Cortical activation during delay discounting in abstinent methamphetamine dependent individuals
Open accessAbstract
Background Methamphetamine (MA)-dependent individuals prefer smaller immediate over larger delayed rewards in delay discounting (DD) tasks. Human and animal data implicate ventral (amygdala, ventral striatum, ventrolateral prefrontal cortex insula) and dorsal (dorsolateral prefrontal cortex, dorsal anterior cingulate cortex and posterior parietal cortex) systems in DD decisions. The ventral system is hypothesized to respond to the salience and immediacy of rewards while the dorsal system is implicated in the process of comparison and choice.Methods We used functional Magnetic Resonance Imaging to probe the neural correlates of DD in 19 recently abstinent MA-dependent patients and 17 age- and gender-matched controls.Results Hard DD choices were associated with greatest activation in bilateral middle cingulate, posterior parietal cortex (PPC), and the right rostral insula. Control subjects showed more activation than MA patients bilaterally in the precuneus and in the right caudate nucleus, anterior cingulate cortex (ACC), and dorsolateral prefrontal cortex (DLPFC). Magnitude of discounting was correlated with activity in the amygdala, DLPFC, posterior cingulate cortex and PPC.Conclusions Our findings were consistent with a model wherein dorsal cognitive systems modulate the neural response of ventral regions. Patients addicted to MA, who strongly prefer smaller immediate over larger delayed rewards, activate the dorsal cognitive control system in order to overcome their preference. Activation of the amygdala during choice of delayed rewards was associated with a greater degree of discounting, suggesting that heavily discounting MA-dependent individuals may be more responsive to the negative salience of delayed rewards than controls.
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Insula and anterior cingulate activation are atypical in individuals with addiction disorders during decision-making and risk-taking.
“Similarly, insula and anterior cingulate activation have been found to be atypical in individuals with addiction disorders during decision-making and risk-taking (Gowin et al., 2014; Hoffman et al., 2008; London et al., 2005; Nestor et al., 2011; Paulus, Hozack, et al., 2003).”
From Atypical interoception as a common risk factor for psychopathology: A review (2021) · cites this paper as Hoffman et al., 2008
The Results (MA group vs. control group; page unavailable) identify a difference in right anterior cingulate activation during delay-discounting decisions. The Results (Functional MRI; page unavailable) report insula activation during difficult decisions in the combined groups, but do not identify atypical insula activation in the methamphetamine-dependent group. The study also addresses delay-discounting decisions, not risk-taking broadly. (LLM, conf=0.87)
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- Authors
- Hoffman, W. F., Schwartz, D. L., Huckans, M. S., McFarland, B. H., Meiri, G., Stevens, A. A., & Mitchell, S. H.
- Affiliations
- Oregon Health & Science University (US)
- United States Department of Veterans Affairs (US)
- Ben-Gurion University of the Negev (IL)
- Corresponding author
- Hoffman, William F.
- ORCID
- Venue
- Psychopharmacology
- Published
- 2008-08-07
- Volume
- 201
- Issue
- 2
- Pages
- 183-193
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC2835463
- OpenAlex
- W2054590164
- Cited by
- 210
- References
- 51
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 11 · 2021: 8 · 2020: 9 · 2019: 10 · 2018: 8 · 2017: 16 · 2016: 11 · 2015: 14 · 2014: 19 · 2013: 17 · 2012: 27
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (DA015543, P50DA018165, R01DA015543)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- delay discounting, methamphetamine dependence, abstinence, amygdala, dorsolateral prefrontal cortex, posterior parietal cortex, anterior cingulate cortex, posterior cingulate cortex, insula, caudate nucleus, precuneus, delayed rewards, impulsivity, neural correlates of decision making
- MeSH terms
- Adult, Amygdala, Choice Behavior, Data Interpretation, Statistical, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Models, Anatomic, Parietal Lobe, Behavior, Addictive, Prefrontal Cortex, Amphetamine-Related Disorders
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