Distinct correlations of vasopressin release within the lateral septum and the bed nucleus of the stria terminalis with the display of intermale aggression
Abstract
Arginine vasopressin (AVP) has been implicated in a wide variety of social behaviors ranging from affiliation to aggression. However, the precise functional involvement of AVP in intermale aggression is still a matter of debate. In fact, very little is known about AVP release patterns within distinct brain regions during the display of intermale aggression and, in turn, the behavioral consequences of such release. We used intracerebral microdialysis to monitor local AVP release within the lateral septum (LS) and the bed nucleus of the stria terminalis (BST) of adult male Wistar rats during the resident-intruder (RI) test. Resident males were cohabitated with a female prior to the RI test to stimulate intermale aggression toward the intruder male. AVP release within the LS correlated positively with intermale aggression. The specific AVP V1a receptor antagonist d(CH(2))(5)Tyr(Me)AVP (10 microg/ml) administered via retrodialysis (3.3 microl/min, 30 min) into the LS of high-aggressive rats prior to the second RI test, prevented an increase in aggression in the second compared with the first RI test as seen in vehicle-treated high-aggressive rats. In contrast to the LS, AVP release within the BST correlated negatively with intermale aggression. Moreover, retrodialysis of synthetic AVP (1 microg/ml) administered into the BST of high-aggressive rats significantly reduced the display of aggression during the second RI test. These data reveal that AVP can both promote and inhibit intermale aggression, depending upon the brain region in which AVP is released. Although challenging the general view that central AVP release enhances intermale aggression in rodents, our data support a model in which AVP coordinates a range of social behaviors by eliciting region-specific effects.
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The 3-day recovery period was shown not to affect the display of social behavior.
“The 3-day recovery period matches that used for other procedures applied routinely in our lab (e.g., intracerebral microdialysis) and was shown not to affect the display of social behavior (Beiderbeck et al., 2007; Veenema et al., 2010, 2012; Lukas et al., 2011, 2013).”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Veenema et al., 2010
The injection site was chosen because it is positioned centrally in the region where males and females express high densities of V1aR and OTR binding in the lateral septum and corresponds with previous studies showing that pharmacological manipulations of AVP and OXT systems in the rat lateral septum altered social behavior.
“This injection site was chosen because it is positioned centrally in the region where males and females express high densities of V1aR and OTR binding in the lateral septum (Lukas et al., 2010; Veenema et al., 2012; Figure 1) and because the injection site corresponds with previous studies showing that pharmacological manipulations of AVP and OXT systems in the rat lateral septum altered social”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Veenema et al., 2010
AVP had a strong anxiogenic effect on elevated plus-maze behavior in juvenile males.
“yet it had a strong anxiogenic effect on elevated plus-maze behavior, confirming previous findings in adult male rats (Landgraf et al., 1995; Beiderbeck et al., 2007; Veenema et al., 2010).”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Veenema et al., 2010
Extracellular AVP release in the LS correlated positively with intermale aggression in testes intact rats.
“extracellular AVP release in the LS correlated positively with intermale aggression in testes intact rats (Veenema et al., 2010).”
From Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network (2017) · cites this paper as Veenema et al., 2010
Among rodents, the LS is a key regulator of social recognition and aggression and expresses high levels of AVP-ir.
“Among rodents, the LS is a key regulator of social recognition (Everts and Koolhaas, 1997; Lukas et al., 2013) and aggression (Veenema et al., 2010) and expresses high levels of AVP-ir”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Veenema et al., 2010
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586 · see citing works
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059 · see citing works
Self-citationGoodson, J. L., & Bass, A. H. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00043-1 · Cited by 632 · see citing works
Lim, M. M., Wang, Z., Olazábal, D. E., Ren, X., Terwilliger, E. F., & Young, L. J. (2004) · Nature · doi:10.1038/nature02539 · Cited by 628 · see citing works
de Vries, G. J., & Buijs, R. M. (1983) · Brain Research · doi:10.1016/0006-8993(83)90855-7 · Cited by 524 · cited 2× · see citing works
“The BST contains AVP-expressing neurons that send fibers to the LS (De Vries and Buijs, 1983; De Vries et al., 1984; van Leeuwen et al., 1985; Caffe et al., 1987).”
BackgroundFerris, C. F., Melloni Jr, R. H., Koppel, G., Perry, K. W., Fuller, R. W., & Delville, Y. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04331.1997 · Cited by 495 · see citing works
Young, L. J., Nilsen, R., Waymire, K. G., MacGregor, G. R., & Insel, T. R. (1999) · Nature · doi:10.1038/23475 · Cited by 488 · see citing works
Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis
Pow, D. V., & Morris, J. F. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90091-2 · Cited by 446 · see citing works
Tribollet, E., Barberis, C., Jard, S., Dubois-Dauphin, M., & Dreifuss, J. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)91437-0 · Cited by 442 · see citing works
Cerebrospinal Fluid Vasopressin Levels
Coccaro, E. F., Kavoussi, R. J., Hauger, R. L., Cooper, T. B., & Ferris, C. F. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.8.708 · Cited by 392 · see citing works
Young (1999) · doi:10.1038/23650 · Cited by 389 · see citing works
Bielsky, I. F., Hu, S.-B., Ren, X., Terwilliger, E. F., & Young, L. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.031 · Cited by 367 · see citing works
Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites
Ludwig, M., Sabatier, N., Bull, P. M., Landgraf, R., Dayanithi, G., & Leng, G. (2002) · Nature · doi:10.1038/nature00822 · Cited by 346 · see citing works
Landgraf, R., Gerstberger, R., Montkowski, A., Probst, J., Wotjak, C., Holsboer, F., & Engelmann, M. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-06-04250.1995 · Cited by 341 · see citing works
Central vasopressin and oxytocin release: regulation of complex social behaviours
VEENEMA, A., & NEUMANN, I. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00422-6 · Cited by 338 · see citing works
Self-citationNeumann, I., Russell, J. A., & Landgraf, R. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90285-n · Cited by 337 · see citing works
Self-citationDe Vries, G. J., Buds, R. M., & Swaab, D. F. (1981) · Brain Research · doi:10.1016/0006-8993(81)90989-6 · Cited by 319 · cited 1× · see citing works
“…system of the BST-LS circuit is sexually dimorphic in rats, with males having more AVP cells in the BST and denser AVP projections to the LS than females (De Vries et al., 1981; van Leeuwen et al., 1985), and these variables are strongly regulated by gonadal steroids (De Vries et al., 1983, 1994).”
BackgroundCaffé, A. R., van Leeuwen, F. W., & Luiten, P. G. M. (1987) · Journal of Comparative Neurology · doi:10.1002/cne.902610206 · Cited by 286 · see citing works
Ostrowski, N. L., Lolait, S. J., & Young, W. S. (1994) · Endocrinology · doi:10.1210/endo.135.4.7925112 · Cited by 284 · see citing works
Brain vasopressin is an important regulator of maternal behavior independent of dams’ trait anxiety
Bosch, O. J., & Neumann, I. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807412105 · Cited by 280 · see citing works
Self-citationEffects of early life stress on adult male aggression and hypothalamic vasopressin and serotonin.
Veenema, A. H., Blume, A., Niederle, D., Buwalda, B., & Neumann, I. D. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05045.x · Cited by 271 · see citing works
Self-citationVeenema, A. H., Bredewold, R., & Neumann, I. D. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.02.008 · Cited by 263 · see citing works
Self-citationCentrally released oxytocin mediates mating-induced anxiolysis in male rats
Waldherr, M., & Neumann, I. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705860104 · Cited by 261 · see citing works
Self-citationVasopressin receptor blockade in the anterior hypothalamus suppresses aggression in hamsters
Ferris, C. F., & Potegal, M. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90144-8 · Cited by 259 · see citing works
van Leeuwen, F. W., Caffe, A. R., & Vries, G. J. D. (1985) · Brain Research · doi:10.1016/0006-8993(85)90348-8 · Cited by 248 · see citing works
Social factors and individual vulnerability to chronic stress exposure
Bartolomucci, A., Palanza, P., Sacerdote, P., Panerai, A. E., Sgoifo, A., Dantzer, R., & Parmigiani, S. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.06.009 · Cited by 225 · see citing works
Engelmann, M., & Landgraf, R. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90022-1 · Cited by 225 · see citing works
Gonadal hormone actions on the morphology of the vasopressinergic innervation of the adult rat brain
De Vries, G. J., Buijs, R. M., & Sluiter, A. A. (1984) · Brain Research · doi:10.1016/0006-8993(84)91157-0 · Cited by 224 · see citing works
de Boer, S. F., van der Vegt, B. J., & Koolhaas, J. M. (2003) · Behavior Genetics · doi:10.1023/a:1025766415159 · Cited by 219 · cited 2× · see citing works
“…system in a single brain region might be insufficient to induce or enhance a highly complex behavior like aggression, especially in a rat strain that generally demonstrate low to moderate levels of intermale aggression as compared to other rat strains (De Boer et al., 2003; Veenema et al., 2007b).”
BackgroundGoodson, J. L. (1998) · Hormones and Behavior · doi:10.1006/hbeh.1998.1467 · Cited by 210 · see citing works
Goodson, J. L., & Kabelik, D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.007 · Cited by 204 · see citing works
De Vries, G., Wang, Z., Bullock, N., & Numan, S. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01789.1994 · Cited by 193 · cited 1× · see citing works
“…system of the BST-LS circuit is sexually dimorphic in rats, with males having more AVP cells in the BST and denser AVP projections to the LS than females (De Vries et al., 1981; van Leeuwen et al., 1985), and these variables are strongly regulated by gonadal steroids (De Vries et al., 1983, 1994).”
BackgroundLukas, M., Bredewold, R., Neumann, I. D., & Veenema, A. H. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.020 · Cited by 183 · see citing works
Self-citationGobrogge, K. L., Liu, Y., Young, L. J., & Wang, Z. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908620106 · Cited by 178 · see citing works
Septal vasopressin modulates anxiety-related behaviour in rats
Liebsch, G., Wotjak, C. T., Landgraf, R., & Engelmann, M. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)13069-x · Cited by 173 · see citing works
Goodson, & Adkins‐Regan (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00284.x · Cited by 171 · see citing works
Landgraf, R., Frank, E., Aldag, J. M., Neumann, I. D., Sharer, C. A., Ren, X., Terwilliger, E. F., Niwa, M., Wigger, A., & Young, L. J. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02750.x · Cited by 164 · see citing works
Self-citationBester‐Meredith, J. K., & Marler, C. A. (2001) · Hormones and Behavior · doi:10.1006/hbeh.2001.1666 · Cited by 163 · see citing works
Beiderbeck, D. I., Neumann, I. D., & Veenema, A. H. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05974.x · Cited by 142 · see citing works
Self-citationVries, G. J. D., Best, W., & Sluiter, A. A. (1983) · Developmental Brain Research · doi:10.1016/0165-3806(83)90019-6 · Cited by 141 · see citing works
Wang, Z., Smith, W., Major, D. E., & Vries, G. J. D. (1994) · Brain Research · doi:10.1016/0006-8993(94)91784-1 · Cited by 141 · see citing works
Interleukin‐1β Stimulates both Central and Peripheral Release of Vasopressin and Oxytocin in the Rat
Landgraf, R., Neumann, I. D., Holsboer, F., & Pittman, Q. J. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00663.x · Cited by 136 · see citing works
Self-citationGoodson, J. L. (1998) · General and Comparative Endocrinology · doi:10.1006/gcen.1998.7112 · Cited by 135 · see citing works
Differential lateral septal vasopressin innervation in aggressive and nonaggressive male mice
Compaan, J. C., Buijs, R. M., Pool, C. W., De Ruiter, A. J. H., & koolhaas, J. M. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90032-7 · Cited by 135 · see citing works
Ebner, K., Wotjak, C. T., Landgraf, R., & Engelmann, M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02464-1 · Cited by 129 · see citing works
Frazier, C. R. M., Trainor, B. C., Cravens, C. J., Whitney, T. K., & Marler, C. A. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.035 · Cited by 121 · see citing works
Ostrowski, N. L., Lolait, S. J., & Young, W. S. (1994) · Endocrinology · doi:10.1210/en.135.4.1511 · Cited by 119 · see citing works
Goodson, J. L., Lindberg, L., & Johnson, P. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2003.08.006 · Cited by 115 · see citing works
Orally active vasopressin V1a receptor antagonist, SRX251, selectively blocks aggressive behavior
Ferris, C. F., Lu, S., Messenger, T. L., Guillon, C. D., Heindel, N. D., Miller, M., KOPPEL, G. A., Bruns, F., & Simon, N. G. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.01.001 · Cited by 111 · see citing works
Vasopressin in the septal area of the golden hamster controls scent marking and grooming
Irvin, R. W., Szot, P., Dorsa, D. M., Potegal, M., & Ferris, C. F. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90213-n · Cited by 105 · see citing works
Differential Lateral Septal Vasopressin in Wild-type Rats: Correlation with Aggression
Everts, H. G. J., de Ruiter, A. J. H., & Koolhaas, J. M. (1997) · Hormones and Behavior · doi:10.1006/hbeh.1997.1375 · Cited by 102 · see citing works
Veenema, A. H., Torner, L., Blume, A., Beiderbeck, D. I., & Neumann, I. D. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.07.004 · Cited by 102 · see citing works
Self-citationKoolhaas, J. M., Everts, H., de Ruiter, A. J. H., de Boer, S. F., & Bohus, B. (1999) · Progress in Brain Research · doi:10.1016/s0079-6123(08)61586-1 · Cited by 100 · see citing works
Behavioural impact of intraseptally released vasopressin and oxytocin in rats
Englemann, M., Wotjak, C. T., Ebner, K., & Landgraf, R. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.tb00015.x · Cited by 94 · see citing works
Arginine–vasotocin influence on aggressive behavior and dominance in rainbow trout
Bäckström, T., & Winberg, S. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.11.013 · Cited by 79 · see citing works
Agonistic behavior: A model, experimental studies, and perspectives
Kudryavtseva, N. N. (2000) · Neuroscience and Behavioral Physiology · doi:10.1007/bf02471782 · Cited by 69 · see citing works
Release of vasopressin within the brain contributes to neuroendocrine and behavioral regulation
Landgraf, R., Wotjak, C. T., Neumann, I. D., & Engelmann, M. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61571-x · Cited by 66 · see citing works
Self-citationEngelmann, M., Ludwig, M., & Landgraf, R. (1992) · Behavioral and Neural Biology · doi:10.1016/0163-1047(92)90907-l · Cited by 64 · see citing works
Bester‐Meredith, J. K., MARTIN, P. A., & Marler, C. A. (2005) · Aggressive Behavior · doi:10.1002/ab.20075 · Cited by 57 · see citing works
Jackson, D., Burns, R., Trksak, G. H., Simeone, B. P., DeLeon, K. R., Connor, D. F., Harrison, R. J., & Melloni, R. H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.02.047 · Cited by 34 · see citing works
Delville, Y., Vries, G. J. D., Schwartz, W. J., & Ferris, C. F. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.6.1486 · Cited by 24 · see citing works
Delville, Y., Vries, G. J. D., Schwartz, W. J., et al. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.6.1486 · Cited by 20 · see citing works
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Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Self-citationNeumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954 · see citing works
Self-citationDumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520 · see citing works
“Local VP release in the brain has been measured in male (Veenema et al., 2010; Lukas et al., 2011a) and female (Bosch & Neumann, 2010; Bosch et al.”
BackgroundSelf-citationNeuromodulation by Oxytocin and Vasopressin
Stoop, R. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.025 · Cited by 506 · see citing works
Bos, P. A., Panksepp, J., Bluthé, R.-M., & Honk, J. V. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.01.002 · Cited by 429 · see citing works
Lukas, M., Toth, I., Reber, S. O., Slattery, D. A., Veenema, A. H., & Neumann, I. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.95 · Cited by 403 · see citing works
Self-citationBosch, O. J., & Neumann, I. D. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.11.002 · Cited by 400 · see citing works
Self-citationNonapeptide mechanisms of social cognition, behavior and species-specific social systems
Goodson, J. L., & Thompson, R. R. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.08.020 · Cited by 261 · see citing works
Aggression and anxiety: social context and neurobiological links
Neumann, I. D. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00012 · Cited by 238 · see citing works
Self-citationPerrone, R., & da Silva, A. C. R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00001 · Cited by 210 · see citing works
Maternal aggression in rodents: brain oxytocin and vasopressin mediate pup defence
Bosch, O. J. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0085 · Cited by 194 · see citing works
Sex-specific modulation of juvenile social play by vasopressin
Veenema, A. H., Bredewold, R., & De Vries, G. J. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.002 · Cited by 166 · see citing works
“Importantly, we do not find effects of surgery and cannula or probe implantation after two days on behavior in various behavioral tests (Beiderbeck et al., 2007; Veenema et al., 2010, 2012; Lukas et al., 2011, 2013).”
BackgroundSelf-citationBredewold, R., Smith, C. J. W., Dumais, K. M., & Veenema, A. H. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00216 · Cited by 157 · see citing works
Self-citationVeenema, A. H. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.002 · Cited by 157 · see citing works
Self-citationToth, M., Mikics, E., Tulogdi, A., Aliczki, M., & Haller, J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.02.003 · Cited by 152 · see citing works
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Menon, R., Süß, T., Oliveira, V. E. D. M., Neumann, I. D., & Bludau, A. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.10.010 · Cited by 158 · see citing works
Self-citationKelly, A. M., & Goodson, J. L. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.04.005 · Cited by 141 · see citing works
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Self-citationVeenema, A. H., Bredewold, R., & De Vries, G. J. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.10.002 · Cited by 129 · see citing works
Self-citationOliveira, V. E. D. M., Lukas, M., Wolf, H. N., Durante, E., Lorenz, A., Mayer, A.-L., Bludau, A., Bosch, O. J., Grinevich, V., Egger, V., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23064-5 · Cited by 126 · see citing works
Self-citationLukas, M., Bredewold, R., Landgraf, R., Neumann, I. D., & Veenema, A. H. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.11.007 · Cited by 122 · see citing works
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Self-citationChildhood aggression, callous-unemotional traits and oxytocin genes
Beitchman, J. H., Zai, C. C. H., Muir, K. E., Berall, L. E., Nowrouzi‐Kia, B., Choi, E., & Kennedy, J. L. (2012) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-012-0240-6 · Cited by 103 · see citing works
Cataldo, I., Azhari, A., & Esposito, G. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00027 · Cited by 95 · see citing works
Kokras, N., Hodes, G. E., Bangasser, D. A., & Dalla, C. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14710 · Cited by 94 · see citing works
Murakami, G., Hunter, R. G., Fontaine, C., Ribeiro, A., & Pfaff, D. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07761.x · Cited by 99 · see citing works
Kleszczyńska, A., Sokołowska, E., & Kulczykowska, E. (2011) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2011.11.022 · Cited by 89 · see citing works
Oliveira, V. E. D. M., Neumann, I. D., & de Jong, T. R. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.01.019 · Cited by 87 · see citing works
Self-citationMayer, U., Salva, O. R., & Vallortígara, G. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.09.031 · Cited by 80 · see citing works
Zhang, H.-F., Dai, Y., Wu, J., Jia, M., Zhang, J., Shou, X., Han, S., Zhang, R., & Han, J. (2016) · Neuroscience Bulletin · doi:10.1007/s12264-016-0046-5 · Cited by 87 · see citing works
Calcagnoli, F., de Boer, S. F., Beiderbeck, D. I., Althaus, M., Koolhaas, J. M., & Neumann, I. D. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.050 · Cited by 84 · see citing works
Self-citationDiBenedictis, B. T., Nussbaum, E. R., Cheung, H. K., & Veenema, A. H. (2017) · Journal of Comparative Neurology · doi:10.1002/cne.24216 · Cited by 74 · see citing works
“, 1991) and extracellular AVP release in the LS correlated positively with intermale aggression in testes intact rats (Veenema et al., 2010).”
BackgroundSelf-citationA, T. R. D. J., & Neumann, I. D. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_13 · Cited by 74 · see citing works
Self-citationHicks, C., Jorgensen, W., Brown, C., Fardell, J., Koehbach, J., Gruber, C. W., Kassiou, M., Hunt, G. E., & McGregor, I. S. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02311.x · Cited by 73 · see citing works
Steinman, M. Q., Laredo, S. A., Lopez, E. M., Manning, C. E., Hao, R. C., Doig, I. E., Campi, K. L., Flowers, A. E., Knight, J. K., & Trainor, B. C. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.009 · Cited by 73 · see citing works
Coordination of social behaviors by the bed nucleus of the stria terminalis
Flanigan, M. E., & Kash, T. L. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.14991 · Cited by 71 · see citing works
The neurobiology of offensive aggression: Revealing a modular view
de Boer, S. F., Olivier, B., Veening, J., & Koolhaas, J. M. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.04.040 · Cited by 70 · see citing works
Neuropeptide diversity and the regulation of social behavior in New World primates
French, J. A., Taylor, J. H., Mustoe, A. C., & Cavanaugh, J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.03.004 · Cited by 66 · see citing works
Rigney, N., Whylings, J., Mieda, M., de Vries, G. J., & Petrulis, A. (2019) · eNeuro · doi:10.1523/eneuro.0415-18.2019 · Cited by 63 · see citing works
“In rats, where AVP release in the septum, one of the most prominent projection areas of BNST and MeA AVP cells (De Vries and Buijs, 1983; De Vries and Panzica, 2006), correlates positively with intermale aggression in a resident-intruder test, a behavioral response could be blocked by retro-dialysis of an AVP antagoni…”
BackgroundInfluentialCalandreau, L., Márquez, C., Bisaz, R., Fantin, M., & Sandi, C. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00635.x · Cited by 61 · see citing works
Modulation of social behavior by distinct vasopressin sources
Rigney, N., Vries, G. J. D., & Petrulis, A. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1127792 · Cited by 61 · see citing works
Smith, C. J. W., DiBenedictis, B. T., & Veenema, A. H. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.02.001 · Cited by 59 · see citing works
Self-citationWang, Y., He, Z., Zhao, C., & Li, L. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.002 · Cited by 59 · see citing works
Ross, A. P., McCann, K. E., Larkin, T. E., Song, Z., Grieb, Z. A., Huhman, K. L., & Albers, H. E. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.104578 · Cited by 57 · see citing works
Oxytocin and vasopressin inhibit hyper-aggressive behaviour in socially isolated mice
Tan, O., Musullulu, H., Raymond, J. S., Wilson, B. B., Langguth, M., & Bowen, M. T. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.016 · Cited by 56 · see citing works
Dhakar, M. B., Rich, M. E., Reno, E. L., Lee, H.-J., & Caldwell, H. K. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.05.007 · Cited by 54 · see citing works
Kompier, N. F., Keysers, C., Gazzola, V., Lucassen, P. J., & Krugers, H. J. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00143 · Cited by 53 · see citing works
Duque‐Wilckens, N., Steinman, M. Q., Laredo, S. A., Hao, R., Perkeybile, A. M., Bales, K. L., & Trainor, B. C. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.018 · Cited by 52 · see citing works
The Role of Serotonin, Vasopressin, and Serotonin/Vasopressin Interactions in Aggressive Behavior
Morrison, T. R., & Melloni, R. H. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_283 · Cited by 51 · see citing works
Lee, W., Hiura, L. C., Yang, E., Denney, K. A., Ophir, A. G., & Curley, J. P. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.06.015 · Cited by 46 · see citing works
Endogenous Oxytocin, Vasopressin, and Aggression in Domestic Dogs
MacLean, E. L., Gesquiere, L. R., Gruen, M. E., Sherman, B. L., Martin, W. L., & Carter, C. S. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01613 · Cited by 49 · see citing works
Dewan, A., & Tricas, T. C. (2011) · Brain Research · doi:10.1016/j.brainres.2011.05.029 · Cited by 48 · see citing works
Neuropeptide Regulation of Social Attachment: The Prairie Vole Model
Tabbaa, M., Paedae, B., Liu, Y., & Wang, Z. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150055 · Cited by 53 · see citing works
Long-term programming of enhanced aggression by peripuberty stress in female rats
Cordero, M. I., Ansermet, F., & Sandi, C. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.07.005 · Cited by 45 · see citing works
Septal oxytocin administration impairs peer affiliation via V1a receptors in female meadow voles
Anacker, A. M. J., Christensen, J. D., LaFlamme, E. M., Grunberg, D. M., & Beery, A. K. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.02.025 · Cited by 44 · see citing works
Dewan, A., Ramey, M. L., & Tricas, T. C. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.10.002 · Cited by 44 · see citing works
Possible genetic association between vasopressin receptor 1B and child aggression
Zai, C. C., Muir, K. E., Nowrouzi, B., Shaikh, S. A., Choi, E., Berall, L., Trépanier, M.-O., Beitchman, J. H., & Kennedy, J. L. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.07.031 · Cited by 43 · see citing works
Rigney, N., Whylings, J., de Vries, G. J., & Petrulis, A. (2021) · Neuroendocrinology · doi:10.1159/000509421 · Cited by 42 · see citing works
Olucha-Bordonau, F. E., Fortes-Marco, L., Otero‐García, M., Lanuza, E., & Martínez‐Garciá, F. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-374245-2.00018-8 · Cited by 42 · see citing works
Qiao, X., Yan, Y., Wu, R., Tai, F., Hao, P., Cao, Y., & Wang, J. (2014) · Journal of Comparative Physiology A · doi:10.1007/s00359-013-0870-2 · Cited by 40 · see citing works
Animal models of social stress: the dark side of social interactions
Masís-Calvo, M., Schmidtner, A. K., Oliveira, V. E. D. M., Grossmann, C. P., A, T. R. D. J., & Neumann, I. D. (2018) · Stress · doi:10.1080/10253890.2018.1462327 · Cited by 41 · see citing works
Self-citationAggression- and sex-induced neural activity across vasotocin populations in the brown anole
Kabelik, D., Alix, V. C., Burford, E. R., & Singh, L. J. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.11.016 · Cited by 38 · see citing works
Neural mechanisms of female sexual behavior in the rat; comparison with male ejaculatory control
Veening, J. G., Coolen, L. M., & Gerrits, P. O. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.025 · Cited by 38 · see citing works
The role of vasopressin in olfactory and visual processing
Wacker, D. W., & Ludwig, M. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2867-1 · Cited by 36 · see citing works
Csoltova, E., & Mehinagic, E. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.02131 · Cited by 35 · see citing works
Choi, J.-Y., Park, M.-N., Kim, C.-S., Lee, Y.-K., Choi, E. Y., Chun, W. Y., & Shin, D.-M. (2017) · Scientific Reports · doi:10.1038/srep45693 · Cited by 32 · see citing works
A Teleost Fish Model to Understand Hormonal Mechanisms of Non-breeding Territorial Behavior
da Silva, A. C. R., Zubizarreta, L., & Quintana, L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00468 · Cited by 30 · see citing works
Rigney, N., Zbib, A., de Vries, G. J., & Petrulis, A. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13083 · Cited by 29 · see citing works
Conspecific Interactions in Adult Laboratory Rodents: Friends or Foes?
Lukas, M., & A, T. R. D. J. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_428 · Cited by 29 · see citing works
Self-citationAggression: Perspectives from social and systems neuroscience
Kelly, A. M., & Wilson, L. C. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.04.010 · Cited by 27 · see citing works
Wang, L., Simms, J. A., Peters, C. J., Fontaine, M. T.-L., Li, K., Gill, T. M., Jan, Y. N., & Jan, L. Y. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.3137-18.2019 · Cited by 29 · see citing works
Social Status and Arginine Vasotocin Neuronal Phenotypes in a Cichlid Fish
Almeida, O., & Oliveira, R. F. (2015) · Brain Behavior and Evolution · doi:10.1159/000381251 · Cited by 28 · see citing works
The effects of vasopressin deficiency on aggression and impulsiveness in male and female rats
Fodor, A., Barsvári, B., Aliczki, M., Balogh, Z., Zelena, D., Goldberg, S. R., & Haller, J. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.05.010 · Cited by 28 · see citing works
Oldfield, R. G., Harris, R. M., & Hofmann, H. A. (2015) · Frontiers in Zoology · doi:10.1186/1742-9994-12-s1-s16 · Cited by 27 · see citing works
Holman, P. J., Ellis, L. A., Morgan, E., & Weinberg, J. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.08.004 · Cited by 26 · see citing works
Genetics of Aggression in Voles
Gobrogge, K. L., & Wang, Z. (2011) · Advances in genetics · doi:10.1016/b978-0-12-380858-5.00003-4 · Cited by 26 · see citing works
Rigney, N., Campos‐Lira, E., Kirchner, M. K., Wei, W., Belkasim, S., Beaumont, R., Singh, S. P., Suarez, S. G., Hartswick, D., Stern, J. E., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2319641121 · Cited by 23 · see citing works
Wacker, D. W., Khalaj, S., Jones, L. A., Champion, T., Davis, J. E., Meddle, S. L., & Wingfield, J. C. (2016) · Journal of neuroendocrinology · doi:10.1111/jne.12443 · Cited by 25 · see citing works
Weger, M., Sevelinges, Y., Grosse, J., de Suduiraut, I. G., Zanoletti, O., & Sandi, C. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.01.008 · Cited by 24 · see citing works
Neuroendocrine regulation of female aggression
Oliveira, V. E. D. M., & Bakker, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.957114 · Cited by 22 · see citing works
Zhao, C., Saul, M. C., Driessen, T. M., & Gammie, S. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038602 · Cited by 22 · see citing works
DiBenedictis, B. T., Cheung, H. K., Nussbaum, E. R., & Veenema, A. H. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104462 · Cited by 20 · see citing works
Self-citationAndrogen receptor deficiency alters the arginine-vasopressin sexually dimorphic system in Tfm rats
Allieri, F., Spigolon, G., Melcangi, R. C., Collado, P., Guillamón, A., Gotti, S., & Panzica, G. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.036 · Cited by 20 · see citing works
Li, H., Sung, H. H., & Lau, C. G. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102253 · Cited by 18 · see citing works
Fokidis, H. B., & Deviche, P. (2011) · Brain, Behavior and Evolution · doi:10.1159/000332766 · Cited by 20 · see citing works
Kelly, A. M., Saunders, A. G., & Ophir, A. G. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.01.006 · Cited by 18 · see citing works
Sex, Drugs, and Violence: Neuromodulation of Attachment and Conflict in Voles
Gobrogge, K. L. (2013) · Current topics in behavioral neurosciences · doi:10.1007/7854_2013_264 · Cited by 16 · see citing works
Rujeedawa, T., & Zaman, S. H. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031315 · Cited by 19 · see citing works
Sailer, L. L., Park, A. H., Galvez, A., & Ophir, A. G. (2022) · Communications Biology · doi:10.1038/s42003-022-04274-z · Cited by 15 · see citing works
Effects of alcohol and psychostimulants on the vasopressin system: Behavioural implications
Godino, A., & Renard, G. M. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12611 · Cited by 17 · see citing works
Værøy, H., Schneider, F., & Fetissov, S. O. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00872 · Cited by 16 · see citing works
Basic emotional foundations of social dominance in relation to Panksepp's affective taxonomy
van der Westhuizen, D., & Solms, M. (2015) · Neuropsychoanalysis · doi:10.1080/15294145.2015.1021371 · Cited by 17 · see citing works
He, F., Tai, F.-D., Zhang, Y.-H., & Zhang, X. (2012) · Journal of Comparative Physiology · doi:10.1007/s00359-012-0713-6 · Cited by 16 · see citing works
- Authors
- Veenema, A. H., Beiderbeck, D. I., Lukas, M., & Neumann, I. D.
- Affiliations
- University of Regensburg (DE)
- Corresponding author
- Veenema, Alexa H.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 58
- Issue
- 2
- Pages
- 273-281
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2168681457
- Cited by
- 180
- References
- 61
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 14 · 2022: 32 · 2021: 8 · 2020: 5 · 2019: 12 · 2018: 10 · 2017: 9 · 2016: 15 · 2015: 15 · 2014: 8 · 2013: 12 · 2012: 13
- FWCI
- 19.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- vasopressin, male-male aggression, lateral septum, bed nucleus of the stria terminalis, resident-intruder test, V1a receptor antagonist, social behavior, retrodialysis
- MeSH terms
- Aggression, Animals, Arginine Vasopressin, Female, Hormone Antagonists, Housing, Animal, Male, Psychological Tests, Septal Nuclei, Social Behavior, Territoriality, Time Factors, Rats, Wistar, Receptors, Vasopressin, Rats, Antidiuretic Hormone Receptor Antagonists
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