Cited by 183Neurotransmitter Receptor Influence on BehaviorTreatment of Major DepressionStress Responses and Cortisol

Sex differences in mood disorders: Perspectives from humans and rodent models

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Seney, Marianne L, Sibille, Etienne·2014·Biology of Sex Differences

Abstract

Mood disorders are devastating, often chronic illnesses characterized by low mood, poor affect, and anhedonia. Notably, mood disorders are approximately twice as prevalent in women compared to men. If sex differences in mood are due to underlying biological sex differences, a better understanding of the biology is warranted to develop better treatment or even prevention of these debilitating disorders. In this review, our goals are to: 1) summarize the literature related to mood disorders with respect to sex differences in prevalence, 2) introduce the corticolimbic brain network of mood regulation, 3) discuss strategies and challenges of modeling mood disorders in mice, 4) discuss mechanisms underlying sex differences and how these can be tested in mice, and 5) discuss how our group and others have used a translational approach to investigate mechanisms underlying sex differences in mood disorders in humans and mice.

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Authors
Seney, M. L., & Sibille, E.
Affiliations
  • University of Pittsburgh (US)
  • Centre for Addiction and Mental Health (CA)
Corresponding author
  • Seney, Marianne L
  • Sibille, Etienne
Venue
Biology of Sex Differences
Published
2014-12
Volume
5
Issue
1
Pages
17-17
ISSN
2042-6410 (ISSN-L)
OpenAlex
W2120430663
Cited by
181
References
122
Citations by year
2026: 7 · 2025: 12 · 2024: 11 · 2023: 16 · 2022: 17 · 2021: 19 · 2020: 55 · 2019: 9 · 2018: 13 · 2017: 9 · 2016: 5 · 2015: 8
FWCI
3.51
Type
journal article
Language
en
Open access
Locations
  • Biology of Sex Differences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
  • TSpace (University of Toronto) (submittedVersion)
Funders
National Institute of Mental Health (MH084060, MH103473, MH085111, R21MH085111, K01MH103473, K02MH084060)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
mood disorders, sex differences, depression, anhedonia, cortico-limbic network, mood regulation, rodent models, mouse model of depression, translational research, sex differences in prevalence

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