Increase of circulating BDNF levels and its relation to improvement of physical fitness following 12 weeks of combined exercise in chronic patients with schizophrenia: A pilot study
Abstract
Brain-derived neurotrophic factor (BDNF), the most abundant of neurotrophins in the brain, is known to be responsible for maintenance of neurons has been implicated in the pathology of schizophrenia. In the present pilot study, we investigated the effect of a combined exercise program on circulating BDNF expression and the relationship between BDNF and improvements in physical fitness. Twenty-four patients with schizophrenia participated in the exercise intervention, three nonconsecutive days per week for 12 weeks. The resistance exercise program used the elastic band for eight different exercises for 25 min, and the aerobic exercise consisted of moderate walking for 25 min. After the training program, there were positive improvements in body composition and blood pressure. Also, there was significant improvement in leg strength, cardiovascular fitness, balance, and jump. Serum BDNF values had significantly increased following the combined exercise program. The elevation in serum BDNF concentrations correlated significantly with improvements in cardiovascular fitness and leg strength. These results suggest that exercise induced modulation of BDNF may play an important role in developing non-pharmacological treatment for chronic schizophrenic patients. In addition, these preliminary results serve to generate further hypothesis and facilitate the planning the exercise training program and management of participants.
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Physical activity augments neuronal protection in brain disorders by stimulating BDNF expression.
“These studies indeed indicated that physical activity augments neuronal protection in brain disorders by stimulating BDNF expression.”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [212]
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- Authors
- Kim, H.-J., Song, B.-K., So, B., Lee, O., Song, W., & Kim, Y.
- Affiliations
- Seoul National University (KR)
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 220
- Issue
- 3
- Pages
- 792-796
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2067133371
- Cited by
- 69
- References
- 40
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 9 · 2016: 9 · 2015: 7
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- brain-derived neurotrophic factor, schizophrenia, concurrent training, resistance training, aerobic exercise, physical fitness, cardiorespiratory fitness, leg strength, non-pharmacological treatment, chronic psychiatric patients, serum BDNF
- MeSH terms
- Adult, Chronic Disease, Cross-Sectional Studies, Exercise Therapy, Female, Humans, Male, Middle Aged, Physical Fitness, Pilot Projects, Schizophrenia, Exercise, Brain-Derived Neurotrophic Factor
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