Effect of anxiety on treatment presentation and outcome: Results from the marijuana treatment project
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Despite emerging evidence of the efficacy of psychotherapies for marijuana dependence, variability in outcome exists. This study examined the role of anxiety on treatment involvement and outcome. Four questions were examined: (1) Is greater anxiety associated with greater impairment at baseline? (2) Is baseline anxiety related to greater marijuana use and problems following treatment? (3) Does adding cognitive-behavioral therapy (CBT) to motivation enhancement therapy (MET) reduce anxiety relative to MET alone; (4) Are reductions in anxiety associated with better outcomes? The sample comprised 450 marijuana-dependent patients in the Marijuana Treatment Project. Marijuana use and anxiety were measured at pretreatment and 4- and 9-month follow-ups. At baseline, anxiety was linked to more marijuana-related problems. CBT was associated with less anxiety at follow-up compared to MET alone. Reductions in anxiety were related to less marijuana use. In fact, reduction in anxiety from baseline to 4-month follow-up was associated with less marijuana use at 9 months, but reduction in marijuana use did not predict subsequent anxiety. Data suggest that anxiety is an important variable that deserves further attention in marijuana-dependence treatment.
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Patients with elevated anxiety have poorer cannabis outcomes after MET-CBT, including more cannabis use and related problems.
“patients with elevated anxiety report more cannabis use and related problems following treatment (Buckner & Carroll, 2010).”
From Integrated cognitive behavioral therapy for comorbid cannabis use and anxiety disorders: A pilot randomized controlled trial (2019) · cites this paper as Buckner & Carroll, 2010
The Results (§3.2; page unavailable) link higher pretreatment anxiety to more cannabis-related problems at follow-up among women, but not men. Results (§3.4) link changes in anxiety to later cannabis use and problems, including in the CBT-MET condition. The claim overstates these findings by treating elevated anxiety as a general predictor of both greater use and more problems after CBT-MET. (LLM, conf=0.88)
Experimental — accuracy not yet measuredReductions in anxiety during cannabis use disorder treatment are associated with better outcomes.
“decreases in anxiety during CUD treatment are related to better outcomes (Buckner & Carroll, 2010)”
From Integrated cognitive behavioral therapy for comorbid cannabis use and anxiety disorders: A pilot randomized controlled trial (2019) · cites this paper as Buckner & Carroll, 2010
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Buckner, J. D., Morris, P. E., Scherzer, C. R., Ecker, A. H., & Beighley, J. S. (2024) · CBT: science into practice · doi:10.1007/978-3-031-62971-6_3 · Cited by 1 · see citing works
Self-citationChung, A. K. K., Tse, C. Y., Yeung, G. K. Y., Tang, S. W., Chan, W.-M., & Law, J. K. C. (2024) · Journal of Substance Use and Addiction Treatment · doi:10.1016/j.josat.2024.209607 · Cited by 1 · see citing works
Morris, P. E., Thomas, K. L., & Buckner, J. D. (2024) · Substance Use & Misuse · doi:10.1080/10826084.2024.2422944 · Cited by 1 · see citing works
Self-citationAcute and non-acute effects of cannabis in adolescents and adults
Mokrysz, C. (2017) · UCL Discovery (University College London)
Buckner, J. D., Ecker, A. H., Walukevich‐Dienst, K., Lewis, E. M., Pugh, E., & Abarno, C. N. (2021) · Journal of Cognitive Psychotherapy · doi:10.1891/jcpsy-d-20-00026
Self-citationSubstance Use Disorders: Second Wave Approaches
Ecker, A. H., Hogan, J., Dawson, D. B., & Cucciare, M. A. (2022) · Springer eBooks · doi:10.1007/978-3-031-11677-3_24
Coles, A. R. L., Perry, J. K., Hiscock, B. B., Fawcett, J. M., Harris, N., & Fawcett, E. J. (2025) · Journal of Dual Diagnosis · doi:10.1080/15504263.2025.2606019
Wolitzky-Taylor, K. B., & Ecker, A. H. (2026) · Behaviour Research and Therapy · doi:10.1016/j.brat.2026.105117
- Authors
- Buckner, J. D., & Carroll, K. M.
- Affiliations
- Louisiana State University (US)
- Yale University (US)
- Corresponding author
- Buckner, Julia D.
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 178
- Issue
- 3
- Pages
- 493-500
- ISSN
- 0165-1781 (ISSN-L)
- PMC
- PMC2914117
- OpenAlex
- W2072755299
- Cited by
- 55
- References
- 55
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 3 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 6
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Civil War Book Review (submittedVersion)
- Funders
- Substance Abuse and Mental Health Services Administration
- National Institute on Drug Abuse (K05-DA00457, F31DA021457, R25DA020515, R37DA015969, P50DA009241, K05DA000457, R01DA015969, P50-DA-0-9241)
- Center for Substance Abuse Treatment
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- cannabis use disorder, anxiety, treatment outcomes, treatment engagement, cognitive behavioral therapy, cannabis use, substance use disorders
- MeSH terms
- Adolescent, Adult, Anxiety, Marijuana Abuse, Female, Follow-Up Studies, Humans, Male, Middle Aged, Motivation, Retrospective Studies, Severity of Illness Index, Statistics as Topic, Time Factors, Cognitive Behavioral Therapy, Chi-Square Distribution, Treatment Outcome, Young Adult
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