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Cited by 166Multiple Sclerosis Research StudiesTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Psychiatric Issues in Multiple Sclerosis

Open access
Chwastiak, Lydia A., Ehde, Dawn M.·2007·Psychiatric Clinics of North America
DOI 10.1016/j.psc.2007.07.003PMC PMC2706287
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Abstract

MDD and anxiety disorders are highly prevalent among persons who have MS and have been associated with decreased adherence to MS treatment and poorer functional status and quality of life. Effective treatment is available for MDD, but this disorder continues to be underdetected and undertreated by MS providers. Treatment with pharmacotherapy is particularly challenging in this patient population, given the somatic symptom overlap between MS and depression and the increased burden of side effects. Larger randomized, controlled trials are needed to elucidate further the effectiveness of pharmacotherapy and to identify subgroups of patients who would benefit from this type of treatment for depression. There have been few rigorous studies of the prevalence and impact of anxiety disorders, substance use disorders, or serious mental illness such as bipolar disorder or schizophrenia, in MS samples.

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  • Symptoms of anxiety and depression are common in multiple sclerosis and are linked to social dysfunction, decreased adherence to treatment, somatic complaints and lower functional status.

    “Symptoms of anxiety and depression are common, and linked to social dysfunction, decreased adherence to treatment, somatic complaints and lower functional status (1).”

    From Cognitive behavioural therapy in multiple sclerosis: A randomized controlled pilot study of acceptance and commitment therapy (2012) · cites this paper as [1]

    The Summary and Overview describe depression and anxiety as common in people with MS and associate them with decreased treatment adherence and poorer functional status. The Impact section also describes disruption of social support and family systems among patients with depression. The paper discusses overlap between MS and depression in somatic symptoms, but does not establish the claimed link to somatic complaints. (LLM, conf=0.88)

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  • Depression and anxiety appear to be undertreated in multiple sclerosis outpatient settings.

    “The importance of continued research in this field is illus -trated by studies suggesting that depression and anxiety appear to be undertreated in MS outpatient settings (1).”

    From Cognitive behavioural therapy in multiple sclerosis: A randomized controlled pilot study of acceptance and commitment therapy (2012) · cites this paper as [1]

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1 of the 101 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. [79]First MB, Spitzer RL, Gibbon M, et al. Structured clinical interview for Axis I DSM-IV disorders—patient edition, SCID-i/p, Version 2.0. New York: State Psychiatric Institute; 1994. [Google Scholar]
  2. [84]Fleming M, Barry K, Manwell L, et al. Brief physician advice for problem alcohol drinkers. J Am Med Assoc. 1997;277:1039–1045. [PubMed] [Google Scholar]

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Authors
Chwastiak, L. A., & Ehde, D. M.
Affiliations
  • Yale University (US)
  • University of Washington (US)
Corresponding author
Chwastiak, Lydia A.
ORCID
Venue
Psychiatric Clinics of North America
Publisher
Elsevier BV
Published
2007-12
Volume
30
Issue
4
Pages
803-817
ISSN
0193-953X (ISSN-L)
DOI
10.1016/j.psc.2007.07.003
PMC
PMC2706287
OpenAlex
W2128234760
Cited by
166
References
101
Citations by year
2026: 4 · 2025: 7 · 2024: 9 · 2023: 14 · 2022: 8 · 2021: 16 · 2020: 5 · 2019: 9 · 2018: 14 · 2017: 11 · 2016: 10 · 2015: 11 · 2014: 6 · 2013: 8 · 2012: 6
FWCI
0.56
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatric Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (K23MH077824)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
multiple sclerosis, major depressive disorder, anxiety disorders, psychiatric comorbidity, medication adherence, quality of life, pharmacotherapy side effects, substance use disorders, bipolar disorder, schizophrenia, underdiagnosis of depression
MeSH terms
Mental Disorders, Diagnosis, Differential, Humans, Multiple Sclerosis, Quality of Life, Comorbidity

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