, R. W. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28632 · Cited by 173
Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits
Swaroop, A., Branham, K. E., Chen, W., & Abecasis, G. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm212 · Cited by 173
Mapping of the domains required for decay acceleration activity of the human factor H‐like protein 1 and factor H
Kühn, S., & Zipfel, P. F. (1996) · European Journal of Immunology · doi:10.1002/eji.1830261017 · Cited by 168
Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation
Calippe, B., Augustin, S., Beguier, F., Charles-Messance, H., Poupel, L., Conart, J.-B., Hu, S. J., Lavalette, S., Fauvet, A., Rayes, J., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.01.006 · Cited by 168
Self-citation
The Relation of Cardiovascular Disease and Its Risk Factors to the 5-year Incidence of Age-related Maculopathy
Klein, R., Klein, R., & Jensen, S. C. (1997) · Ophthalmology · doi:10.1016/s0161-6420(97)30023-2 · Cited by 167
Molecular composition of drusen as related to substructural phenotype.
Hageman, G. S., & Mullins, R. F. (1999) · PubMed · Cited by 167
Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina
White, D. T., Sengupta, S., Saxena, M. T., Xu, Q., Hanes, J. S., Ding, D., Ji, H., & Mumm, J. S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617721114 · Cited by 167
Spinal Cord Injury Elicits Expression of Keratan Sulfate Proteoglycans by Macrophages, Reactive Microglia, and Oligodendrocyte Progenitors
Jones, L. L., & Tuszynski, M. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04611.2002 · Cited by 166
The complotype: dictating risk for inflammation and infection
Harris, C. L., Heurich, M., de Córdoba, S. R., & Morgan, B. P. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.06.001 · Cited by 166
Local apoptosis mediates clearance of macrophages from resolving inflammation in mice
Gautier, E. L., Ivanov, S., Lesnik, P., & Randolph, G. J. (2013) · Blood · doi:10.1182/blood-2013-01-478206 · Cited by 164
Factor H: A Complement Regulator in Health and Disease, and a Mediator of Cellular Interactions
Kopp, A., Hebecker, M., Svobodová, E., & Józsi, M. (2012) · Biomolecules · doi:10.3390/biom2010046 · Cited by 160
Regulation of age-related macular degeneration-like pathology by complement factor H
Toomey, C. B., Kelly, U., Saban, D. R., & Rickman, C. B. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424391112 · Cited by 157
Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization
Caicedo, A., Espinosa‐Heidmann, D. G., Piña, Y., Hernandez, E. P., & Cousins, S. W. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.01.013 · Cited by 156
Markers of Inflammation, Oxidative Stress, and Endothelial Dysfunction and the 20-Year Cumulative Incidence of Early Age-Related Macular Degeneration
Klein, R., Myers, C. E., Cruickshanks, K. J., Gangnon, R. E., Danforth, L. G., Sivakumaran, T. A., Iyengar, S. K., Tsai, M. Y., & Klein, R. (2014) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2013.7671 · Cited by 153
Interleukin-6 Receptor-Mediated Activation of Signal Transducer and Activator of Transcription-3 (STAT3) Promotes Choroidal Neovascularization
Izumi‐Nagai, K., Nagai, N., Ozawa, Y., Mihara, M., Ohsugi, Y., Kurihara, T., Koto, T., Satofuka, S., Inoue, M., Tsubota, K., et al. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061018 · Cited by 153
Monocyte Chemoattractant Protein 1, Intercellular Adhesion Molecule 1, and Vascular Cell Adhesion Molecule 1 in Exudative Age-Related Macular Degeneration
Jonas, J. B. (2010) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2010.227 · Cited by 152
Evidence of association of APOE with age-related macular degeneration - a pooled analysis of 15 studies
McKay, G. J., Patterson, C. C., Chakravarthy, U., Dasari, S., Klaver, C. C., Vingerling, J. R., Ho, L., de Jong, P. T. V. M., Fletcher, A. E., Young, I. S., et al. (2011) · Human Mutation · doi:10.1002/humu.21577 · Cited by 151
Cytomegalovirus induction of tumor necrosis factor-alpha by human monocytes and mucosal macrophages.
Smith, P. D., Saini, S. S., Raffeld, M. A., Manischewitz, J. F., & Wahl, S. M. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116035 · Cited by 148
Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids
Shaw, P. X., Zhang, L., Zhang, M., Du, H., Zhao, L., Lee, C., Grob, S., Lim, S. L., Hughes, G., Lee, J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121309109 · Cited by 148
IL-6 antagonizes TGF-beta and abolishes immune privilege in eyes with endotoxin-induced uveitis.
Ohta, K., Yamagami, S., Taylor, A. W., & Streilein, J. W. (2000) · PubMed · Cited by 147
Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age‐related macular degeneration
Levy, O., Calippe, B., Lavalette, S., Hu, S. J., Raoul, W., Dominguez, E., Housset, M., Pâques, M., Sahel, J., Bemelmans, A., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404524 · Cited by 143
Self-citation
Monocyte chemotactic protein gene expression by cytokine-treated human retinal pigment epithelial cells.
Elner, V. M., Strieter, R. M., Elner, V. M., Rollins, B. J., Monte, M. A. D., & Kunkel, S. L. (1991) · PubMed · Cited by 143
Physical activity and exercise attenuate neuroinflammation in neurological diseases
Spielman, L. J., Little, J. P., & Klegeris, A. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.03.012 · Cited by 142
Spectral-Domain Optical Coherence Tomography Characteristics of Intermediate Age-related Macular Degeneration
Leuschen, J. N., Schuman, S. G., Winter, K. P., McCall, M. N., Wong, W. T., Chew, E. Y., Hwang, T. S., Srivastava, S. K., Sarin, N., Clemons, T. E., et al. (2012) · Ophthalmology · doi:10.1016/j.ophtha.2012.07.004 · Cited by 141
Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation
Heeren, J., Grewal, T., Laatsch, A., Becker, N., Rinninger, F., Rye, K.-A., & Beisiegel, U. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409324200 · Cited by 139
Interleukin-1β Inhibition Prevents Choroidal Neovascularization and Does Not Exacerbate Photoreceptor Degeneration
Lavalette, S., Raoul, W., Houssier, M., Camelo, S., Levy, O., Calippe, B., Jonet, L., Béhar‐Cohen, F., Chemtob, S., Guillonneau, X., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.01.013 · Cited by 138
Self-citation
Light-induced migration of retinal microglia into the subretinal space.
Ng, T. F., & Streilein, J. W. (2001) · PubMed · Cited by 136
TH1 AND TH2 RESPONSES IN PATHOGENESIS AND REGULATION OF EXPERIMENTAL AUTOIMMUNE UVEORETINITIS
Caspi, R. R. (2002) · International Reviews of Immunology · doi:10.1080/08830180212063 · Cited by 135
Targeted Disruption of the CD18 or ICAM-1 Gene Inhibits Choroidal Neovascularization
Sakurai, E., Taguchi, H., Anand, A., Ambati, B. K., Gragoudas, E. S., Miller, J. W., Adamis, A. P., & Ambati, J. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-1246 · Cited by 135
Evidence that retinal pigment epithelium functions as an immune-privileged tissue.
Wenkel, H., & Streilein, J. W. (2000) · PubMed · Cited by 134
Exercise, APOE genotype, and the evolution of the human lifespan
Raichlen, D. A., & Alexander, G. E. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.03.001 · Cited by 132
1999 George Lyman Duff Memorial Lecture
Tall, A. R., Jiang, X., Luo, Y., & Silver, D. L. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.5.1185 · Cited by 130
Complement in removal of the dead – balancing inflammation
Martin, M., & Blom, A. M. (2016) · Immunological Reviews · doi:10.1111/imr.12462 · Cited by 130
The aged retinal pigment epithelium/choroid: a potential substratum for the pathogenesis of age-related macular degeneration
Chen, H., Liu, B., Lukas, T. J., & Neufeld, A. H. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002339 · Cited by 129
Patterning of the mammalian cochlea
Cantos, R., Cole, L., Acampora, D., Simeone, A., & Wu, D. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.22.11707 · Cited by 129
Apolipoprotein E polymorphism in The Netherlands and its effect on plasma lipid and apolipoprotein levels
Smit, M., de Knijff, P., Rosseneu, M., Bury, J., Klasen, E., Frants, R., & Havekes, L. (1988) · Human Genetics · doi:10.1007/bf01790099 · Cited by 127
Human polymorphonuclear leukocytes adhere to complement factor H through an interaction that involves alphaMbeta2 (CD11b/CD18).
DiScipio, R. G., Daffern, P. J., Schraufstätter, I. U., & Sriramarao, P. (1998) · PubMed · Cited by 126
Small interfering RNA-mediated suppression of Ccl2 in Müller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration
Rutar, M., Natoli, R., & Provis, J. M. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-221 · Cited by 125
Changes in Retinal Sensitivity in Geographic Atrophy Progression as Measured by Microperimetry
Meleth, A. D., Mettu, P., Agrón, E., Chew, E. Y., Sadda, S. R., Ferris, F. L., & Wong, W. T. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6075 · Cited by 123
Inhibition of TNF-α reduces laser-induced choroidal neovascularization
Shi, X., Semkova, I., Muether, P. S., Dell, S., Kociok, N., & Joussen, A. M. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2006.07.007 · Cited by 123
Abdominal Obesity and Age-related Macular Degeneration
Adams, M. K. M., Simpson, J. A., Aung, K. Z., Makeyeva, G. A., Giles, G. G., English, D. R., Hopper, J. L., Guymer, R. H., Baird, P. N., & Robman, L. D. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwr005 · Cited by 123
Prospective Assessment of Genetic Effects on Progression to Different Stages of Age-Related Macular Degeneration Using Multistate Markov Models
Yu, Y., Reynolds, R. C., ROSNER, B. A., Daly, M. J., & Seddon, J. M. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8657 · Cited by 122
Identification of Novel Substrates for the Serine Protease HTRA1 in the Human RPE Secretome
An, E., Sen, S., Park, S. K., Gordish‐Dressman, H., & Hathout, Y. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4853 · Cited by 121
Organization and Differential Expression of the Human Monocyte Chemoattractant Protein 1 Receptor Gene
Wong, L.-M., Myers, S. J., Tsou, C.-L., Gosling, J., Arai, H., & Charo, I. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.1038 · Cited by 121
The VEGF-induced transcriptional response comprises gene clusters at the crossroad of angiogenesis and inflammation
Schweighofer, B., Testori, J., Sturtzel, C., Sattler, S., Mayer, H., Wagner, O. F., Bilban, M., & Hofer, E. (2009) · Thrombosis and Haemostasis · doi:10.1160/th08-12-0830 · Cited by 120
Infiltration of Proinflammatory M1 Macrophages into the Outer Retina Precedes Damage in a Mouse Model of Age-Related Macular Degeneration
Cruz‐Guilloty, F., Saeed, A. M., Echegaray, J. J., Duffort, S., Ballmick, A., Tan, Y., Betancourt, M., Viteri, E. J., Ramkhellawan, G. C., Ewald, E. J., et al. (2013) · International Journal of Inflammation · doi:10.1155/2013/503725 · Cited by 120
Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B
Montes, T., Tortajada, A., Morgan, B. P., de Córdoba, S. R., & Harris, C. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812584106 · Cited by 117
Cholesterol and age-related macular degeneration: is there a link?
van Leeuwen, R., Klaver, C. C. W., Vingerling, J. R., Albert Hofman, D., van Duijn, C. M., Stricker, B. H. C., & de Jong, P. T. V. M. (2004) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2003.09.015 · Cited by 117
Human Polymorphonuclear Leukocytes Adhere to Complement Factor H Through an Interaction That Involves αMβ2 (CD11b/CD18)
DiScipio, R. G., Daffern, P. J., Schraufstätter, I. U., & Sriramarao, P. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.8.4057 · Cited by 117
Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man
Cideciyan, A. V., Haeseleer, F., Fariss, R. N., Alemán, T. S., Jang, G.-F., Verlinde, C. L. M. J., Marmor, M. F., Jacobson, S. G., & Palczewski, K. (2000) · Visual Neuroscience · doi:10.1017/s0952523800175029 · Cited by 116
Localization of the complement-component-C3b-binding site and the cofactor activity for factor I in the 38kDa tryptic fragment of factor H
Alsenz, J., Lambris, J. D., Schulz, T. F., & Dierich, M. P. (1984) · Biochemical Journal · doi:10.1042/bj2240389 · Cited by 116
CD14 signalling in lipid rafts: new ligands and co-receptors
Schmitz, G., & Orsó, E. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200210000-00007 · Cited by 115
AN ULTRASTRUCTURAL STUDY OF THE ROLE OF LEUCOCYTES AND FIBROBLASTS IN THE BREAKDOWN OF BRUCH'S MEMBRANE
MPhil, P. P., BSppSc, M. K., & Sarks, S. H. (1984) · Australian Journal of Opthalmology · doi:10.1111/j.1442-9071.1984.tb01120.x · Cited by 115
Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration
Suzuki, M., Tsujikawa, M., Itabe, H., Du, Z.-J., Xie, P., Matsumura, N., Fu, X., Zhang, R., Sonoda, K., Egashira, K., et al. (2012) · Journal of Cell Science · doi:10.1242/jcs.097683 · Cited by 115
Dysregulation in Retinal Para-Inflammation and Age-Related Retinal Degeneration in CCL2 or CCR2 Deficient Mice
Chen, M., Forrester, J. V., & Xu, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022818 · Cited by 114
Reduced levels of human apoE4 protein in an animal model of cognitive impairment
Sullivan, P. M., Han, B., Liu, F., Mace, B. E., Ervin, J. F., Wu, S., Koger, D., Paul, S., & Bales, K. R. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.05.011 · Cited by 113
Factor H and Factor H-Related Protein 1 Bind to Human Neutrophils via Complement Receptor 3, Mediate Attachment to Candida albicans , and Enhance Neutrophil Antimicrobial Activity
Losse, J., Zipfel, P. F., & Józsi, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901702 · Cited by 113
Myeloid Cells Expressing VEGF and Arginase-1 Following Uptake of Damaged Retinal Pigment Epithelium Suggests Potential Mechanism That Drives the Onset of Choroidal Angiogenesis in Mice
Liu, J., Copland, D. A., Horie, S., Wei-kang, W., Chen, M., Xu, Y., Morgan, B. P., Mack, M., Xu, H., Nicholson, L. B., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072935 · Cited by 111
Regulated expression of apolipoprotein E by human retinal pigment epithelial cells
Ishida, B. Y., Bailey, K. R., Duncan, K. G., Chalkley, R. J., Burlingame, A. L., Kane, J. P., & Schwartz, D. M. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300306-jlr200 · Cited by 111
HISTORY OF SUNLIGHT EXPOSURE IS A RISK FACTOR FOR AGE-RELATED MACULAR DEGENERATION
Schick, T., Ersoy, L., Lechanteur, Y. T. E., Saksens, N. T. M., Hoyng, C. B., den Hollander, A. I., Kirchhof, B., & Fauser, S. (2015) · Retina · doi:10.1097/iae.0000000000000756 · Cited by 111
Subducted and melanotic cells in advanced age-related macular degeneration are derived from retinal pigment epithelium
Zanzottera, E. C., Messinger, J. D., Ach, T., Smith, R. T., & Curcio, C. A. (2015) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.15-16432 · Cited by 110
Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation
Ma, W., Cojocaru, R. I., Gotoh, N., Gieser, L. M., Villasmil, R., Cogliati, T., Swaroop, A., & Wong, W. T. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.022 · Cited by 108
The dynamics of leukocyte infiltration in experimental autoimmune uveoretinitis
Kerr, E. C., Copland, D. A., Dick, A. D., & Nicholson, L. B. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.07.001 · Cited by 108
Complement gene expression and regulation in mouse retina and retinal pigment epithelium/choroid.
Luo, C., Chen, M., & Xu, H. (2011) · PubMed Central · Cited by 107
Distribution and Quantification of Choroidal Macrophages in Human Eyes With Age-Related Macular Degeneration
McLeod, D. S., Bhutto, I. A., Edwards, M. M., Silver, R. E., Seddon, J. M., & Lutty, G. A. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20049 · Cited by 107
Inflammation, Complement Factor H, and Age-Related Macular Degeneration
Klein, R., Knudtson, M. D., Klein, B. E. K., Wong, T. Y., Cotch, M. F., Liu, K., Cheng, C. Y., Burke, G. L., Saad, M. F., Jacobs, D. R., et al. (2008) · Ophthalmology · doi:10.1016/j.ophtha.2008.03.021 · Cited by 106
Interleukin-1 as a mediator of fatigue in disease: a narrative review
Roerink, M. E., van der Schaaf, M. E., Dinarello, C. A., Knoop, H., & van der Meer, J. W. M. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0796-7 · Cited by 105
DEFECTIVE GLUCOSE HOMEOSTASIS DURING INFECTION
McGuinness, O. P. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132159 · Cited by 104
Abundance of infiltrating CD163+ cells in the retina of postmortem eyes with dry and neovascular age-related macular degeneration
Lad, E. M., Cousins, S. W., Arnam, J. S. V., & Proia, A. D. (2015) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-015-3094-z · Cited by 102
APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration
Levy, O., Lavalette, S., Hu, S. J., Housset, M., Raoul, W., Eandi, C. M., Sahel, J., Sullivan, P. M., Guillonneau, X., & Sennlaub, F. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2468-15.2015 · Cited by 101
Self-citation
Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator
Micklisch, S., Lin, Y., Jacob, S., Karlstetter, M., Dannhausen, K., Dasari, P., von der Heide, M., Dahse, H., Schmölz, L., Graßmann, F., et al. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0776-3 · Cited by 101
From development to dysfunction: Microglia and the complement cascade in CNS homeostasis
Zabel, M. K., & Kirsch, W. M. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.02.001 · Cited by 100
Immunohistochemical characterization of surgically removed subfoveal fibrovascular membranes
Seregard, S., Algvere, P. V., & Berglin, L. (1994) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/bf00175983 · Cited by 99
Adaptive Optics Imaging of Geographic Atrophy
Gocho, K., Sarda, V., Falah, S., Sahel, J., Sennlaub, F., Benchaboune, M., Ullern, M., & Pâques, M. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10672 · Cited by 97
Self-citation
Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes.
Sinnis, P., Willnow, T. E., Briones, M. R. S., Herz, J., & Nussenzweig, V. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.3.945 · Cited by 97
Prenatal cytomegalovirus infection: epidemiology, pathology and pathogenesis.
Dm, B. (1981) · PubMed · Cited by 97
Crosstalk between reverse cholesterol transport and innate immunity
Azzam, K. M., & Fessler, M. B. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.02.001 · Cited by 96
Increased micro-RNA 29b in the aged brain correlates with the reduction of insulin-like growth factor-1 and fractalkine ligand
Fenn, A. M., Smith, K. M., Lovett‐Racke, A. E., Guerau‐de‐Arellano, M., Whitacre, C. C., & Godbout, J. P. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.06.007 · Cited by 96
Subretinal mononuclear phagocytes induce cone segment loss via IL-1β
Eandi, C. M., Charles‐Messance, H., Augustin, S., Dominguez, E., Lavalette, S., Forster, V., Hu, S. J., Siqueiros‐Márquez, L., Craft, C. M., Sahel, J., et al. (2016) · eLife · doi:10.7554/elife.16490 · Cited by 96
Self-citation
Upregulation of P2RX7 inCx3cr1-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1β Secretion and Photoreceptor Neurodegeneration
Hu, S. J., Calippe, B., Lavalette, S., Roubeix, C., Montassar, F., Housset, M., Levy, O., Delarasse, C., Pâques, M., Sahel, J., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3955-14.2015 · Cited by 95
Self-citation
Proteomics of Vitreous Humor of Patients with Exudative Age-Related Macular Degeneration
Koss, M., Hoffmann, J., Nguyen, N., Pfister, M., Mischak, H., Mullen, W., Husi, H., Ręjdak, R., Koch, F., Jankowski, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096895 · Cited by 95
Estimation of Systemic Complement C3 Activity in Age-Related Macular Degeneration
Sivaprasad, S. (2007) · Archives of Ophthalmology · doi:10.1001/archopht.125.4.515 · Cited by 95
Increased choroidal mast cells and their degranulation in age-related macular degeneration
Bhutto, I. A., McLeod, D. S., JING, T. Y., Sunness, J. S., Seddon, J. M., & Lutty, G. A. (2016) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2015-308290 · Cited by 95
Effects of cholesterol and apolipoprotein E on retinal abnormalities in ApoE-deficient mice.
Ong, J. M., Zorapapel, N. C., Rich, K. A., Wagstaff, R. E., Lambert, R. W., Rosenberg, S., Moghaddas, F., Pirouzmanesh, A., Aoki, A. M., & Kenney, M. C. (2001) · PubMed · Cited by 92
Prosperity's Plague
Taubes, G. (2009) · Science · doi:10.1126/science.325_256 · Cited by 91
High IL-13 production by human neonatal T cells: neonate immune system regulator?
Ribeiro-do-Couto, L. M., Boeije, L. C. M., Kroon, J., Hooibrink, B., Breur-Vriesendorp, B. S., Aarden, L. A., & Boog, C. J. P. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200111)31:11 · Cited by 91
Interleukin-6 in Retinal Ischemia Reperfusion Injury in Rats
Sanchez, R. N., Chan, C. K.-C., Garg, S., Kwong, J. M. K., Wong, M. J., Sadun, A. A., & Lam, T. T. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0040 · Cited by 90
Relationship between Systemic Cytokines and Complement Factor H Y402H Polymorphism in Patients With Dry Age-Related Macular Degeneration
Cao, S., Ko, A., Partanen, M., Pakzad-Vaezi, K. L., Merkur, A. B., Albiani, D. A., Kirker, A. W., Wang, A., Cui, J. Z., Forooghian, F., et al. (2013) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2013.08.003 · Cited by 89
Photoreceptor Impairment and Restoration on Optical Coherence Tomographic Image
Mitamura, Y., Mitamura-Aizawa, S., Katome, T., Naito, T., Hagiwara, A., Kumagai, K., & Yamamoto, S. (2013) · Journal of Ophthalmology · doi:10.1155/2013/518170 · Cited by 89
CD47 Augments Fas/CD95-mediated Apoptosis
Manna, P. P., Dimitry, J. M., Oldenborg, P., & Frazier, W. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500922200 · Cited by 85
Complement factor H and the hemolytic uremic syndrome
Atkinson, J. P., & Goodship, T. H. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070664 · Cited by 85
CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans
Martínez‐Torres, A. C., Quiney, C., Attout, T., Boullet, H., Herbi, L., Vela, L., Barbier, S., Château, D., Chapiro, É., Nguyen‐Khac, F., et al. (2015) · PLoS Medicine · doi:10.1371/journal.pmed.1001796 · Cited by 84
Age-related macular degeneration: The importance of family history as a risk factor
Shahid, H., Khan, J. C., Cipriani, V., Sepp, T., Matharu, B. K., Bunce, C., Harding, S. P., Clayton, D. G., Moore, A. T., Yates, J. R. W., et al. (2012) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2011-300193 · Cited by 84
Inflammatory cytokines in aqueous humor of patients with choroidal neovascularization.
Miao, H., Tao, Y. K., & Li, X. (2012) · PubMed Central · Cited by 83
Peripheral blood mononuclear cells from neovascular age-related macular degeneration patients produce higher levels of chemokines CCL2 (MCP-1) and CXCL8 (IL-8)
Lechner, J., Chen, M., Hogg, R. E., Tóth, L., Silvestri, G., Chakravarthy, U., & Xu, H. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0820-y · Cited by 83
Fractalkine receptor regulates microglial neurotoxicity in an experimental mouse glaucoma model
Wang, K., Peng, B., & Lin, B. (2014) · Glia · doi:10.1002/glia.22715 · Cited by 82
Accumulation of murine subretinal macrophages: effects of age, pigmentation and CX3CR1
Chinnery, H. R., McLenachan, S., Humphries, T. G., Kezic, J. M., Chen, X., Ruitenberg, M. J., & McMenamin, P. G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.010 · Cited by 82
Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina
Cardona, S. M., Mendiola, A. S., Yang, Y.-C., Adkins, S. L., Torres, V., & Cardona, A. E. (2015) · ASN NEURO · doi:10.1177/1759091415608204 · Cited by 82
Knockout of ccr2 alleviates photoreceptor cell death in a model of retinitis pigmentosa
Guo, C., Otani, A., Oishi, A., Kojima, H., Makiyama, Y., Nakagawa, S., & Yoshimura, N. (2012) · Experimental Eye Research · doi:10.1016/j.exer.2012.08.013 · Cited by 81
Myeloid Differentiation Primary Response Protein 88 Couples Reverse Cholesterol Transport to Inflammation
Smoak, K. A., Aloor, J. J., Madenspacher, J. H., Merrick, B. A., Collins, J. B., Zhu, X., Cavigiolio, G., Oda, M. N., Parks, J. S., & Fessler, M. B. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.006 · Cited by 81
Interleukin-6 as a Photoreceptor Neuroprotectant in an Experimental Model of Retinal Detachment
Chong, D. Y., Boehlke, C. S., Zheng, Q.-D., Zhang, L., Han, Y., & Zacks, D. N. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1641 · Cited by 79
CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production
Arnold, L., Perrin, H., de Chanville, C. B., Saclier, M., Hermand, P., Poupel, L., Guyon, E., Licata, F., Carpentier, W., Vilar, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms9972 · Cited by 78
Loss of Otx2 in the Adult Retina Disrupts Retinal Pigment Epithelium Function, Causing Photoreceptor Degeneration
Housset, M., Samuel, A., Ettaiche, M., Bemelmans, A., Béby, F., Billon, N., & Lamonerie, T. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1099-13.2013 · Cited by 76
The Intraocular Cytokine Profile and Therapeutic Response in Persistent Neovascular Age-Related Macular Degeneration
Rezar‐Dreindl, S., Sacu, S., Eibenberger, K., Pollreisz, A., Buehl, W., Georgopoulos, M., Krall, C., Weigert, G., & Schmidt-Erfurth, U. M. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19772 · Cited by 76
In vivo upregulation of CD95 and CD95L causes synergistic inhibition of angiogenesis by TSP1 peptide and metronomic doxorubicin treatment
Quesada, A. J., Nelius, T., Yap, R. X. J., Zaichuk, T. A., Alfranca, A., Filleur, S., Volpert, O. V., & Redondo, J. M. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401615 · Cited by 75
Relative Contribution of VEGF and TNF-α in the Cynomolgus Laser-Induced CNV Model: Comparing the Efficacy of Bevacizumab, Adalimumab, and ESBA105
Lichtlen, P., Lam, T. T., Nork, T. M., Streit, T., & Urech, D. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4890 · Cited by 75
Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency
Friedrich, U., Myers, C. A., Fritsche, L. G., Milenkovic, A., Wolf, A., Corbo, J. C., & Weber, B. H. F. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr020 · Cited by 74
Changes in Abdominal Obesity and Age-Related Macular Degeneration
Peeters, A. (2008) · Archives of Ophthalmology · doi:10.1001/archopht.126.11.1554 · Cited by 72
Immune cells in the human choroid
Ezzat, M.-K., Hann, C. R., Vuk‐Pavlović, S., & Pulido, J. S. (2008) · British Journal of Ophthalmology · doi:10.1136/bjo.2007.129742 · Cited by 71
Epigenetic signature and enhancer activity of the human APOE gene
Yu, C., Cudaback, E., Foraker, J. E., Thomson, Z., Leong, L., Lutz, F., Gill, J. A., Saxton, A. D., Kraemer, B. C., Navas, P. A., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt354 · Cited by 71
Inhibition of Laser-Induced Choroidal Neovascularization by Atorvastatin by Downregulation of Monocyte Chemotactic Protein-1 Synthesis in Mice
Yamada, K., Sakurai, E., Itaya, M., Yamasaki, S., & Ogura, Y. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-1085 · Cited by 70
Production and accumulation of thrombospondin-1 in human retinal pigment epithelial cells.
Miyajima–Uchida, H., Hayashi, H., Beppu, R., Kuroki, M., Fukami, M., Arakawa, F., Tomita, Y., Kuroki, M., & Oshima, K. (2000) · PubMed · Cited by 66
Para‐inflammation‐mediated retinal recruitment of bone marrow‐derived myeloid cells following whole‐body irradiation is CCL2 dependent
Chen, M., Zhao, J., Luo, C., Pandi, S. P. S., Peñalva, R. G., Fitzgerald, D. C., & Xu, H. (2012) · Glia · doi:10.1002/glia.22315 · Cited by 66
Leukotrienes and macrophage activation: Augmented cytotoxic activity and enhanced interleukin 1, tumor necrosis factor and hydrogen peroxide production
Gagnon, L., Filion, L. G., Dubois, C. M., & Rola‐Pleszczynski, M. (1989) · Inflammation Research · doi:10.1007/bf02126587 · Cited by 65
Understanding macrophage diversity at the ontogenic and transcriptomic levels
Gautier, E. L., & Yvan‐Charvet, L. (2014) · Immunological Reviews · doi:10.1111/imr.12231 · Cited by 65
The clearance of apoptotic cells by complement
Flierman, R., & Daha, M. R. (2006) · Immunobiology · doi:10.1016/j.imbio.2006.11.005 · Cited by 64
Elevated Plasma Levels of C3a Complement Compound in the Exudative Form of Age-Related Macular Degeneration
Machalińska, A., Dziedziejko, V., Mozolewska‐Piotrowska, K., Karczewicz, D., Wiszniewska, B., & Machaliński, B. (2009) · Ophthalmic Research · doi:10.1159/000219686 · Cited by 62
Lack of thrombospondin 1 and exacerbation of choroidal neovascularization
Wang, S., Sorenson, C. M., & Sheibani, N. (2012) · Archives of Ophthalmology · doi:10.1001/archopthalmol.2011.1892 · Cited by 61
Persistent Inflammation Subverts Thrombospondin-1–Induced Regulation of Retinal Angiogenesis and Is Driven by CCR2 Ligation
Chen, M., Copland, D. A., Zhao, J., Liu, J., Forrester, J. V., Dick, A. D., & Xu, H. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.09.020 · Cited by 60
Temporal and spatial delineation of mouse Otx2 functions by conditional self‐knockout
Fossat, N., Chatelain, G., Brun, G., & Lamonerie, T. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400751 · Cited by 60
Human HtrA1 in the archived eyes with age-related macular degeneration.
Chan, C., Shen, D., Zhou, M., Ross, R. J., Ding, X., Zhang, K., Green, W. R., & Tuo, J. (2007) · Europe PMC (PubMed Central) · Cited by 59
Mechanisms of regulation for interleukin-1β in neurodegenerative disease
Simi, A., Lerouet, D., Pinteaux, E., & Brough, D. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.02.011 · Cited by 58
Past physical activity and age-related macular degeneration: the Melbourne Collaborative Cohort Study
McGuinness, M. B., Karahalios, A., Simpson, J. A., Guymer, R. H., Robman, L. D., Hodge, A. M., Cerin, E., Giles, G. G., & Finger, R. P. (2016) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2015-307663 · Cited by 58
CD47: a new player in phagocytosis and xenograft rejection
Navarro–Álvarez, N., & Yang, Y. (2011) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.83 · Cited by 57
Fractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy
Mendiola, A. S., Garza, R., Cardona, S. M., Mythen, S. A., Lira, S. A., Akassoglou, K., & Cardona, A. E. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00303 · Cited by 57
The Effects of Age and Cx 3 cr1 Deficiency on Retinal Microglia in the Ins2 Akita Diabetic Mouse
Kezic, J. M., Chen, X., Rakoczy, E. P., & McMenamin, P. G. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10876 · Cited by 53
Intravitreal Anakinra Inhibits Choroidal Neovascular Membrane Growth in a Rat Model
Olson, J. L., Courtney, R. J., Rouhani, B., Mandava, N., & Dinarello, C. A. (2009) · Ocular Immunology and Inflammation · doi:10.1080/09273940802710705 · Cited by 53
CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes
Beli, E., Dominguez, J. M., Hu, P., Thinschmidt, J. S., Caballero, S., Calzi, S. L., Luo, D., Shanmugam, S., Salazar, T. E., Duan, Y., et al. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1433-0 · Cited by 52
Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration
Luhmann, U. F. O., Carvalho, L. S., Robbie, S. J., Cowing, J. A., Durán, Y., Munro, P., Bainbridge, J. W., & Ali, R. R. (2012) · Experimental Eye Research · doi:10.1016/j.exer.2012.11.015 · Cited by 51
Aqueous Interleukin-6 Levels Are Superior to Vascular Endothelial Growth Factor in Predicting Therapeutic Response to Bevacizumab in Age-Related Macular Degeneration
Chalam, K. V., Grover, S., Sambhav, K., Balaiya, S., & Murthy, R. K. (2014) · Journal of Ophthalmology · doi:10.1155/2014/502174 · Cited by 51
Genetic Variants and Systemic Complement Activation Levels Are Associated With Serum Lipoprotein Levels in Age-Related Macular Degeneration
Paun, C. C., Ersoy, L., Schick, T., Groenewoud, J. M. M., Lechanteur, Y. T. E., Fauser, S., Hoyng, C. B., de Jong, E. K., & den Hollander, A. I. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-17035 · Cited by 51
Monocyte chemoattractant protein‐1 in the aqueous humour of patients with age‐related macular degeneration
Kramer, M., Hasanreisoğlu, M., Feldman, A., Axer‐Siegel, R., Sonis, P., Maharshak, I., Monselise, Y., Gurevich, M., & Weinberger, D. (2011) · Clinical and Experimental Ophthalmology · doi:10.1111/j.1442-9071.2011.02747.x · Cited by 50
Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX 2 expression via TNF ‐α
Mathis, T., Housset, M., Eandi, C. M., Béguier, F., Touhami, S., Reichman, S., Augustin, S., Gondouin, P., Sahel, J., Kodjikian, L., et al. (2016) · Aging Cell · doi:10.1111/acel.12540 · Cited by 50
Self-citation
Deletion of the p85α Regulatory Subunit of Phosphoinositide 3-Kinase in Cone Photoreceptor Cells Results in Cone Photoreceptor Degeneration
Ivanovic, I., Anderson, R. E., Le, Y. Z., Fliesler, S. J., Sherry, D. M., & Rajala, R. V. S. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-7139 · Cited by 49
The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors
Luhmann, U. F. O., Carvalho, L. S., Holthaus, S.-M. K., Cowing, J. A., Greenaway, S., Chu, C. J., Herrmann, P., Smith, A. J., Munro, P., Potter, P. K., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu424 · Cited by 49
Lifestyle Exposures and Eye Diseases in Adults
Klein, R., & Klein, R. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2007.08.016 · Cited by 48
Thrombospondin-1-mediated regulation of microglia activation after retinal injury
Ng, T. F., Turpie, B., & Masli, S. (2009) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.08-2877 · Cited by 48
Lipopolysaccharide Increases the Incidence of Collagen‐Induced Arthritis in Mice Through Induction of Protease HTRA‐1 Expression
Hou, Y., Lin, H., Zhu, L., Liu, Z., Hu, F., Shi, J., Yang, T., Shi, X., Zhu, M., Godley, B. F., et al. (2013) · Arthritis & Rheumatism · doi:10.1002/art.38124 · Cited by 47
Insulin Receptor Signaling in Cones
Rajala, A., Dighe, R., Agbaga, M., Anderson, R. E., & Rajala, R. V. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.469064 · Cited by 47
Age-related Macular Degeneration and Modification of Systemic Complement Factor H Production Through Liver Transplantation
Khandhadia, S., Hakobyan, S., Heng, L. Z., Gibson, J., Adams, D. H., Alexander, G. J., Gibson, J. M., Martin, K. R., Menon, G., Nash, K., et al. (2013) · Ophthalmology · doi:10.1016/j.ophtha.2013.01.004 · Cited by 47 · cited 1×
“…not harmful, effect in AMD (Dhillon et al., 2010), (iv) the recipient, but not the liver Cfh genotype confers AMD-risk in liver transplant patients (Khandhadia et al., 2013), suggesting that plasma CFH is not involved in AMD pathogenesis and points to the possible importance of MP-derived CFH in…”
Background
Current knowledge on reticular pseudodrusen in age-related macular degeneration
Alten, F., & Eter, N. (2014) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2014-305339 · Cited by 47
Chromosome 10q26 locus and age-related macular degeneration: A progress update
Wang, G. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.11.009 · Cited by 46
CX3CL1 (Fractalkine) Protein Expression in Normal and Degenerating Mouse Retina: In Vivo Studies
Zieger, M. V., Ahnelt, P. K., & Uhrín, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106562 · Cited by 46
Transcriptome Analysis on Monocytes from Patients with Neovascular Age-Related Macular Degeneration
Grunin, M. A., Hagbi-Levi, S., Rinsky, B., Smith, Y., & Chowers, I. (2016) · Scientific Reports · doi:10.1038/srep29046 · Cited by 46
Vascular Associations and Dynamic Process Motility in Perivascular Myeloid Cells of the Mouse Choroid: Implications for Function and Senescent Change
Kumar, A., Zhao, L., Fariss, R. N., McMenamin, P. G., & Wong, W. T. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-13522 · Cited by 45
ROLE OF STATINS IN THE DEVELOPMENT AND PROGRESSION OF AGE-RELATED MACULAR DEGENERATION
VanderBeek, B. L., Zacks, D. N., Talwar, N., Nan, B., & Stein, J. D. (2013) · Retina · doi:10.1097/iae.0b013e318276e0cf · Cited by 45
Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue light
Hu, Z., Zhang, Y., Wang, J., Mao, P., Lv, X., Yuan, S., Huang, Z., Ding, Y., Xie, P., & Liu, Q. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.363 · Cited by 45
Human complement Factor H modulates C1q-mediated phagocytosis of apoptotic cells
Kang, Y.-H., Urban, B. C., Sim, R. B., & Kishore, U. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.10.008 · Cited by 44
Identification of Urinary Biomarkers for Age-Related Macular Degeneration
Guymer, R. H., Tao, L. W., Goh, J., Liew, D., Ischenko, O. P., Robman, L. D., Aung, K.-Z., Cipriani, T., Cain, M. S., Richardson, A. J., et al. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-7120 · Cited by 43
CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization
Horie, S., Robbie, S. J., Liu, J., Wei-kang, W., Ali, R. R., Bainbridge, J. W., Nicholson, L. B., Mochizuki, M., Dick, A. D., & Copland, D. A. (2013) · Scientific Reports · doi:10.1038/srep03072 · Cited by 41
Age-Dependent Changes in FasL (CD95L) Modulate Macrophage Function in a Model of Age-Related Macular Degeneration
Zhao, H., Roychoudhury, J., Doggett, T. A., Apte, R. S., & Ferguson, T. A. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12122 · Cited by 40
Expression and regulation of complement factors H and I in rat and human cells: some critical notes
Schlaf, G. (2001) · Molecular Immunology · doi:10.1016/s0161-5890(01)00045-1 · Cited by 38
Transmission Electron Microscopic Study of a Subretinal Choroidal Neovascular Membrane due to Age-Related Macular Degeneration
Gehrs, K. M. (1992) · Archives of Ophthalmology · doi:10.1001/archopht.1992.01080180105036 · Cited by 36
An Amyloid-Like C-Terminal Domain of Thrombospondin-1 Displays CD47 Agonist Activity Requiring Both VVM Motifs
McDonald, J. F., Dimitry, J. M., & Frazier, W. A. (2003) · Biochemistry · doi:10.1021/bi0341408 · Cited by 35
Association of Hyperreflective Foci Present in Early Forms of Age-Related Macular Degeneration With Known Age-Related Macular Degeneration Risk Polymorphisms
Altay, L., Scholz, P., Schick, T., Felsch, M., Hoyng, C. B., den Hollander, A. I., Langmann, T., & Fauser, S. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-18855 · Cited by 35
Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages
Camelo, S., Raoul, W., Lavalette, S., Calippe, B., Cristofaro, B., Levy, O., Houssier, M., Sulpice, E., Jonet, L., Klein, C., et al. (2012) · Angiogenesis · doi:10.1007/s10456-012-9290-0 · Cited by 34
Self-citation
Intraocular and systemic inflammation‐related cytokines during one year of ranibizumab treatment for neovascular age‐related macular degeneration
Fauser, S., Viebahn, U., & Muether, P. S. (2015) · Acta Ophthalmologica · doi:10.1111/aos.12770 · Cited by 33
Environmental conditioning in the control of macrophage thrombospondin-1 production
Fordham, J. B., Hua, J., Morwood, S. R., Schewitz‐Bowers, L. P., Copland, D. A., Dick, A. D., & Nicholson, L. B. (2012) · Scientific Reports · doi:10.1038/srep00512 · Cited by 33
Paraquat-Induced Retinal Degeneration Is Exaggerated in CX3CR1-Deficient Mice and Is Associated with Increased Retinal Inflammation
Chen, M., Luo, C., Peñalva, R. G., & Xu, H. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10888 · Cited by 33
Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging
Robbie, S. J., Georgiadis, A., Barker, S. E., Durán, Y., Smith, A. J., Ali, R. R., Luhmann, U. F. O., & Bainbridge, J. W. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.12.019 · Cited by 32
CCR2/CCL2-mediated inflammation protects photoreceptor cells from amyloid-β-induced apoptosis
Bruban, J., Maoui, A., Chalour, N., An, N., Jonet, L., Feumi, C., Tréton, J., Sennlaub, F., Béhar‐Cohen, F., Mascarelli, F., et al. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.004 · Cited by 31
Self-citation
Complement Factor H Autoantibodies and Age-Related Macular Degeneration
Dhillon, B., Wright, A. F., Tufail, A., Pappworth, I. Y., Hayward, C., Moore, I., Strain, L., Kavanagh, D., Barlow, P. N., Herbert, A. P., et al. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-5124 · Cited by 31
Physical Activity and the 15-Year Incidence of Age-Related Macular Degeneration
Gopinath, B., Liew, G., Burlutsky, G., & Mitchell, P. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-15575 · Cited by 30
Keratan sulfate expression in microglia is diminished in the spinal cord in experimental autoimmune neuritis
Matsui, H., Ohgomori, T., Natori, T., Miyamoto, K., Kusunoki, S., Sakamoto, K., Ishiguro, N., Imagama, S., & Kadomatsu, K. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.479 · Cited by 30
Drusen Regression is Associated With Local Changes in Fundus Autofluorescence in Intermediate Age-Related Macular Degeneration
Toy, B. C., Krishnadev, N., Indaram, M., Cunningham, D., Cukras, C. A., Chew, E. Y., & Wong, W. T. (2013) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2013.04.031 · Cited by 29
Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration
Kohno, H., Koso, H., Okano, K., Sundermeier, T. R., Saitô, S., Watanabe, S., Tsuneoka, H., & Sakai, T. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0408-3 · Cited by 29
Dynamic soft drusen remodelling in age-related macular degeneration
Smith, R. T., Sohrab, M. A., Pumariega, N. M., Chen, Y., Chen, J., Lee, N., & Laine, A. F. (2010) · British Journal of Ophthalmology · doi:10.1136/bjo.2009.166843 · Cited by 28
In vitro-staining specificity of the antibody 5-D-4 for microglia but not for monocytes and macrophages indicates that microglia are a unique subgroup of the myelomonocytic lineage
Wilms, H., Wollmer, M. A., & Sievers, J. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00066-1 · Cited by 26
Prospective Study of Common Variants inCX3CR1and Risk of Macular Degeneration
Schaumberg, D. A., Rose, L. M., DeAngelis, M. M., Semba, R. D., Hageman, G. S., & Chasman, D. I. (2013) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2013.5506 · Cited by 26
Cells resembling intraventricular macrophages are present in the subretinal space of human foetal eyes
McMenamin, P. G., & Loeffler, K. U. (1990) · The Anatomical Record · doi:10.1002/ar.1092270213 · Cited by 26
Dynamic Drusen Remodelling in Participants of the Nutritional AMD Treatment-2 (NAT-2) Randomized Trial
Querques, G., Merle, B. M. J., Pumariega, N. M., Benlian, P., Delcourt, C., Zourdani, A., Leisy, H. B., Lee, M. D., Smith, R. T., & Souied, E. H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149219 · Cited by 26
Phosphoinositide 3-kinase signaling in retinal rod photoreceptors
Ivanovic, I., Allen, D. T., Dighe, R., Le, Y. Z., Anderson, R. E., & Rajala, R. V. S. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-7138 · Cited by 25
Thrombospondin-1 and Pathogenesis of Age-Related Macular Degeneration
Housset, M., & Sennlaub, F. (2015) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2015.0023 · Cited by 21
Self-citation
Complement Factor H Y402H polymorphism is associated with an increased risk of mortality after intracerebral hemorrhage
Appelboom, G., Piazza, M. A., Hwang, B. Y., Bruce, S. S., Smith, S., Bratt, A., Bagiella, E., Badjatia, N., Mayer, S. A., & Connolly, E. S. (2011) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2011.04.001 · Cited by 20
Association of Choroidal Interleukin-17-Producing T Lymphocytes and Macrophages with Geographic Atrophy
Camelo, S., Lavelette, S., Guillonneau, X., Raoul, W., & Sennlaub, F. (2016) · Ophthalmologica · doi:10.1159/000446587 · Cited by 20
Self-citation
Associations Between the T280M and V249I SNPs in CX3CR1 and the Risk of Age-Related Macular Degeneration
Zhang, R., Wang, L., Wang, Y.-F., Wu, C., Lei, C.-L., Wang, M., & Ma, L. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-16830 · Cited by 18
Cigarette smoking strongly modifies the association of complement factor H variant and the risk of lung cancer
Zhang, Z., Yu, D., Yuan, J., Guo, Y., Wang, H., & Zhang, X. (2011) · Cancer Epidemiology · doi:10.1016/j.canep.2011.11.004 · Cited by 15
RETINAL ANGIOMATOUS PROLIFERATION IN AGE-RELATEDd MSCULAR DEGENERATION
Ghazi, N. G. (2002) · Retina · doi:10.1097/00006982-200208000-00023 · Cited by 15
Eicosanoids, inflammation, and anti-inflammatory drugs.
Robinson, D. R. (1990) · PubMed · Cited by 14
Association of Sequence Variation in the CX3CR1 Gene with Geographic Atrophy Age-related Macular Degeneration in a Greek Population
Anastasopoulos, E., Kakoulidou, A., Coleman, A. L., Sinsheimer, J. S., Wilson, M. R., Yu, F., Salonikiou, A., Koskosas, A., Pappas, T., Founti, P., et al. (2012) · Current Eye Research · doi:10.3109/02713683.2012.705413 · Cited by 13
Comment on “Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration” by Luhmann et al. (Exp. Eye Res. 2013; 107: 80.doi: 10.1016)
Combadière, C., Raoul, W., Guillonneau, X., & Sennlaub, F. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.02.002 · Cited by 12
Self-citation
Obesity and HLA in multiple sclerosis
Marrie, R. A., & Beck, C. A. (2014) · Neurology · doi:10.1212/wnl.0000000000000195 · Cited by 9
Macrophages or retinal pigment epithelium expressing macrophage markers in age-related macular degeneration? Comment on Lad et al. 2015
Curcio, C. A., & Ach, T. (2016) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-016-3300-7 · Cited by 7
HtrA1 regulates the subretinal infiltration of microglia cells in response to bacterial lipopolysaccharides (LPS) and aging in mice
Liao, S.-M., Crowley, M. A., Louie, S., Delgado, O., Buchanan, N. M., Stefanidakis, M., & JAFFEE, B. D. (2013) · Investigative Ophthalmology & Visual Science · Cited by 4

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5 of the 399 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

Hegner, 1916, Retinitis exsudativa bei Lymphogranulomatosis, Klin. Monatsbl Augenheil, 57, 27
Mimoun, 1990, [Macular drusen], J. francais d'ophtalmologie, 13, 511
Sha-Mei, 2016, AMD-associated SNPs in the ARMS2/HTRA1 locus influence local gene expression in multiple human tissues, Invest. Ophthalmol. Vis. Sci., 57, 2629

Sorted by citations

Microglia in Retinal Degeneration
Rashid, K., Akhtar‐Schäfer, I., & Langmann, T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01975 · Cited by 365
“Once in the subretinal space, microglia and other mononuclear phagocytes enhance their phagocytic capacity and produce high levels of pro-inflammatory factors including IL-1β, TNF-α, IL-6, CCL2, and iNOS (100).”
Background
VEGFR1 signaling in retinal angiogenesis and microinflammation
Uemura, A., Fruttiger, M., D'Amore, P. A., Falco, S. D., Joussen, A. M., Sennlaub, F., Brunck, L. R., Johnson, K. T. M., Lambrou, G. N., Rittenhouse, K. D., et al. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100954 · Cited by 360
“Both large classical drusen and reticular drusen are characterized by the accumulation of mononuclear phagocytes in the subretinal space (Combadiere et al., 2007; Eandi et al., 2016; Greferath et al., 2016; Guillonneau et al., 2017; Levy et al., 2015a; Sennlaub et al., 2013).”
BackgroundSelf-citation
Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities
Mettu, P. S., Allingham, M. J., & Cousins, S. W. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100906 · Cited by 370
Microglia in the Retina: Roles in Development, Maturity, and Disease
Silverman, S. M., & Wong, W. T. (2018) · Annual Review of Vision Science · doi:10.1146/annurev-vision-091517-034425 · Cited by 364
Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation
Hata, M., Andriessen, E. M. M. A., Hata, M., Diaz-Marin, R., Fournier, F., Crespo‐Garcia, S., Blot, G., Juneau, R., Pilon, F., Dejda, A., et al. (2023) · Science · doi:10.1126/science.abj8894 · Cited by 195
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Authors: Guillonneau, X., Eandi, C. M., Paques, M., Sahel, J.-A., Sapieha, P., & Sennlaub, F.
Affiliations: Centre National de la Recherche Scientifique (FR)
University of Turin (IT)
Hôpital Maisonneuve-Rosemont (CA)
Corresponding author: Sennlaub, Florian
ORCID: Guillonneau, Xavier
Eandi, Chiara M.
Sahel, José-Alain
Sapieha, Przemyslaw
Sennlaub, Florian
Venue: Progress in Retinal and Eye Research
Publisher: Elsevier BV
Published: 2017-11
Volume: 61
Pages: 98-128
ISSN: 1350-9462 (ISSN-L)
DOI: 10.1016/j.preteyeres.2017.06.002
OpenAlex: W2622806731
Cited by: 185
References: 399
Citations by year: 2026: 13 · 2025: 15 · 2024: 31 · 2023: 16 · 2022: 19 · 2021: 33 · 2020: 20 · 2019: 19 · 2018: 18 · 2017: 1
FWCI: 2.91
Type: journal article
Language: en
Open access: green
hal.sorbonne-universite.fr
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Retinal and Eye Research (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Funders: INSERM
ANR Geno 2009 (R09099DS)
ANR MACLEAR (ANR-15-CE14-0015-01)
LABEX LIFESENSES (ANR-10-LABX-65)
ANR (Investissements d'Avenir programme (ANR-11-IDEX-0004-02)
Carnot
ERC (ERC-2007 St.G. 210345)
Association de Prévoyance Santé de ALLIANZ
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Keywords: age-related macular degeneration, mononuclear phagocytes, chronic inflammation, retinal pigment epithelium, photoreceptors, choroid, genetic risk factors, environmental risk factors, immunosuppression, lifestyle modification
MeSH terms: Choroid, Humans, Life Style, Macular Degeneration, Macular Edema, Phagocytes, Photoreceptor Cells, Retinal Pigment Epithelium

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