Cited by 270Menopause: Health Impacts and TreatmentsEstrogen and related hormone effectsMaternal Mental Health During Pregnancy and Postpartum

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From menarche to menopause: Exploring the underlying biology of depression in women experiencing hormonal changes

Deecher, Darlene, Andree, Terrance H., Sloan, Diane, Schechter, Lee E.·2008·Psychoneuroendocrinology

DOI 10.1016/j.psyneuen.2007.10.006

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Abstract

Epidemiologic data consistently report an elevated prevalence of major depressive disorder (MDD) in women. This increase begins during adolescence and continues through the menopausal transition. Population-based clinical studies report an increase in the incidence of MDD during perimenopause compared to either the premenopausal or postmenopausal period. Evidence suggests that fluctuations and decline of hormonal levels are correlated with this observed increase in risk for MDD. A strong predictor of depression in the perimenopausal period is a previous history of MDD. However, recent studies revealed an increased risk of new onset depression in perimenopausal women without a history of MDD. Additionally, recent reports have indicated that the presence of vasomotor symptoms may be associated with an increased the risk for MDD. The objective of this paper is to review evidence that would support our hypothesis that neurotransmitter systems are affected by changes in hormonal status over the course of a woman's life, leading to increase vulnerability to perimenopausal depression. Relevant data from nonclinical experiments will be discussed in the context of observed clinical evidence of the risk for MDD before, during, and after the menopausal transition. A testable hypothesis will be proposed to advance our understanding of hormonal effects on mood.

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Authors: Deecher, D., Andree, T. H., Sloan, D., & Schechter, L. E.
Affiliations: Wyeth (US)
Corresponding author: Deecher, Darlene
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2008-01
Volume: 33
Issue: 1
Pages: 3-17
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/j.psyneuen.2007.10.006
OpenAlex: W2006693696
Cited by: 270
References: 142
Citations by year: 2026: 6 · 2025: 22 · 2024: 14 · 2023: 18 · 2022: 15 · 2021: 10 · 2020: 10 · 2019: 12 · 2018: 22 · 2017: 19 · 2016: 11 · 2015: 15 · 2014: 20 · 2013: 18 · 2012: 14
FWCI: 1.49
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords: perimenopausal depression, major depressive disorder, menopause, hormonal changes, sex differences in depression, neurotransmitter systems, vasomotor symptoms, menarche, postmenopausal depression, risk factors for depression, hypothalamic-pituitary-adrenal axis
MeSH terms: Adolescent, Adult, Aged, Animals, Major Depressive Disorder, Female, Humans, Menarche, Menopause, Menstrual Cycle, Middle Aged, Receptors, Adrenergic, Receptors, Serotonin, Gonadal Steroid Hormones, Women's Health

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From menarche to menopause: Exploring the underlying biology of depression in women experiencing hormonal changes

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