Cited by 92MicroRNA in disease regulationPI3K/AKT/mTOR signaling in cancerCancer-related molecular mechanisms research

MicroRNA-21's role in PTEN suppression and PI3K/AKT activation: Implications for cancer biology

Chawra, Himmat Singh, Agarwal, Mohit, Mishra, Anurag, Chandel, Shailendra Singh, Singh, Ravindra Pal, Dubey, Gaurav, Kukreti, Neelima, Singh, Mithilesh·2024·Pathology - Research and Practice

Abstract

MicroRNA-21 (miR-21) was recognized as a key figure in the intricate web of tumor biology, with a prominent role in regulating the PTEN tumor suppressor gene and the PI3K/AKT cascade. This review elucidates the multifaceted interactions between miR-21, PTEN, and the PI3K/AKT signaling, shedding light on their profound implications in cancer initiation, progression, and therapeutic strategies. The core of this review delves into the mechanical intricacies of miR-21-mediated PTEN suppression and its consequent impact on PI3K/AKT pathway activation. It explores how miR-21, as an oncogenic miRNA, targets PTEN directly or indirectly, resulting in uncontrolled activation of PI3K/AKT, fostering cancerous cell survival, proliferation, and evasion of apoptosis. Furthermore, the abstract emphasizes the clinical relevance of these molecular interactions, discussing their implications in various cancer types, prognostic significance, and potential as therapeutic targets. The review provides insights into ongoing research efforts to develop miR-21 inhibitors and strategies to restore PTEN function, offering new avenues for cancer treatment. This article illuminates the critical function of miR-21 in PTEN suppression and PI3K/AKT activation, offering profound insights into its implications for cancer biology and the potential for targeted interventions.

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Crossref · 10.1016/j.prp.2024.155091

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Authors
Chawra, H. S., Agarwal, M., Mishra, A., Chandel, S. S., Singh, R. P., Dubey, G., Kukreti, N., & Singh, M.
Affiliations
  • NIMS University (IN)
  • Graphic Era Hill University (IN)
Corresponding author
  • Singh, Ravindra Pal
  • Singh, Mithilesh
Venue
Pathology - Research and Practice
Publisher
Elsevier BV
Published
2024-02
Volume
254
Pages
155091
ISSN
0344-0338 (ISSN-L)
OpenAlex
W4390532016
Cited by
91
References
199
Citations by year
2026: 39 · 2025: 39 · 2024: 13
FWCI
4.44
Type
journal article
Language
en
Open access
closed
Locations
  • Pathology - Research and Practice (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
miR-21, PTEN, PI3K/Akt signaling, oncogenic microRNA, apoptosis evasion, cell proliferation, tumor progression, prognostic factors, therapeutic target, miR-21 inhibitor
MeSH terms
Biology, Humans, Neoplasms, Signal Transduction, Apoptosis, Phosphatidylinositol 3-Kinases, MicroRNAs, Cell Line, Tumor, Cell Proliferation, Proto-Oncogene Proteins c-akt, PTEN Phosphohydrolase

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