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Cited by 334Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychotherapy Techniques and ApplicationsTreatment of Major Depression

Comparative outcomes for individual cognitive-behavior therapy, supportive-expressive group psychotherapy, and sertraline for the treatment of depression in multiple sclerosis.

Mohr, David C., Boudewyn, Arne C., Goodkin, Donald E., Bostrom, Alan, Epstein, Lucy·2001·Journal of Consulting and Clinical Psychology
DOI 10.1037/0022-006x.69.6.942
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Abstract

This study compared the efficacy of 3 16-week treatments for depression in 63 patients with multiple sclerosis (MS) and major depressive disorder (MDD): individual cognitive-behavioral therapy (CBT), supportive-expressive group therapy (SEG). and the antidepressant sertraline. Significant reductions were seen from pre- to posttreatment in all measures of depression. Intent-to-treat and completers analyses using the Beck Depression Inventory (BDI; A. T. Beck, C. H. Ward. M. Medelson. J. Mock, & J. Erbaugh, 1961) and MDD diagnosis found that CBT and sertraline were more effective than SEG at reducing depression. These results were largely supported by the BDI-18, which eliminates BDI items confounded with MS. However, the Hamilton Rating Scale for Depression (M. Hamilton, 1960) did not show consistent differences between treatments. Reasons for this inconsistency are discussed. These findings suggest that CBT or sertraline is more likely to be effective in treating MDD in MS compared with supportive group treatments.

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Crossref · 10.1037/0022-006x.69.6.942

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  • Controlled trials of behavioral interventions among patients with multiple sclerosis have focused upon treatment of depression, fatigue, or anxiety in patients selected for high symptom severity.

    “Controlled trials of behavioral interventions among patients with MS have focused upon treatment of depression, fatigue, or anxiety in patients selected for high symptom severity.16–18”

    From MS quality of life, depression, and fatigue improve after mindfulness training: A randomized trial (2010) · cites this paper as [16]

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Authors
Mohr, D. C., Boudewyn, A. C., Goodkin, D. E., Bostrom, A., & Epstein, L.
Affiliations
  • University of California, San Francisco (US)
  • Kaiser Permanente (US)
  • University of California Office of the President (US)
ORCID
Mohr, David C.
Venue
Journal of Consulting and Clinical Psychology
Publisher
American Psychological Association (APA)
Published
2001
Volume
69
Issue
6
Pages
942-949
ISSN
  • 0022-006X (ISSN-L)
  • 1939-2117
DOI
10.1037/0022-006x.69.6.942
OpenAlex
W2028940268
Cited by
334
References
84
Citations by year
2026: 7 · 2025: 4 · 2024: 4 · 2023: 9 · 2022: 2 · 2021: 9 · 2020: 11 · 2019: 11 · 2018: 8 · 2017: 24 · 2016: 19 · 2015: 20 · 2014: 13 · 2013: 24 · 2012: 23
FWCI
13.49
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Consulting and Clinical Psychology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R01-MH59708, R01MH059708)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
depression, multiple sclerosis, major depressive disorder, cognitive behavioral therapy, supportive-expressive group therapy, sertraline, antidepressant treatment, treatment efficacy comparison, Beck Depression Inventory, Hamilton Depression Rating Scale
MeSH terms
Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Male, Multiple Sclerosis, Psychotherapy, Group, Surveys and Questionnaires, Cognitive Behavioral Therapy, Selective Serotonin Reuptake Inhibitors, Sertraline

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