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Factors associated with depression, anxiety, and PTSD symptomatology during the COVID-19 pandemic: Clinical implications for U.S. young adult mental health
Open accessAbstract
This study sought to identify factors associated with depression, anxiety, and PTSD symptomatology in U.S. young adults (18-30 years) during the COVID-19 pandemic. This cross-sectional online study assessed 898 participants from April 13, 2020 to May 19, 2020, approximately one month after the U.S. declared a state of emergency due to COVID-19 and prior to the initial lifting of restrictions across 50 U.S. states. Respondents reported high levels of depression (43.3%, PHQ-8 scores ≥ 10), high anxiety scores (45.4%, GAD-7 scores ≥ 10), and high levels of PTSD symptoms (31.8%, PCL-C scores ≥ 45). High levels of loneliness, high levels of COVID-19-specific worry, and low distress tolerance were significantly associated with clinical levels of depression, anxiety, and PTSD symptoms. Resilience was associated with low levels of depression and anxiety symptoms but not PTSD. Most respondents had high levels of social support; social support from family, but not from partner or peers, was associated with low levels of depression and PTSD. Compared to Whites, Asian Americans were less likely to report high levels across mental health symptoms, and Hispanic/Latinos were less likely to report high levels of anxiety. These factors provide initial guidance regarding the clinical management for COVID-19-related mental health problems.
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“On the other hand, exposure to nature may regulate stress, thus enhancing tolerance to negative emotions (34, 35), which may further reduce the risk of depression and anxiety (36, 37).”
From Can Viewing Nature Through Windows Improve Isolated Living? A Pathway Analysis on Chinese Male Prisoners During the COVID-19 Epidemic (2021) · cites this paper as [36]
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“Socially restrictive measures, quarantines and lockdowns have been associated with reduced social interaction and increased loneliness that may lead to a rise in mental health problems such as symptoms of depression and anxiety.”
From A Longitudinal Study of Loneliness Before the End of the COVID-19 Pandemic: Trajectories, Predictors, and Impact on Chinese Adolescent Mental Health (2024) · cites this paper as [6]
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“this is a lower prevalence when compared to those reported by research carried out on young adult populations at the early stages of the pandemic when social isolation was imposed to limit the spread of the virus (Faisal et al., 2022; Liu et al., 2020; Varma et al., 2021).”
From Social connections combat loneliness and promote wellbeing among college students coming out of the COVID-19 pandemic (2025) · cites this paper as Liu et al., 2020
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Gracia, D. R., & Rubetta, E. R. (2020) · JURNAL KESEHATAN LINGKUNGAN · doi:10.20473/jkl.v12i1si.2020.29-37 · Cited by 8
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Strizhitskaya, O. Y., Petrash, M. D., Ралифовна, М. И., Vartanyan, G., & Shchukin, A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18189889 · Cited by 8
Radyani, A. M., Indra, G. H., & Oriza, I. I. D. (2022) · KnE Social Sciences · doi:10.18502/kss.v7i1.10210 · Cited by 7
“Feeling disengaged from social connection due to social distancing and isolation may make one feel lonely and vulnerable, especially among college students [27], [6], [28], [29].”
BackgroundInfluentialUng, M., Wan, K. Y. Y., Liu, S. Y., Choo, Y. J., Liew, N. S. W., Shang, Z. A., Khoo, S. S. H., Tay, W. X., Lin, R., & Yi, S. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095636 · Cited by 6
“In the United States, loneliness was significantly associated with clinical anxiety levels among young adults [51] and the general population [52].”
BackgroundAyhan, F., Balsak, H., & Ayhan, V. (2022) · The International Journal of Health Planning and Management · doi:10.1002/hpm.3528 · Cited by 6
Social support against depression in young adults’ group during COVID-19 pandemic
Gawrych, M., Cichoń, E., & Kiejna, A. (2022) · Psychiatria Polska · doi:10.12740/pp/onlinefirst/147433 · Cited by 8
“An important role in mental health outcomes is attributed to such factors as: loneliness, personal coping strategies, resilience, dis - tress tolerance, and family support [4, 6–10].”
Vally, Z., & Helmy, M. S. (2022) · PLoS ONE · doi:10.1371/journal.pone.0271332 · Cited by 7
Olumekor, M. O., Stojić, A., Kehler, T., & Polo, F. (2022) · Behavioral Sciences · doi:10.3390/bs12110463 · Cited by 7
“[39], older adults tend to have “better emotional regulation and well-being than younger adults”.”
BackgroundMental health issues assessment using tools during COVID-19 pandemic
Rao, H., Gupta, M., Agarwal, P., Bhatia, S., & Bhardwaj, R. (2022) · Innovations in Systems and Software Engineering · doi:10.1007/s11334-022-00510-1 · Cited by 7
Bringing Covid to College: Incoming First-Year College Students’ Making Meaning of the Pandemic
Vélez, G., Hoekstra, E., Nemanich, S. T., Jessup‐Anger, J. E., & Herteen, M. (2023) · Emerging Adulthood · doi:10.1177/21676968231163914 · Cited by 10
Pandemic-related life changes and adolescent initiation of cannabis and tobacco/nicotine use
Herzig, S. E., Albers, L. D., Soto, D. W., Lee, R. C., Ramirez, C., Rahman, T. M., & Unger, J. B. (2023) · Addictive Behaviors · doi:10.1016/j.addbeh.2023.107724 · Cited by 8
“…depression, and substance use (including cannabis and tobacco/nicotine use) among adults and adolescents (Berki & Pikó, 2021; Chaiton, Dubray, Kundu, & Schwartz, 2022; Liu et al., 2020; Papp & Kouros, 2021; Villanti et al., 2022; Czeisler et al., 2020; Rogers, Shepherd, Garey, & Zvolensky, 2020).”
Chiang, W.-C., & Chen, S. (2023) · Current Psychology · doi:10.1007/s12144-023-04643-9 · Cited by 8
Pandemic stressors and mental health indicators in eight countries
Abdalla, S. M., Koya, S. F., Rosenberg, S. B., Stovall, I. B., Biermann, O., Zeinali, Z., Cohen, G. H., Ettman, C. K., & Galea, S. (2023) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-023-02541-w · Cited by 8
Chery, M. J., Baral, A., Rolle, L. D., Abdshah, A., Bernard, M., Poudel, L., Francois, L., Jones, D. L., Jean‐Louis, G., & Blanc, J. (2024) · Nature and Science of Sleep · doi:10.2147/nss.s434148 · Cited by 7
Exploring the Impact of COVID-19 Hoax on the Mental Health of Millennial Moms
Dharmastuti, A., Apriliyanti, F., & Wahyuni, F. (2021) · KnE Social Sciences · doi:10.18502/kss.v4i15.8230 · Cited by 8
Modern foreign studies of depressive disorders during the COVID-19 pandemic
Khramov, E. V., & Ivanov, V. S. (2021) · Journal of Modern Foreign Psychology · doi:10.17759/jmfp.2021100104 · Cited by 7
Shpakou, A., Klimatckaia, L. G., Skoblina, N., Baj–Korpak, J., Skarbalienė, A., Fedortsiv, O., Krestyaninova, T. Y., Znatnova, A. V., Kuzniatsou, A., & Cherkasova, J. (2021) · Психология Журнал Высшей школы экономики · doi:10.17323/1813-8918-2021-4-871-887 · Cited by 7
Carmassi, C., Cordone, A., Bertelloni, C., Cappelli, A., Pedrinelli, V., Sampogna, G., Massimetti, G., Dell'Oste, V., & Dell'Osso, L. (2022) · European psychiatry · doi:10.1192/j.eurpsy.2021.2247 · Cited by 6
“Female gender represents a risk factor for acute psychopathological reaction to traumatic events [64], as confirmed by recent studies conducted in the frame of COVID-19 pandemic [65][66].”
ResultSleep quality and mental health during COVID-19: the role of distress tolerance.
Leonelli, B. R., Kuhn, T., & Hughes, J. W. (2023) · Psychology, Health & Medicine · doi:10.1080/13548506.2022.2083644 · Cited by 6
“Sleep quality is associated with distress tolerance (Reitzel et al., 2017; Short et al., 2016), which predicted depressive and anxiety symptoms during the COVID-19 pandemic (Liu et al., 2020).”
BackgroundEvidence of higher suicidal ideation among young adults in Canada during the COVID-19 pandemic
Dubé, G., Legault, R., Dorfman, A., Stolle, D., Pelletier‐Dumas, M., de la Sablonnière, R., & Lacourse, É. (2024) · Scientific Reports · doi:10.1038/s41598-024-68823-8 · Cited by 6
Cook, J. Α., Jonikas, J. A., Burke-Miller, J. K., Aranda, F., Mullen, M. G., Davis, M., & Sabella, K. A. (2025) · The Journal of Behavioral Health Services & Research · doi:10.1007/s11414-024-09924-0 · Cited by 7
Are you stressed or just excited? What the Garmin Stress Score can say about your mood
van der Mee, D. J., Koyuncu, Z., & Lemmers-Jansen, I. L. J. (2025) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2025.100974 · Cited by 8
Erfidan, G., Özyurt, G., Çamlar, S. A., Şimşek, Ö. Ö., Başaran, C., Alaygut, D., Mutlubaş, F., & Demir, B. K. (2021) · Pediatrics International · doi:10.1111/ped.14887 · Cited by 6
“All rights reserved GAD 5 (1-14) ns 8 (1-12) ns ns”
BackgroundRogier, G., Zobel, S., Rizzi, D., & Velotti, P. (2022) · Psychiatry Investigation · doi:10.30773/pi.2022.0013 · Cited by 5
Assessment of burnout level among clinical dental students during the COVID-19 pandemic
Korkmaz, C., Dikicier, S., & Atay, A. (2023) · BMC Medical Education · doi:10.1186/s12909-023-04729-9 · Cited by 6
“Liu et al. [42] stated that high perceived social support from family was associated with lower levels of depression and post-traumatic stress disorder.”
BackgroundModeling emotional contagion in the COVID-19 pandemic: a complex network approach
Zhu, Y., Zhang, W., & Li, C. (2023) · PeerJ Computer Science · doi:10.7717/peerj-cs.1693 · Cited by 6
“With the onset of the COVID-19 pandemic, stress has been identified as a profound threat to public health, predisposing individuals to an array of negative emotional responses and thereby facilitating the development of mental health conditions such as depression and anxiety ( Liu et al., 2020 ).”
BackgroundEstacio, R. D., Subida, M. D., Bagaforo, M. V., Abuyuan, M. C., Dionisio, N. Y., & Letso, S. C. (2023) · Asia Pacific Journal of Counselling and Psychotherapy · doi:10.1080/21507686.2023.2281430 · Cited by 6
“In the studies conducted by Munir (2022), Jungmin Lee et al. (2021), Wang et al. (2021), Lail et al. (2021), Esterwood and Saeed (2020), Islam et al. (2020), and Liu et al. (2020), the mental health of college learners has been examined.”
BackgroundGhaffar, K., Munir, R., Younas, F., Muneer, A., Sardar, M. F., Albasher, G. I., & Noreen, S. (2024) · Journal of Dispersion Science and Technology · doi:10.1080/01932691.2024.2325388 · Cited by 6
Ganai, U. J., Sachdev, S., & Bhushan, B. (2024) · British Journal of Clinical Psychology · doi:10.1111/bjc.12487 · Cited by 7
Morabito, D. M., Bedford, C. E., Woller, S. J., & Schmidt, N. B. (2021) · Journal of Traumatic Stress · doi:10.1002/jts.22717 · Cited by 6
“…current research demonstrating the impact of the COVID–19 pandemic on mental health difficulties (e.g., Fitzpatrick et al., 2020; Lebel et al., 2020; Liu et al., 2020; Tang et al., 2020; Twenge & Joiner, 2020) as well as with findings from prior studies illustrating the association between…”
BackgroundResultSilverman, J. R., & Wang, B. Z. (2021) · Nutrients · doi:10.3390/nu13082723 · Cited by 7
KESEHATAN MENTAL PADA PENYINTAS COVID-19: A LITERATURE REVIEW
Wulan, N. L. N., & Keliat, B. A. (2021) · Jurnal Ilmu Kesehatan Bhakti Husada Health Sciences Journal · doi:10.34305/jikbh.v12i2.327 · Cited by 8
Metadata
- Authors
- Liu, C. H., Zhang, E., Wong, G. T. F., Hyun, S., & Hahm, H. “.
- Affiliations
- Boston University (US)
- Corresponding author
- Liu, Cindy H.
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 290
- Pages
- 113172
- ISSN
- 0165-1781 (ISSN-L)
- PMC
- PMC7263263
- OpenAlex
- W3030361728
- Cited by
- 1,157
- References
- 48
- Citations by year
- 2026: 27 · 2025: 92 · 2024: 130 · 2023: 226 · 2022: 316 · 2021: 300 · 2020: 64
- FWCI
- 90.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Psychiatry Research (acceptedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Science Foundation
- Topics
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- COVID-19 pandemic, depression, anxiety, post-traumatic stress disorder, young adults, loneliness, distress tolerance, resilience, social support, family social support, racial and ethnic differences, mental health
- MeSH terms
- Patient Health Questionnaire, Betacoronavirus, COVID-19, SARS-CoV-2, Adolescent, Adult, Anxiety, Cross-Sectional Studies, Depression, Female, Humans, Loneliness, Male, Pneumonia, Viral, Quarantine, Social Support, Stress Disorders, Post-Traumatic, United States, Coronavirus Infections, Young Adult, Pandemics
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