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Cited by 16Functional Brain Connectivity StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesObsessive-Compulsive Spectrum Disorders

Resting functional connectivity in social anxiety disorder and the effect of pharmacotherapy

Doruyter, Alexander, Lochner, Christine, Jordaan, Gerhard P., Stein, Dan J., Dupont, Patrick, Warwick, James M.·2016·Psychiatry Research Neuroimaging
DOI 10.1016/j.pscychresns.2016.04.009
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Abstract

Neuroimaging research has reported differences in resting-state functional connectivity (RFC) between social anxiety disorder (SAD) patients and healthy controls (HCs). Limited research has examined the effect of treatment on RFC in SAD. We performed a study to identify differences in RFC between SAD and HC groups, and to investigate the effect of pharmacotherapy on RFC in SAD. Seed-based RFC analysis was performed on technetium-99m hexamethylpropylene amine oxime (Tc-99m HMPAO) SPECT scans using a cross-subject approach in SPM-12. Seeds were chosen to represent regions in a recently published network model of SAD. A second-level regression analysis was performed to further characterize the underlying relationships identified in the group contrasts. Twenty-three SAD participants were included, of which 18 underwent follow-up measures after an 8-week course of citalopram or moclobemide. Fifteen healthy control (HC) scans were included. SAD participants at baseline demonstrated several significant connectivity disturbances consistent with the existing network model as well as one previously unreported finding (increased connectivity between cerebellum and posterior cingulate cortex). After therapy, the SAD group demonstrated significant increases in connectivity with dorsal anterior cingulate cortex which may explain therapy-induced modifications in how SAD sufferers interpret emotions in others and improvements in self-related and emotional processing.

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  • Medical interventions, including SSRIs and other pharmacological treatments, as well as exposure-based CBT, have been shown to affect and in part normalise important aspects of such dysfunctions and imbalances.

    “Medical interventions, including SSRIs [e.g.(Doruyter et al., 2016;Schmidt et al., 2018)], and other pharmacological treatments (Fig. 3), as well as (exposure-based) CBT [e.g.(Brooks & Stein, 2015;King et al., 2016;Neufang et al., 2019;Steiger et al., 2017); see scheme in Excursus 2 in (Sartori & Singewald, 2017)] have been shown to affect and in part normalise important aspects of such dysf”

    From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Doruyter et al., 2016

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Authors
Doruyter, A., Lochner, C., Jordaan, G. P., Stein, D. J., Dupont, P., & Warwick, J. M.
Affiliations
  • Stellenbosch University (ZA)
  • University of Cape Town (ZA)
  • KU Leuven (BE)
ORCID
Venue
Psychiatry Research Neuroimaging
Publisher
Elsevier BV
Published
2016-05
Volume
251
Pages
34-44
ISSN
0925-4927 (ISSN-L)
DOI
10.1016/j.pscychresns.2016.04.009
OpenAlex
W2337922010
Cited by
16
References
88
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 5 · 2016: 2
FWCI
1.91
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
Funders
South African Medical Research Council
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Keywords
social anxiety disorder, resting-state functional connectivity, pharmacotherapy, citalopram, moclobemide, cerebellum, posterior cingulate cortex, dorsal anterior cingulate cortex, emotional processing, social cognition, brain network models
MeSH terms
Phobia, Social, Adult, Antidepressive Agents, Brain, Emotions, Female, Gyrus Cinguli, Humans, Male, Rest, Citalopram, Tomography, Emission-Computed, Single-Photon, Treatment Outcome, Technetium Tc 99m Exametazime, Moclobemide, Neuroimaging

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