Abnormal brain anatomical topological organization of the cognitive‐emotional and the frontoparietal circuitry in major depressive disorder
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Purpose: Despite the increasing understanding of major depressive disorder (MDD) using neuroimaging techniques, the topological organization of anatomical networks underlying MDD remains unclear. Methods: The topological organization of brain anatomical networks was explored using complex network approaches. Diffusion tensor image data of 29 MDD patients and 30 healthy controls were collected. Network metrics such as strength, efficiency, and centrality were computed after the construction of brain anatomical networks. Between‐group differences and correlations with clinical measurements were further explored. Results: Compared with the healthy controls, MDD patients exhibited widely damaged information interactions in both cognitive‐emotional circuitry and frontoparietal circuitry. Moreover, the centralities in the right prefrontal cortex involving the right middle frontal gyrus and the right gyrus rectus were negatively correlated with the duration of disease. Additionally, the centrality in the right inferior frontal gyrus (triangular part) and the efficiency in the right superior frontal gyrus (orbital part) were both positively related to the depression severity. Conclusion: These findings suggest that altered connectivity involved in affective and cognitive processing procedures might contribute to the pathogenesis of MDD. Magn Reson Med 72:1397–1407, 2014. © 2013 Wiley Periodicals, Inc.
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Studies of topological organization in depressed individuals using anatomical, resting-state, and task-based functional connectivity have found disruption to the fronto-parietal network.
“Studies of topological organization in depressed individuals using anatomical80, resting-state81, and task-based functional connectivity82 have found disruption to this same fronto-parietal network.”
From Paying attention to attention in depression (2019) · cites this paper as [80]
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Defocused mode in depressed mood and its changes in time-frequency attention-related beta
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- Authors
- Qin, J., Wei, M., Liu, H., Yan, R., Luo, G., Yao, Z., & Lu, Q.
- Affiliations
- Southeast University (CN)
- Nanjing Brain Hospital (CN)
- Research Centre for Learning Science Southeast University Nanjing China
- ORCID
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2013-11-22
- Volume
- 72
- Issue
- 5
- Pages
- 1397-1407
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2146165198
- Cited by
- 73
- References
- 39
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 5 · 2019: 12 · 2018: 9 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 1
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Magnetic Resonance in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- The National Natural Science Foundation of China (81371552, 61372032)
- Jiangsu Clinical Medicine Technology Foundation (BL2012052)
- Jiangsu Natural Science Foundation (BK2012740)
- University graduates' Scientific Research Innovation Project of Jiangsu (CXLX13_116)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- major depressive disorder, network topology, diffusion tensor imaging, network centrality, network efficiency, prefrontal cortex, disease duration, depression severity, white matter connectivity
- MeSH terms
- Adult, Brain, Brain Mapping, Major Depressive Disorder, Female, Humans, Image Interpretation, Computer-Assisted, Male, Middle Aged, Psychiatric Status Rating Scales, Case-Control Studies, Diffusion Tensor Imaging
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