fMRI brain activation during a delay discounting task in HIV-positive adults with and without cocaine dependence
Open accessAbstract
Cocaine use is associated with poorer HIV clinical outcomes and may contribute to neurobiological impairments associated with impulsive decision making. This study examined the effect of cocaine dependence on brain activation during a delay discounting task involving choices between smaller immediate rewards and larger delayed ones. Participants were 39 HIV-positive adults on antiretroviral therapy who had current cocaine dependence ("active," n=15), past cocaine dependence ("recovered," n=13), or no lifetime substance dependence ("naïve," n=11). Based on responses on a traditional delay discounting task, three types of choices were individualized for presentation during functional magnetic resonance imaging: hard (similarly valued), easy (disparately valued), and no (single option). Active participants had significantly smaller increases in activation than naïve participants during hard versus easy choices bilaterally in the precentral gyrus and anterior cingulate cortex and in the right frontal pole (including dorsolateral, ventrolateral, and orbitofrontal cortex). During hard and easy choices relative to no choices, active participants had smaller increases in activation compared to naïve participants in frontoparietal cortical regions. These deficits in the executive network during delay discounting choices may contribute to impulsive decision making among HIV-positive cocaine users, with implications for risk behaviors associated with disease transmission and progression.
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Meade et al. (2011) found that significantly less executive system activation was observed in active cocaine users than both former and never users.
“Significantly less executive system activation was observed in the active cocaine users than both the former and never users (Hoffman et al., 2006; Monterosso et al., 2007a).”
From Excessive discounting of delayed reinforcers as a trans-disease process contributing to addiction and other disease-related vulnerabilities: Emerging evidence (2012) · cites this paper as Meade et al. (2011)
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- Authors
- Meade, C. S., Lowen, S. B., MacLean, R. R., Key, M. D., & Lukas, S. E.
- Affiliations
- Harvard University (US)
- McLean Hospital (US)
- Duke University (US)
- Corresponding author
- Meade, Christina S.
- Venue
- Psychiatry Research Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 192
- Issue
- 3
- Pages
- 167-175
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC3097316
- OpenAlex
- W2031514129
- Cited by
- 79
- References
- 67
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 10 · 2014: 5 · 2013: 8 · 2012: 7
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- amfAR, The Foundation for AIDS Research
- Harvard University Center for AIDS Research
- National Institute on Drug Abuse (K05DA000343, K05DA00343, K25DA016612, T32 DA01536, T32DA015036)
- National Institute of Allergy and Infectious Diseases (P30 AI 60354, P30AI060354)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- delay discounting, cocaine dependence, HIV, impulsivity, decision-making, executive function, anterior cingulate cortex, orbitofrontal cortex, frontal pole, precentral gyrus, frontoparietal cortex, antiretroviral therapy, substance use, HIV risk factors
- MeSH terms
- Adult, Analysis of Variance, Brain, Brain Mapping, Choice Behavior, Decision Making, Female, HIV Seropositivity, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Oxygen, Surveys and Questionnaires, Time Factors, Chi-Square Distribution, Cocaine-Related Disorders, Young Adult
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