Cited by 113Treatment of Major DepressionDementia and Cognitive Impairment ResearchNeural and Behavioral Psychology Studies

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Pattern of brain atrophy in elderly patients with depression revealed by voxel-based morphometry

Egger, Karl, Schocke, Michael, Weiss, Elisabeth, Auffinger, Simone, Esterhammer, Regina, Goebel, Georg, Walch, Thomas, Mechtcheriakov, Sergei, Marksteiner, Josef·2008·Psychiatry Research Neuroimaging

DOI 10.1016/j.pscychresns.2007.12.018

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Abstract

In this study, we explored to what extent brain abnormalities can be identified in specific brain structures of patients suffering from late onset depression. We examined the structural difference in regional gray and white matter volume between 14 community-dwelling patients suffering from geriatric depression and 20 age-matched non-depressed normal subjects by voxel-based morphometry (VBM) based on magnetic resonance imaging. All subjects also underwent an extensive neuropsychological assessment. Compared with control subjects, patients with depression were impaired in measures of verbal and visual memory, construction, executive ability, and information-processing speed. VBM of gray matter revealed a significant decrease of volume in the right rostral hippocampus, in the right amygdala and in the medial orbito-frontal cortex (gyrus rectus) bilaterally. In the correlation analysis of gray matter volume with the score of the geriatric depression scale, we observed a negative correlation with the medial orbito-frontal cortex (gyrus rectus) bilaterally. There were no differences in white matter volumes between patients with depression and healthy control subjects. The most important limitation of this study was sample size. A larger sample size may have improved detection of changes not reaching significance. Furthermore, our results may not be generalizable across depression severity or to hospitalized patients. The findings are consistent with our hypothesis that depression in the elderly is associated with local gray matter dysfunction.

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Authors: Egger, K., Schocke, M., Weiss, E., Auffinger, S., Esterhammer, R., Goebel, G., Walch, T., Mechtcheriakov, S., & Marksteiner, J.
Affiliations: Innsbruck Medical University (AT)
Klinikum Klagenfurt (AT)
Corresponding author: Marksteiner, Josef
ORCID: Egger, Karl
Weiss, Elisabeth
Mechtcheriakov, Sergei
Venue: Psychiatry Research Neuroimaging
Publisher: Elsevier BV
Published: 2008-12
Volume: 164
Issue: 3
Pages: 237-244
ISSN: 0925-4927 (ISSN-L)
DOI: 10.1016/j.pscychresns.2007.12.018
OpenAlex: W2047189322
Cited by: 113
References: 47
Citations by year: 2025: 3 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 8 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 9 · 2014: 9 · 2013: 15 · 2012: 13
FWCI: 4.44
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychiatry Research Neuroimaging (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: geriatric depression, late-onset depression, brain atrophy, gray matter volume, white matter volume, hippocampus, amygdala, medial orbitofrontal cortex, cognitive impairment, executive function, memory impairment, voxel-based morphometry
MeSH terms: Aged, Aged, 80 and over, Amygdala, Atrophy, Brain, Cognition Disorders, Depression, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Prefrontal Cortex

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Pattern of brain atrophy in elderly patients with depression revealed by voxel-based morphometry

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