Cited by 73Functional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and ApplicationsMental Health Research Topics

Abnormal brain anatomical topological organization of the cognitive‐emotional and the frontoparietal circuitry in major depressive disorder

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Qin, Jiaolong, Wei, Maobin, Liu, Haiyan, Yan, Rui, Luo, Guoping, Yao, Zhijian, Lu, Qing·2014·Magnetic Resonance in Medicine

Abstract

Purpose: Despite the increasing understanding of major depressive disorder (MDD) using neuroimaging techniques, the topological organization of anatomical networks underlying MDD remains unclear. Methods: The topological organization of brain anatomical networks was explored using complex network approaches. Diffusion tensor image data of 29 MDD patients and 30 healthy controls were collected. Network metrics such as strength, efficiency, and centrality were computed after the construction of brain anatomical networks. Between‐group differences and correlations with clinical measurements were further explored. Results: Compared with the healthy controls, MDD patients exhibited widely damaged information interactions in both cognitive‐emotional circuitry and frontoparietal circuitry. Moreover, the centralities in the right prefrontal cortex involving the right middle frontal gyrus and the right gyrus rectus were negatively correlated with the duration of disease. Additionally, the centrality in the right inferior frontal gyrus (triangular part) and the efficiency in the right superior frontal gyrus (orbital part) were both positively related to the depression severity. Conclusion: These findings suggest that altered connectivity involved in affective and cognitive processing procedures might contribute to the pathogenesis of MDD. Magn Reson Med 72:1397–1407, 2014. © 2013 Wiley Periodicals, Inc.

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  • Studies of topological organization in depressed individuals using anatomical, resting-state, and task-based functional connectivity have found disruption to the fronto-parietal network.

    “Studies of topological organization in depressed individuals using anatomical80, resting-state81, and task-based functional connectivity82 have found disruption to this same fronto-parietal network.”

    From Paying attention to attention in depression (2019) · cites this paper as [80]

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  1. American Psychiatric Association Press. DSM-IV: Diagnostic and sta- tistical manual of mental disorders. 4th ed. Washington, DC: Ameri- can Psychiatric Association Press; 1994.
  2. Leistedt SJJ, Coumans N, Dumont M, Lanquart J, Stam CJ, Linkowski P. Altered sleep brain functional connectivity in acutely depressed patients. Hum Brain Mapp 2009;30:2207-2219.
  3. Jin C, Gao C, Chen C, Ma S, Netra R, Wang Y, Zhang M, Li D. A pre- liminary study of the dysregulation of the resting networks in first- episode medication-naive adolescent depression. Neurosci Lett 2011; 503:105-109.
  4. Tao H, Guo S, Ge T, Kendrick KM, Xue Z, Liu Z, Feng J. Depression uncouples brain hate circuit. Mol Psychiatry 2011;18:101-111.
  5. Hellige JB. Hemispheric asymmetry. Cambridge: Harvard University Press; 1993.

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Authors
Qin, J., Wei, M., Liu, H., Yan, R., Luo, G., Yao, Z., & Lu, Q.
Affiliations
  • Southeast University (CN)
  • Nanjing Brain Hospital (CN)
  • Research Centre for Learning Science Southeast University Nanjing China
Venue
Magnetic Resonance in Medicine
Publisher
Wiley
Published
2013-11-22
Volume
72
Issue
5
Pages
1397-1407
ISSN
  • 0740-3194 (ISSN-L)
  • 1522-2594
OpenAlex
W2146165198
Cited by
73
References
39
Citations by year
2026: 3 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 5 · 2019: 12 · 2018: 9 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 1
FWCI
2.73
Type
journal article
Language
en
Open access
Locations
  • Magnetic Resonance in Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • The National Natural Science Foundation of China (81371552, 61372032)
  • Jiangsu Clinical Medicine Technology Foundation (BL2012052)
  • Jiangsu Natural Science Foundation (BK2012740)
  • University graduates' Scientific Research Innovation Project of Jiangsu (CXLX13_116)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords
major depressive disorder, network topology, diffusion tensor imaging, network centrality, network efficiency, prefrontal cortex, disease duration, depression severity, white matter connectivity
MeSH terms
Adult, Brain, Brain Mapping, Major Depressive Disorder, Female, Humans, Image Interpretation, Computer-Assisted, Male, Middle Aged, Psychiatric Status Rating Scales, Case-Control Studies, Diffusion Tensor Imaging

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