Quality of life in multiple sclerosis: the impact of depression, fatigue and disability
Abstract
This study deals with the assessment of quality of life and its main clinical and demographical determinants in a clinical series of 103 patients with multiple sclerosis (MS) (37 men; 66 women; mean age 44.89 years; mean disease duration 12.40 years; mean EDSS score 4.07). We used the MSQOL-54 inventory, a disease-specific instrument recently validated in an Italian population. Each patient underwent a complete clinical assessment, including that of disability status (Expanded Disability Status Scale), cognitive function (Mini Mental State Examination), depression (Hamilton Rating Scale for Depression) and fatigue (Fatigue Severity Scale). In terms of Pearson's correlations, there was a moderate inverse relationship between disability level and the MSQOL-54 physical composite score, and a moderate to strong inverse correlation between depression or fatigue severity and both the physical and mental composite scores. In a stepwise linear regression analysis, depression, fatigue and disability level were confirmed to be significant and independent predictors of quality of life. Quality of life instruments can help to provide a broader measure of the disease impact and to develop a care program tailored to the patient's needs.
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Depression has been observed to be the strongest predictor of QoL in several studies.
“Depression has been observed to be the strongest predictor in several studies [4,8,10,11,17,20,24,25,26].”
From Biopsychosocial Correlates of Quality of Life in Multiple Sclerosis Patients (2022) · cites this paper as [10]
Quality of life is reduced in people with multiple sclerosis.
“Reductions in quality of life (QOL) exist among individuals with multiple sclerosis (MS).”
From Quality of life and psychological well-being in the early stages of multiple sclerosis (MS): importance of adopting a biopsychosocial model (2018) · cites this paper as [14]
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- Authors
- Amato, M. P., Ponziani, G., Rossi, F., Liedl, C. L., Stefanile, C., & Rossi, L.
- Affiliations
- University of Florence (IT)
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2001-10
- Volume
- 7
- Issue
- 5
- Pages
- 340-344
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W2076989760
- Cited by
- 506
- References
- 7
- Citations by year
- 2026: 7 · 2025: 22 · 2024: 11 · 2023: 24 · 2022: 27 · 2021: 31 · 2020: 27 · 2019: 26 · 2018: 27 · 2017: 26 · 2016: 19 · 2015: 36 · 2014: 24 · 2013: 37 · 2012: 17
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Multiple Sclerosis Journal (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- multiple sclerosis, quality of life, depression, fatigue, disability, MSQOL-54, Expanded Disability Status Scale, Fatigue Severity Scale, cognitive function, predictors of quality of life
- MeSH terms
- Adult, Aged, Depression, Disability Evaluation, Fatigue, Female, Persons with Disabilities, Humans, Male, Middle Aged, Multiple Sclerosis, Quality of Life, Surveys and Questionnaires, Linear Models
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