Abnormal recruitment of working memory updating networks during maintenance of trauma-neutral information in post-traumatic stress disorder
Abstract
Post-traumatic stress disorder (PTSD) is characterised by disturbances in concentration and memory, symptoms which are a source of further distress for patients. Related to this, abnormalities in underlying working memory (WM) systems have been identified [Clark, C.R., McFarlane, A.C., Morris, P., Weber, D.L., Sonkkilla, C., Shaw, M.E., Marcina, J., Tochon-Danguy, H.J., Egan, G.F., 2003. Cerebral function in posttraumatic stress disorder during verbal working memory updating: a positron emission tomography study. Biological Psychiatry 53, 474-481.], indicating dysfunction in left hemisphere brain regions. In this study, we performed functional magnetic resonance imaging (fMRI) in 13 patients with severe PTSD and matched non-traumatized Controls, during performance of visuo-verbal tasks that involved either maintenance or continual updating of word stimuli in WM. The PTSD group failed to show differential activation during WM updating, and instead appeared to show abnormal recruitment of WM updating network regions during WM maintenance. These regions included the bilateral dorsolateral prefrontal cortex (DLPFC) and the inferior parietal lobe (IPL). Several other regions were significantly more activated in Controls than in PTSD during WM updating, including the hippocampus, the anterior cingulate (AC), and the brainstem pons, key regions that are consistently implicated in the neurobiology of PTSD. These findings suggest compensatory recruitment of networks in PTSD normally only deployed during updating of WM and may reflect PTSD patients' difficulty engaging with their day-to-day environment.
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Patients with PTSD show exaggerated activity in both the amygdala and hippocampus while recollecting negative autobiographical memories and while viewing negative pictures, and the degree of this hyperactivity correlated with symptom severity.
“For example, patients with PTSD show exaggerated activity in both the amygdala and hippocampus while recollecting negative autobiographical memories65 and while viewing negative pictures,66 and the degree of this hyperactivity correlated with symptom severity.66”
From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [66]
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- Authors
- Moores, K. A., Clark, C. R., McFarlane, A. C., Brown, G. C., Puce, A., & Taylor, D. J.
- Affiliations
- Flinders University (AU)
- The University of Adelaide (AU)
- West Virginia University (US)
- Royal Adelaide Hospital (AU)
- Corresponding author
- Clark, C. Richard
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 163
- Issue
- 2
- Pages
- 156-170
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W1968696218
- Cited by
- 125
- References
- 73
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 3 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 10 · 2015: 5 · 2014: 13 · 2013: 10 · 2012: 10
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Flinders Academic Commons (Flinders University) (submittedVersion)
- Funders
- Medical Research Council
- Australian Research Council
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- post-traumatic stress disorder, working memory, memory updating, memory maintenance, dorsolateral prefrontal cortex, inferior parietal lobule, hippocampus, anterior cingulate cortex, compensatory neural recruitment
- MeSH terms
- Adult, Attention, Brain, Brain Mapping, Dominance, Cerebral, Female, Gyrus Cinguli, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Middle Aged, Nerve Net, Parietal Lobe, Pons, Psychomotor Performance, Recruitment, Neurophysiological, Semantics, Stress Disorders, Post-Traumatic, Verbal Learning, Prefrontal Cortex, Imaging, Three-Dimensional, Positron-Emission Tomography
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