Resting state functional connectivity and treatment response in late-life depression
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Indices of functional connectivity in the default mode network (DMN) are promising neural markers of treatment response in late-life depression. We examined the differences in DMN functional connectivity between treatment-responsive and treatment-resistant depressed older adults. Forty-seven depressed older adults underwent MRI scanning pre- and post-pharmacotherapy. Forty-six never depressed older adults underwent MR scanning as comparison subjects. Treatment response was defined as achieving a Hamilton Depression Rating Scale of 10 or less post-treatment. We analyzed resting state functional connectivity using the posterior cingulate cortex as the seed region-of-interest. The resulting correlation maps were employed to investigate between-group differences. Additionally we examined the association between white matter hyperintensity burden and functional connectivity results. Comparison of pre- and post-treatment scans of depressed participants revealed greater post-treatment functional connectivity in the frontal precentral gyrus. Relative to treatment-responsive participants, treatment-resistant participants had increased functional connectivity in the left striatum. When adjusting for white matter hyperintensity burden, the observed differences lost significance for the PCC-prefrontal functional connectivity, but not for the PCC-striatum functional connectivity. The post-treatment "frontalization" of the DMN connectivity suggests a normalizing effect of antidepressant treatment. Moreover, our study confirms the central role of white matter lesions in disrupting brain functional connectivity.
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The results of studies examining the impact of antidepressant medication initiation on connectivity are heterogeneous.
“The results of studies examining the impact of ADM initiation on connectivity are heterogeneous28–39.”
From The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse (2020) · cites this paper as [30]
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- Authors
- Andreescu, C., Tudorascu, D. L., Butters, M. A., Tamburo, E., Patel, M., Price, J., Karp, J. F., Reynolds, C. F., & Aizenstein, H.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Andreescu, Carmen
- ORCID
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 214
- Issue
- 3
- Pages
- 313-321
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC3865521
- OpenAlex
- W2037229172
- Cited by
- 153
- References
- 61
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 11 · 2021: 34 · 2020: 11 · 2019: 14 · 2018: 14 · 2017: 8 · 2016: 10 · 2015: 13 · 2014: 4 · 2013: 1
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000005, KL2TR000146)
- National Institute on Aging (P01AG025204, RF1AG025516, R01AG033575, AG033575, R37AG025516)
- National Institute of Mental Health (P30MH090333, MH-071944, P30 MH90333, R01MH076079, R01MH080240, P30MH071944, MH080240, MH086686, K23MH086686)
- National Institute of Neurological Disorders and Stroke (R21NS060184)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- geriatric depression, resting-state functional connectivity, default mode network, treatment response, treatment-resistant depression, antidepressant treatment, posterior cingulate cortex, white matter hyperintensities, striatum, prefrontal cortex, older adults, neural markers
- MeSH terms
- Adult, Aged, Antidepressive Agents, Brain, Brain Mapping, Depressive Disorder, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Fibers, Myelinated, Rest, Case-Control Studies, Treatment Outcome, Neostriatum, Age of Onset
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