The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.
Anterior cingulate volume in adolescents with first-presentation borderline personality disorder
Abstract
Reports of volumetric abnormalities in the anterior cingulate cortex (ACC) in adults with established borderline personality disorder (BPD) are inconsistent, and it is not known whether such abnormalities are present early in the disorder. We aimed to investigate ACC volume in a first-presentation teenage BPD sample with minimal exposure to treatment. Fifteen female BPD patients and 15 healthy female control participants underwent magnetic resonance imaging (MRI) scanning. ACC volumes were estimated using a reliable method that accounts for inter-individual variation in sulcal morphology, and measurements were compared between the two groups. Analysis of variance revealed a decrease in volume of the left ACC in BPD patients compared with control participants. This volumetric change was correlated with parasuicidal behavior and impulsivity. A measure of ACC volume asymmetry was also correlated with fear of abandonment symptoms. Our results suggest that ACC volumetric abnormalities early in the course of BPD might be related to clinical correlates of the disorder. Longitudinal studies are needed to examine the nature of this abnormality over the course of the disorder.
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In the citing paper
“there is reduced anterior cingulate cortex volume related to STB and NSSI.”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [69]
In the citing paper
“Among adolescents with BPD, a greater number of lifetime parasuicidal behaviors in the past 6 months associates with smaller left ACC volume (69), consistent with findings comparing past-year self-injurers and healthy youth (64).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [69]
In the citing paper
“By contrast, NSSI research reveals ACC structural alterations (64, 69) as well as disruptions in amygdala and ACC connectivity (96), which contributes to hyperarousal and reduced impulse control—central features of NSSI (110, 111).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [69]
Citations
Cites
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Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
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Anterior Cingulate Conflict Monitoring and Adjustments in Control
Kerns, J. G., Cohen, J. D., MacDonald, A. W., Cho, R. Y., Stenger, V. A., & Carter, C. S. (2004) · Science · doi:10.1126/science.1089910 · Cited by 2,891
Subgenual prefrontal cortex abnormalities in mood disorders
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Allman, J. M., Hakeem, A. Y., Erwin, J. M., Nimchinsky, E. A., & Hof, P. R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03476.x · Cited by 922
Neural mechanisms of genetic risk for impulsivity and violence in humans
Meyer-Lindenberg, A., Buckholtz, J. W., Kolachana, B., R. Hariri, A., Pezawas, L., Blasi, G., Wabnitz, A., Honea, R., Verchinski, B., Callicott, J. H., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511311103 · Cited by 876
“Voxel-Based Morphometry” Should Not Be Used with Imperfectly Registered Images
Bookstein, F. L. (2001) · NeuroImage · doi:10.1006/nimg.2001.0770 · Cited by 665
Velakoulis, D., Wood, S., Wong, M., McGorry, P., Yung, A., Phillips, L., Smith, D., Brewer, W., Proffitt, T., Desmond, P., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.2.139 · Cited by 630
Cited by
Sorted by citations
Borderline personality disorder in adolescence
Kaess, M., Brunner, R., & Chanen, A. (2014) · Pediatrics · doi:10.1542/peds.2013-3677 · Cited by 386
Developmental Pathways to Borderline Personality Disorder
Chanen, A. M., & Kaess, M. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0242-y · Cited by 303
“Two studies found reduced orbitofrontal cortex (OFC) volumes [31, 32•], and two studies found decreased anterior cingulate cortex (ACC) volume [33, 34].”
BackgroundChanen, A. M., & McCutcheon, L. (2013) · British Journal of Psychiatry · doi:10.1192/bjp.bp.112.119180 · Cited by 262
Sharp, C., & Fonagy, P. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12449 · Cited by 237
“Similar to findings in adults, structural imaging research in adolescents with BPD has demonstrated volume reduction in the frontolimbic network, including the orbitofrontal cortex (Brunner et al., 2010; Chanen, Velakoulis, et al., 2008), and the ACC (Goodman et al., 2011; Whittle et al., 2009).”
ResultThe Latest Neuroimaging Findings in Borderline Personality Disorder
Krause-Utz, A., Winter, D., Niedtfeld, I., & Schmahl, C. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0438-z · Cited by 235
“Another group investigated adolescents with regard to the volumes of hippocampus, amygdala [28], ACC [ 29 ], midline brain [30], and insula [31].”
Background
Metadata
- Authors
- Whittle, S., Chanen, A. M., Fornito, A., McGorry, P. D., Pantelis, C., & Yücel, M.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Yücel, Murat
- Venue
- Psychiatry Research Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 172
- Issue
- 2
- Pages
- 155-160
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2023217661
- Cited by
- 105
- References
- 56
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 4 · 2014: 11 · 2013: 10 · 2012: 11
- FWCI
- 10.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- borderline personality disorder, anterior cingulate cortex, brain volume, adolescents, initial presentation, parasuicide, impulsivity, fear of abandonment, hemispheric lateralization, sulcal morphology, neuroanatomical correlates
- MeSH terms
- Adolescent, Age Factors, Atrophy, Borderline Personality Disorder, Brain, Brain Mapping, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Functional Laterality, Limbic System, Magnetic Resonance Imaging, Young Adult
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