Sex differences in mood disorders: Perspectives from humans and rodent models
Open accessAbstract
Mood disorders are devastating, often chronic illnesses characterized by low mood, poor affect, and anhedonia. Notably, mood disorders are approximately twice as prevalent in women compared to men. If sex differences in mood are due to underlying biological sex differences, a better understanding of the biology is warranted to develop better treatment or even prevention of these debilitating disorders. In this review, our goals are to: 1) summarize the literature related to mood disorders with respect to sex differences in prevalence, 2) introduce the corticolimbic brain network of mood regulation, 3) discuss strategies and challenges of modeling mood disorders in mice, 4) discuss mechanisms underlying sex differences and how these can be tested in mice, and 5) discuss how our group and others have used a translational approach to investigate mechanisms underlying sex differences in mood disorders in humans and mice.
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Female gender was noted to have higher levels of depression, anxiety and stress compared to male gender.
“the female gender was noted to have higher levels of depression, anxiety and stress as compared to the male gender.”
From Relationships between psychopathology, psychological process variables, and sociodemographic variables and comparison of quarantined and non-quarantined groups of malaysian university students in the covid-19 pandemic (2021) · cites this paper as [61]
The Review section reports that women are more likely than men to be diagnosed with major depressive disorder, and that women with MDD are more likely to have a co-morbid anxiety disorder. It also describes greater self-reported distress in stressful situations, but notes equivalent physiological stress responses in the example given. These findings do not establish generally higher levels of depression, anxiety, and stress in women as the citing sentence states. (LLM, conf=0.86)
Experimental — accuracy not yet measuredSimilar trends were reported during previous pandemics.
“Similar trends were reported during previous pandemics [61,62,63,64].”
From Relationships between psychopathology, psychological process variables, and sociodemographic variables and comparison of quarantined and non-quarantined groups of malaysian university students in the covid-19 pandemic (2021) · cites this paper as [61]
The Review section discusses sex differences in mood disorders and stress-related rodent models, not trends during previous pandemics. Searches for “pandemic” and for previous outbreaks or epidemics found no passage addressing the claim. Page numbers were not supplied in our copy. (LLM, conf=0.76)
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The Impact of Caregivers' Anxiety on Patients' Anxiety before Fast-Track Knee Arthroplasty
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- Authors
- Seney, M. L., & Sibille, E.
- Affiliations
- University of Pittsburgh (US)
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Seney, Marianne L
- Sibille, Etienne
- Venue
- Biology of Sex Differences
- Published
- 2014-12
- Volume
- 5
- Issue
- 1
- Pages
- 17-17
- ISSN
- 2042-6410 (ISSN-L)
- PMC
- PMC4268901
- OpenAlex
- W2120430663
- Cited by
- 181
- References
- 122
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 11 · 2023: 16 · 2022: 17 · 2021: 19 · 2020: 55 · 2019: 9 · 2018: 13 · 2017: 9 · 2016: 5 · 2015: 8
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Biology of Sex Differences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
- TSpace (University of Toronto) (submittedVersion)
- Funders
- National Institute of Mental Health (MH084060, MH103473, MH085111, R21MH085111, K01MH103473, K02MH084060)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- mood disorders, sex differences, depression, anhedonia, cortico-limbic network, mood regulation, rodent models, mouse model of depression, translational research, sex differences in prevalence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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