Possible genetic association between vasopressin receptor 1B and child aggression
Abstract
Background Studies on animal models have implicated arginine vasopressin signalling pathway in aggressive behaviour. The role of arginine vasopressin in childhood onset aggression is unclear. Methods We investigated 11 single-nucleotide polymorphisms in the genes coding for arginine vasopressin and its receptors in our sample of 177 aggressive child cases paired with adult controls matched for sex and ethnicity. Results We found the non-synonymous polymorphism AVPR1B_rs35369693 to be associated with child aggression in our sample (P=0.007). We also found two-marker haplotype window containing AVPR1B_rs35369693 and AVPR1B_rs28676508 to be associated (P=0.003). The haplotype findings survived multiple-testing adjusted significance threshold of 0.0063. Conclusions This is the first report of a genetic association between vasopressin receptor 1B and child aggression. Replication in independent samples are required to confirm these findings.
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The association of AVPR1B_rs35369693 with child aggression remained significant with sex and ethnicity as covariates (P = 0.007) or in Europeans-only analysis (ORC = 0.43; 95% CI: 0.21-0.9; P = 0.024).
“Results remained significant with sex and ethnicity as covariates (P = 0.007) or in Europeans-only analysis (ORC = 0.43; 95% CI: 0.21–0.9; P = 0.024).”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Zai [99]
The AVPR1B_rs35369693-rs2867650 C-A haplotype is under-represented in aggressive children (P-window=0.003; ORC-A = 0.28; 95% CI: 0.13-0.64; haplotype-specific P = 0.001).
“AVPR1B_rs35369693-rs2867650 C–A haplotype being under-represented in aggressive children (P-window=0.003; ORC-A = 0.28; 95% confidence interval: 0.13–0.64; haplotype-specific P = 0.001).”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Zai [99]
AVPR1B_rs35369693 C allele is less common in aggressive child cases than in healthy controls (ORC = 0.37, 95% CI: 0.17-0.77; P = 0.009).
“AVPR1B_rs35369693 C allele less common in the aggressive child cases than in the healthy controls (ORC = 0.37, 95% confidence interval: 0.17–0.77; P = 0.009).”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Zai [99]
The AVPR1B_rs28375468-rs35369693 G-C haplotype is underrepresented in aggressive children (P-window=0.038; ORG-C = 0.39; 95% CI: 0.18-0.84; haplotype-specific P = 0.013).
“AVPR1B_rs28375468-rs35369693 G-C haplotype underrepresented in aggressive children (P-window=0.038; ORG-C = 0.39; 95% CI: 0.18-0.84; haplotype-specific P = 0.013).”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Zai [99]
Two-marker haplotypes associated with AVPR1B_rs35369693 were nominally significant in European-only analysis, with the AVPR1B_rs35369693-rs28676508 C-A haplotype being under-represented in child cases (haplotype window P = 0.010; PC-A = 0.003).
“Two-marker haplotypes associated with AVPR1B_rs35369693 nominally significant in European-only analysis, with the AVPR1B_rs35369693-rs28676508 C–A haplotype being under-represented in child cases (haplotype window P = 0.010; PC–A = 0.003).”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Zai [99]
Markers in AVP and AVPR1A genes are not associated with child aggression.
“Markers in AVP and AVPR1A genes not associated with child aggression.”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Zai [99]
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Genetics of child aggression, a systematic review
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Self-citationVollebregt, O., Koyama, E., Zai, C. C., Shaikh, S. A., Lisoway, A. J., Kennedy, J. L., & Beitchman, J. H. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.05.062 · Cited by 13 · see citing works
Self-citation
- Authors
- Zai, C. C., Muir, K. E., Nowrouzi, B., Shaikh, S. A., Choi, E., Berall, L., Trépanier, M.-O., Beitchman, J. H., & Kennedy, J. L.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- ORCID
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 200
- Issue
- 2-3
- Pages
- 784-788
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2147618061
- Cited by
- 43
- References
- 6
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 6
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- CAMH Foundation (JHB, CCZ)
- Howitt/Dunbar Foundation and Youthdale Treatment Centres
- Canadian Institute for Health Research (JLK)
- American Foundation for Suicide Prevention (CCZ)
- Eli Lilly (CCZ)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- vasopressin, AVPR1B, child aggression, aggression, single nucleotide polymorphisms, haplotype association, genetic association, non-synonymous polymorphisms
- MeSH terms
- Adolescent, Aggression, Child, Female, Genotype, Haplotypes, Humans, Male, Receptors, Vasopressin, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genetic Association Studies
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