Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population

Kyogoku, Chieko; Yanagi, Masaya; Nishimura, Kunihiro; Sugiyama, Daisuke; Morinobu, Akio; Fukutake, Masaaki; Maeda, Kiyoshi; Shirakawa, Osamu; Kuno, Takayoshi; Kumagai, Shunichi

doi:10.1016/j.psychres.2009.11.003

Cited by 20Schizophrenia research and treatmentGenetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior

Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population

Kyogoku, Chieko, Yanagi, Masaya, Nishimura, Kunihiro, Sugiyama, Daisuke, Morinobu, Akio, Fukutake, Masaaki, Maeda, Kiyoshi, Shirakawa, Osamu +2 more·2011·Psychiatry Research

DOI 10.1016/j.psychres.2009.11.003

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Abstract

To examine the association of PPP3CC (rs10108011 and rs2461491) and EGR3 (rs3750192) single-nucleotide polymorphisms (SNPs) with Japanese schizophrenia, we performed a case-control association study using 337 patients and 369 healthy controls. As a result, by our moderated cohort-size study, PPP3CC and EGR3 are not genetic risk factors for schizophrenia, whereas meta-analysis showed weak association of rs10108011 with schizophrenia in the Japanese population (odds ratio (OR)=1.12, P=0.01).

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Egr3 has been implicated in both schizophrenia and circadian organization.
“Another gene that has been implicated in both SZ and circadian organization is immediate early gene growth response 3 (Egr3)162,165–168.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [168]

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in Social and Environmental Medicine, Graduate
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Authors: Kyogoku, C., Yanagi, M., Nishimura, K., Sugiyama, D., Morinobu, A., Fukutake, M., Maeda, K., Shirakawa, O., Kuno, T., & Kumagai, S.
Affiliations: Kobe University (JP)
Kindai University (JP)
Corresponding author: Kyogoku, Chieko
ORCID: Yanagi, Masaya
Nishimura, Kunihiro
Sugiyama, Daisuke
Morinobu, Akio
Maeda, Kiyoshi
Shirakawa, Osamu
Kumagai, Shunichi
Venue: Psychiatry Research
Publisher: Elsevier BV
Published: 2011-01
Volume: 185
Issue: 1-2
Pages: 16-19
ISSN: 0165-1781 (ISSN-L)
DOI: 10.1016/j.psychres.2009.11.003
OpenAlex: W2115961536
Cited by: 20
References: 19
Citations by year: 2024: 1 · 2021: 1 · 2020: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 5
FWCI: 2.19
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychiatry Research (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: schizophrenia, PPP3CC, EGR3, single nucleotide polymorphisms, genetic susceptibility, Japanese population
MeSH terms: Adult, Aged, Cross-Cultural Comparison, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Schizophrenia, Meta-Analysis as Topic, Linkage Disequilibrium, Case-Control Studies, Calcineurin, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Asian People, Early Growth Response Protein 3, Genome-Wide Association Study

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Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population

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