Cited by 104Prenatal Substance Exposure EffectsBirth, Development, and HealthStress Responses and Cortisol

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Maternal smoking during pregnancy and infant stress response: Test of a prenatal programming hypothesis

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Stroud, Laura R., Papandonatos, George D., Rodriguez, Daniel, McCallum, Meaghan, Salisbury, Amy L., Phipps, Maureen G., Lester, Barry, Huestis, Marilyn A., Niaura, Raymond, Padbury, James F., Marsit, Carmen J.·2014·Psychoneuroendocrinology

DOI 10.1016/j.psyneuen.2014.05.017PMC PMC4136384

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Abstract

Background Maternal smoking during pregnancy (MSDP) is associated with early and long-term neurobehavioral deficits; however mechanisms remain unknown. We tested the hypothesis that MSDP programs the hypothalamic pituitary adrenocortical (HPA) axis of the offspring leading to adverse outcomes. In an intensive, prospective study, we investigated associations between MSDP and infant cortisol stress response and explored whether alterations in cortisol response were mediated by epigenetic modulation of the placental glucocorticoid receptor gene (NR3C1).Methods Participants were 100 healthy mother-infant pairs (53% MSDP-exposed; 42% female) from a low income, racially/ethnically diverse sample (55% minorities). MSDP was assessed by timeline followback interview verified by saliva and meconium cotinine. Infant cortisol responses to a neurobehavioral exam were assessed seven times over the first postnatal month. Methylation of placental NR3C1 promoter exon 1F was assessed using bisulfite pyrosequencing in a subsample (n=45).Results MSDP-exposed infants showed significantly and persistently attenuated basal and reactive cortisol levels over the first postnatal month vs. unexposed infants. Exploratory analyses revealed that MSDP was associated with altered methylation of the placental NR3C1 promoter; degree of methylation of the placental NR3C1 was associated with infant basal and reactive cortisol over the first postnatal month and mediated effects of MSDP on infant basal cortisol.Conclusions Results provide initial support for our hypothesis that MSDP programs offspring HPA (dys)regulation. Epigenetic regulation of placental GR may serve as a novel underlying mechanism. Results may have implications for delineating pathways to adverse outcomes from MSDP.

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RETRACTED: Maternal adversity, glucocorticoids and programming of neuroendocrine function and behaviour
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Additional file 7 of Elevated methylation of the vault RNA2-1 promoter in maternal blood is associated with preterm birth
You, Y., Kwon, E. J., Hwang, H.-S., Choi, S.-J., Choi, S. K., & Kim, Y. J. (2021) · Figshare · doi:10.6084/m9.figshare.14954675
Additional file 5 of Elevated methylation of the vault RNA2-1 promoter in maternal blood is associated with preterm birth
You, Y., Kwon, E. J., Hwang, H.-S., Choi, S.-J., Choi, S. K., & Kim, Y. J. (2021) · Figshare · doi:10.6084/m9.figshare.14954669
Additional file 6 of Elevated methylation of the vault RNA2-1 promoter in maternal blood is associated with preterm birth
You, Y., Kwon, E. J., Hwang, H.-S., Choi, S.-J., Choi, S. K., & Kim, Y. J. (2021) · Figshare · doi:10.6084/m9.figshare.14954672
Additional file 3 of Elevated methylation of the vault RNA2-1 promoter in maternal blood is associated with preterm birth
You, Y., Kwon, E. J., Hwang, H.-S., Choi, S.-J., Choi, S. K., & Kim, Y. J. (2021) · Figshare · doi:10.6084/m9.figshare.14954663

Authors: Stroud, L. R., Papandonatos, G. D., Rodriguez, D., McCallum, M., Salisbury, A. L., Phipps, M. G., Lester, B., Huestis, M. A., Niaura, R., Padbury, J. F., & Marsit, C. J.
Affiliations: Brown University (US)
La Salle University (US)
Emory University (US)
National Institutes of Health (US)
Truth Initiative (US)
Dartmouth College (US)
Corresponding author: Stroud, Laura R.
ORCID: Stroud, Laura R.
Papandonatos, George D.
Rodriguez, Daniel
McCallum, Meaghan
Salisbury, Amy L.
Lester, Barry
Huestis, Marilyn A.
Niaura, Raymond
Padbury, James F.
Marsit, Carmen J.
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2014-10
Volume: 48
Pages: 29-40
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/j.psyneuen.2014.05.017
PMC: PMC4136384
OpenAlex: W2021299571
Cited by: 104
References: 64
Citations by year: 2026: 4 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 12 · 2020: 11 · 2019: 6 · 2018: 15 · 2017: 7 · 2016: 16 · 2015: 8 · 2014: 3
FWCI: 10.65
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (R01DA019558, R01DA031188)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: smoking during pregnancy, infant cortisol, hypothalamic-pituitary-adrenal axis, prenatal programming, glucocorticoid receptor, NR3C1, DNA methylation, placenta, epigenetics, stress response, neurobehavioral outcomes, cotinine
MeSH terms: Adolescent, Adult, Female, Humans, Hydrocortisone, Infant, Newborn, Placenta, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Receptors, Glucocorticoid, Smoking, Stress, Physiological, Case-Control Studies, DNA Methylation, Epigenesis, Genetic, Embryonic Development, Young Adult

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Maternal smoking during pregnancy and infant stress response: Test of a prenatal programming hypothesis

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