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Cited by 161Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychological Treatments and Disorders

Treatment of depression with atypical features: a meta-analytic approach

Henkel, Verena, Mergl, Roland, Allgaier, Antje-Kathrin, Kohnen, Ralph, Möller, Hans-Jürgen, Hegerl, Ulrich·2006·Psychiatry Research
DOI 10.1016/j.psychres.2005.07.012
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Abstract

The present meta-analysis addressed the empirical evidence regarding the treatment of major depression with atypical features. The superiority of monoamine oxidase inhibitors (MAOIs) compared with other antidepressants in the treatment of major depression with atypical features has been frequently reported. According to the CONSORT Statement, studies included in our meta-analysis had to meet several criteria, especially a double-blind, controlled condition and an operational diagnosis according to Diagnostic and Statistical Manual of Mental Disorders (DSM)-III or DSM-IV criteria, respectively. Four databases for research-based evidence were used in a systematic review: Medline, Embase, Psyndex and PsycInfo. Only eight publications met inclusion/exclusion criteria, resulting in 11 comparisons. Our results contrast an effect size of 0.45 (95% confidence interval) for a comparison of MAOIs vs. placebo with an effect size of 0.02 (95% confidence interval: - 0.10-0.14) for a comparison of MAOIs vs. selective serotonin reuptake inhibitors. The effect size for MAOIs vs. tricyclic antidepressants was 0.27 (95% confidence interval: 0.16-0.42). MAOIs may be more effective for atypical major depressive disorder than tricyclic antidepressants. Most clinical research has been conducted on irreversible MAOIs. Additional studies testing more recently developed antidepressants (including reversible MAOIs) with an improved safety profile would be warranted. The available data are insufficient for a direct comparison between MAOIs and selective serotonin reuptake inhibitors.

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  • Individuals with atypical depression often have a more unrelenting course of depression, in part because they show a poorer response to antidepressants.

    “Individuals with atypical depression often have a more unrelenting course of depression [13], in part because they show a poorer response to antidepressants [14].”

    From The menace of obesity to depression and anxiety prevalence (2022) · cites this paper as [14]

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Authors
Henkel, V., Mergl, R., Allgaier, A.-K., Kohnen, R., Möller, H.-J., & Hegerl, U.
Affiliations
  • Ludwig-Maximilians-Universität München (DE)
  • Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Corresponding author
Mergl, Roland
ORCID
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2006-01
Volume
141
Issue
1
Pages
89-101
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/j.psychres.2005.07.012
OpenAlex
W1986750404
Cited by
161
References
99
Citations by year
2026: 4 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 10 · 2016: 10 · 2015: 13 · 2014: 9 · 2013: 8 · 2012: 13
FWCI
0.69
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
Keywords
atypical depression, major depressive disorder, monoamine oxidase inhibitors, antidepressant treatment, selective serotonin reuptake inhibitors, tricyclic antidepressants, placebo comparison, treatment efficacy
MeSH terms
Antidepressive Agents, Major Depressive Disorder, Double-Blind Method, Humans, Monoamine Oxidase Inhibitors, Phenelzine, Severity of Illness Index, Sertraline, Moclobemide

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