Antenatal depression, treatment with selective serotonin reuptake inhibitors, and neonatal brain structure: A propensity-matched cohort study
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The aim of this propensity-matched cohort study was to evaluate the impact of prenatal SSRI exposure and a history of maternal depression on neonatal brain volumes and white matter microstructure. SSRI-exposed neonates (n=27) were matched to children of mothers with no history of depression or SSRI use (n=54). Additionally, neonates of mothers with a history of depression, but no prenatal SSRI exposure (n=41), were matched to children of mothers with no history of depression or SSRI use (n=82). Structural magnetic resonance imaging and diffusion weighted imaging scans were acquired with a 3T Siemens Allegra scanner. Global tissue volumes were characterized using an automatic, atlas-moderated expectation maximization segmentation tool. Local differences in gray matter volumes were examined using deformation-based morphometry. Quantitative tractography was performed using an adaptation of the UNC-Utah NA-MIC DTI framework. SSRI-exposed neonates exhibited widespread changes in white matter microstructure compared to matched controls. Children exposed to a history of maternal depression but no SSRIs showed no significant differences in brain development compared to matched controls. No significant differences were found in global or regional tissue volumes. Additional research is needed to clarify whether SSRIs directly alter white matter development or whether this relationship is mediated by depressive symptoms during pregnancy.
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Maternal depression and selective serotonin-uptake inhibitor use during pregnancy are associated with reduced FA across many white-matter tracts in neonates.
“Maternal depression and use of selective serotonin-uptake inhibitors during pregnancy is associated with reduced FA across many white-matter tracts in neonates177.”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [177]
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Imaging structural and functional brain development in early childhood
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“It also relates to higher connectivity in putative auditory resting-state networks [163] and lower fractional anisotropy, increased mean and radial diffusivity for multiple white matter fi ber bundles in newborns [164].”
BackgroundPrenatal Antidepressant Exposure and Offspring Brain Morphologic Trajectory
Koc, D., Tiemeier, H., Stricker, B. H., Muetzel, R. L., Hillegers, M., & El Marroun, H. (2023) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2023.3161 · Cited by 44 · see citing works
- Authors
- Jha, S. C., Meltzer-Brody, S., Steiner, R. J., Cornea, E., Woolson, S., Ahn, M., Verde, A. R., Hamer, R. M., Zhu, H., Styner, M., Gilmore, J. H., & Knickmeyer, R. C.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Vanderbilt University (US)
- Durham VA Medical Center (US)
- University of Nevada, Reno (US)
- Corresponding author
- Knickmeyer, Rebecca C.
- ORCID
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 253
- Pages
- 43-53
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC4930375
- OpenAlex
- W2407139864
- Cited by
- 66
- References
- 48
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 6 · 2017: 5 · 2016: 2
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (MH064065, MH070890, MH083045, MH085165, SES-1357666, DMS-1407655, 1μL1TR001111, MH086633, HD-003110, EB005149, NS007431)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- antenatal depression, maternal depression, selective serotonin reuptake inhibitors, prenatal SSRI exposure, white matter microstructure, gray matter volume, brain tissue volume, diffusion tensor imaging, tractography, brain development, pregnancy
- MeSH terms
- Adult, Brain, Depressive Disorder, Female, Humans, Infant, Newborn, Male, Organ Size, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Utah, Cohort Studies, Selective Serotonin Reuptake Inhibitors, Diffusion Tensor Imaging, White Matter, Gray Matter
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