Cited by 158Birth, Development, and HealthChild Abuse and TraumaStress Responses and Cortisol

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Translating basic research knowledge on the biological embedding of early-life stress into novel approaches for the developmental programming of lifelong health

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Heim, Christine M., Entringer, Sonja, Buss, Claudia·2019·Psychoneuroendocrinology

DOI 10.1016/j.psyneuen.2018.12.011PMC PMC6561839

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Abstract

This review integrates scientific knowledge obtained over the past few decades on the biological mechanisms that contribute to the profound association between exposure to early adversity, including childhood trauma and prenatal stress, and the lifelong elevated risk to develop a broad range of diseases. We further discuss insights into gene-environment interactions moderating the association between early adversity and disease manifestation and we discuss the role of epigenetic and other molecular processes in the biological embedding of early adversity. Based on these findings, we propose potential mechanisms that may contribute to the intergenerational transmission of risk related to early adversity from the mother to the fetus. Finally, we argue that basic research knowledge on the biological embedding of early adversity must now be translated into novel intervention strategies that are mechanism-driven and sensitive to developmental timing. Indeed, to date, there are no diagnostic biomarkers of risk or mechanism-informed interventions that we can offer to victims of early adversity in order to efficiently prevent or reverse adverse health outcomes. Such translational efforts can be expected to have significant impact on both clinical practice and the public health system, and will promote precision medicine in pediatrics and across the lifespan.

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Authors: Heim, C. M., Entringer, S., & Buss, C.
Affiliations: University of California, Irvine (US)
Corresponding author: Entringer, Sonja
Buss, Claudia
ORCID: Entringer, Sonja
Buss, Claudia
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2019-07
Volume: 105
Pages: 123-137
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/j.psyneuen.2018.12.011
PMC: PMC6561839
OpenAlex: W2905562542
Cited by: 158
References: 227
Citations by year: 2026: 13 · 2025: 21 · 2024: 18 · 2023: 25 · 2022: 35 · 2021: 21 · 2020: 18 · 2019: 7
FWCI: 2.20
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: Bundesministerium für Bildung und Forschung (01KR1301, 01GL1743)
Deutsche Forschungsgemeinschaft (EXC257, EN 851/2-1)
European Research Council (ERC 639766, ERC 678073)
U.S. Public Health Service
National Institutes of Health (P50 HD-551411, 5UG3OD023349, R01 HD-065825, R01 AG-050455, R01 MH-105538, R01 HD-060628, MH 58922)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: early life stress, biological embedding, developmental programming, childhood trauma, prenatal stress, gene-environment interaction, epigenetics, intergenerational transmission, mother-to-child transmission, precision medicine, developmental timing, disease risk
MeSH terms: Psychological Trauma, Adverse Childhood Experiences, Animals, Brain, Female, Humans, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological, Epigenesis, Genetic, Telomere Shortening, Gene-Environment Interaction

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Translating basic research knowledge on the biological embedding of early-life stress into novel approaches for the developmental programming of lifelong health

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