Mechanisms of the placebo response

The inflammatory reflex

Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728 · see citing works

Descending control of pain

Millan, M. J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00009-6 · Cited by 3,035 · see citing works

Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network

Petrovic, P., Kalso, E., Petersson, K. M., & Ingvar, M. (2002) · Science · doi:10.1126/science.1067176 · Cited by 1,488 · see citing works

Reflex control of immunity

Tracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154 · see citing works

A Comprehensive Review of the Placebo Effect: Recent Advances and Current Thought

Price, D. D., Finniss, D. G., & Benedetti, F. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.113006.095941 · Cited by 1,146 · see citing works

THE MECHANISM OF PLACEBO ANALGESIA

Levine, J., Gordon, N., & Fields, H. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92762-9 · Cited by 1,094 · see citing works

Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease

de la Fuente‐Fernández, R., Ruth, T. J., Sossi, V., Schulzer, M., Calne, D. B., & Stoessl, A. J. (2001) · Science · doi:10.1126/science.1060937 · Cited by 991 · see citing works

State-dependent opioid control of pain

Fields, H. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1431 · Cited by 946 · see citing works

Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems

Amanzio, M., & Benedetti, F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00484.1999 · Cited by 899 · see citing works

Activation of the Opioidergic Descending Pain Control System Underlies Placebo Analgesia

Eippert, F., Bingel, U., Schoell, E. D., Yacubian, J., Klinger, R., Lorenz, J., & Büchel, C. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.014 · Cited by 839 · see citing works

Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses

Benedetti, F., Pollo, A., Lopiano, L., Lanotte, M., Vighetti, S., & Rainero, I. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04315.2003 · Cited by 788 · see citing works

Placebo Effects Mediated by Endogenous Opioid Activity on μ-Opioid Receptors

Zubieta, J.-K., Bueller, J. A., Jackson, L. R., Scott, D. J., Xu, Y., Koeppe, R. A., Nichols, T. E., & Stohler, C. S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0439-05.2005 · Cited by 779 · see citing works

Placebo and Nocebo Effects Are Defined by Opposite Opioid and Dopaminergic Responses

Scott, D. J., Stohler, C. S., Egnatuk, C. M., Wang, H., Koeppe, R. A., & Zubieta, J.-K. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.34 · Cited by 637 · see citing works

When words are painful: unraveling the mechanisms of the nocebo effect

Benedetti, F., Lanotte, M., Lopiano, L., & Colloca, L. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.020 · Cited by 636 · see citing works

Functional changes of the basal ganglia circuitry in Parkinson's disease

Blandini, F., Nappi, G., Tassorelli, C., & Martignoni, E. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00067-2 · Cited by 578 · see citing works

Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network

Bingel, U., Lorenz, J., Schoell, E., Weiller, C., & Büchel, C. (2006) · Pain · doi:10.1016/j.pain.2005.08.027 · Cited by 567 · see citing works

Placebo effects on human μ-opioid activity during pain

Wager, T. D., Scott, D. J., & Zubieta, J.-K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702413104 · Cited by 562 · see citing works

TREATMENT OF EXCESSIVE AXILLARY SWEATING

Gibbs, J. R. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91979-5 · Cited by 560 · see citing works

New Insights into the Placebo and Nocebo Responses

Enck, P., Benedetti, F., & Schedlowski, M. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.030 · Cited by 529 · see citing works

Direct evidence for spinal cord involvement in placebo analgesia

Eippert, F., Finsterbusch, J., Bingel, U., & Büchel, C. (2009) · Science · doi:10.1126/science.1180142 · Cited by 512 · see citing works

Individual differences in reward responding explain placebo-induced expectations and effects

Scott, D. J., Stohler, C. S., Egnatuk, C. M., Wang, H., Koeppe, R. A., & Zubieta, J.-K. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.028 · Cited by 466 · see citing works

How Placebos Change the Patient's Brain

Benedetti, F., Carlino, E., & Pollo, A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.81 · Cited by 446 · see citing works

The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect

Benedetti, F., Amanzio, M., Vighetti, S., & Asteggiano, G. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2947-06.2006 · Cited by 419 · see citing works

Mechanisms of placebo and placebo-related effects across diseases and treatments.

Benedetti, F. (2008) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.113006.094711 · Cited by 381 · see citing works

Somatotopic Activation of Opioid Systems by Target-Directed Expectations of Analgesia

Benedetti, F., Arduino, C., & Amanzio, M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-09-03639.1999 · Cited by 350 · see citing works

Descending analgesia – When the spine echoes what the brain expects

Goffaux, P., Redmond, W. J., Rainville, P., & Marchand, S. (2007) · Pain · doi:10.1016/j.pain.2006.11.011 · Cited by 342 · see citing works

Active Albuterol or Placebo, Sham Acupuncture, or No Intervention in Asthma

Wechsler, M. E., Kelley, J. M., Boyd, I. O. E., Dutile, S., Marigowda, G., Kirsch, I., Israel, E., & Kaptchuk, T. J. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103319 · Cited by 341 · see citing works

Loss of expectation-related mechanisms in Alzheimer’s disease makes analgesic therapies less effective

Benedetti, F., Arduino, C., Costa, S., Vighetti, S., Tarenzi, L., Rainero, I., & Asteggiano, G. (2006) · Pain · doi:10.1016/j.pain.2005.12.016 · Cited by 340 · see citing works

Prefrontal cortex modulates placebo analgesia

Krummenacher, P., Candia, V., Folkers, G., Schedlowski, M., & Schönbächler, G. (2010) · Pain · doi:10.1016/j.pain.2009.09.033 · Cited by 337 · see citing works

Dopamine release in human ventral striatum and expectation of reward.

de la Fuente-Fernández, R., Phillips, A., Zamburlini, M., Sossi, V., Calne, D., Ruth, T. J., & Stoessl, A. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00130-4 · Cited by 329 · see citing works

Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus

Benedetti, F., Colloca, L., Torre, E., Lanotte, M., Melcarne, A., Pesare, M., Bergamasco, B., & Lopiano, L. (2004) · Nature Neuroscience · doi:10.1038/nn1250 · Cited by 303 · see citing works

The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia

Benedetti, F. (1996) · Pain · doi:10.1016/0304-3959(95)00179-4 · Cited by 296 · see citing works

Neurobiological Mechanisms of Placebo Responses

Zubieta, J., & Stohler, C. S. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04424.x · Cited by 277 · see citing works

Placebo Effects – Understanding the Mechanisms in Health and Disease

Aebischer, B. (2016) · physioscience · doi:10.1055/s-0035-1567078 · Cited by 270 · see citing works

Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide

Benedetti, F., Amanzio, M., Casadio, C., Oliaro, A., & Maggi, G. (1997) · Pain · doi:10.1016/s0304-3959(97)03346-0 · Cited by 238 · see citing works

Behavioral conditioning of immunosuppression is possible in humans

Goebel, M. U., Trebst, A. E., Steiner, J., Xie, Y., Exton, M. S., Frede, S., Canbay, A. E., Michel, M. C., Heemann, U. W., & Schedlowski, M. (2002) · The FASEB Journal · doi:10.1096/fj.02-0389com · Cited by 238 · see citing works

Placebo Effects: Understanding the Mechanisms in Health and Disease

Ernst, E. (2009) · Focus on Alternative and Complementary Therapies · doi:10.1111/j.2042-7166.2009.tb05272.x · Cited by 227 · see citing works

Potentiation of placebo analgesia by proglumide

Benedetti, F., Amanzio, M., & Maggi, G. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92938-x · Cited by 219 · see citing works

Influences of Suggestion on Airway Reactivity in Asthmatic Subjects

Luparello, T. J., Lyons, H. A., Bleecker, E. R., & McFadden, E. R. (1968) · Psychosomatic Medicine · doi:10.1097/00006842-196811000-00002 · Cited by 213 · see citing works

A prefrontal non-opioid mechanism in placebo analgesia

Petrovic, P., Kalso, E., Petersson, K. M., Andersson, J., Fransson, P., & Ingvar, M. (2010) · Pain · doi:10.1016/j.pain.2010.03.011 · Cited by 182 · see citing works

Therapeutic application of transcranial magnetic stimulation in Parkinson's disease: The contribution of expectation

Strafella, A. P., Ko, J. H., & Monchi, O. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.005 · Cited by 176 · see citing works

Expectation modulates the response to subthalamic nucleus stimulation in Parkinsonian patients

Pollo, A., Torre, E., Lopiano, L., Rizzone, M. G., Lanotte, M., Cavanna, A. E., Bergamasco, B., & Benedetti, F. (2002) · Neuroreport · doi:10.1097/00001756-200208070-00006 · Cited by 170 · see citing works

Cholecystokinin and endogenous opioid peptides: Interactive influence on pain, cognition, and emotion

Hebb, A. L. O., Poulin, J.-F., Roach, S. P., Zacharko, R. M., & Drolet, G. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.008 · Cited by 160 · see citing works

The Powerful Placebo in Cough Studies?

Eccles, R. (2002) · Pulmonary Pharmacology & Therapeutics · doi:10.1006/pupt.2002.0364 · Cited by 146 · see citing works

Placebo-Induced Changes in Spinal Cord Pain Processing

Matre, D., Casey, K. L., & Knardahl, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4218-05.2006 · Cited by 134 · see citing works

Inducing placebo respiratory depressant responses in humans via opioid receptors

Benedetti, F., Amanzio, M., Baldi, S., Casadio, C., & Maggi, G. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00465.x · Cited by 131 · see citing works

The learned immune response: Pavlov and beyond

Schedlowski, M., & Pacheco‐López, G. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.08.007 · Cited by 119 · see citing works

Expectation of caffeine induces dopaminergic responses in humans

Kaasinen, V., Aalto, S., Någren, K., & Rinne, J. O. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03310.x · Cited by 118 · see citing works

Placebo analgesia and the heart

Pollo, A., Vighetti, S., Rainero, I., & Benedetti, F. (2003) · Pain · doi:10.1016/s0304-3959(02)00345-7 · Cited by 116 · see citing works

Placebo response in asthma: A robust and objective phenomenon

Kemeny, M. E., Rosenwasser, L. J., Panettieri, R. A., Rose, R. M., Berg-Smith, S. M., & Kline, J. N. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.03.016 · Cited by 115 · see citing works

Mechanisms of the placebo effect of sweet cough syrups

Eccles, R. (2005) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2005.10.004 · Cited by 111 · see citing works

Conditioning of cyclophosphamide-induced leukopenia in humans

Giang, D., Goodman, A. D., Schiffer, R. B., Mattson, D. H., Petrie, M., Cohen, N., & Ader, R. (1996) · Journal of Neuropsychiatry · doi:10.1176/jnp.8.2.194 · Cited by 100 · see citing works

Neural Substrates for Behaviorally Conditioned Immunosuppression in the Rat

Pacheco‐López, G., Niemi, M., Kou, W., Härting, M., Fandrey, J., & Schedlowski, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4230-04.2005 · Cited by 98 · see citing works

Placebo analgesia: findings from brain imaging studies and emerging hypotheses

Kong, J., Kaptchuk, T. J., Polich, G., Kirsch, I., & Gollub, R. L. (2007) · Reviews in the Neurosciences · doi:10.1515/revneuro.2007.18.3-4.173 · Cited by 97 · see citing works

The Patient's Brain

Benedetti, F. (2010) · Oxford University Press eBooks · doi:10.1093/med/9780199579518.001.0001 · Cited by 87 · see citing works

Peak B endorphin concentration in cerebrospinal fluid: reduced in chronic pain patients and increased during the placebo response

Lipman, J. J., Miller, B. E., Mays, K. S., Miller, M. N., North, W. C., & Byrne, W. L. (1990) · Psychopharmacology · doi:10.1007/bf02245754 · Cited by 86 · see citing works

Electrophysiological properties of thalamic, subthalamic and nigral neurons during the anti‐parkinsonian placebo response

Benedetti, F., Lanotte, M., Colloca, L., Ducati, A., Zibetti, M., & Lopiano, L. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.169425 · Cited by 80 · see citing works

The Patient's Brain: The neuroscience behind the doctor-patient relationship

Benedetti, F. (2010) · Cited by 68 · see citing works

Behavioural conditioning as the mediator of placebo responses in the immune system

Vits, S., Cesko, E., Enck, P., Hillen, U., Schadendorf, D., & Schedlowski, M. (2011) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0392 · Cited by 61 · see citing works

Placebo and Endogenous Mechanisms of Analgesia

Benedetti, F. (2007) · Springer eBooks · doi:10.1007/978-3-540-33823-9_14 · Cited by 58 · see citing works

The Antitussive Effect of Placebo Treatment on Cough Associated With Acute Upper Respiratory Infection

Lee, P. C. L., Jawad, M., Hull, J., West, W. H. L., Shaw, K., & Eccles, R. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000155667.59662.92 · Cited by 55 · see citing works

Experimental designs and brain mapping approaches for studying the placebo analgesic effect

Colloca, L., Benedetti, F., & Porro, C. (2008) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0593-6 · Cited by 53 · see citing works

The Effect of Placebo Conditioning on Capsaicin-Evoked Urge to Cough

Leech, J., Mazzone, S. B., & Farrell, M. J. (2012) · CHEST Journal · doi:10.1378/chest.12-0362 · Cited by 48 · see citing works

Subdyskinetic apomorphine responses in globus pallidus and subthalamus of parkinsonian patients: lack of clear evidence for the ‘indirect pathway’

Stefani, A., Bassi, A., Mazzone, P., Pierantozzi, M., Gattoni, G., Altibrandi, M. G., Giacomini, P., Peppe, A., Bernardi, G., & Stanzione, P. (2002) · Clinical Neurophysiology · doi:10.1016/s1388-2457(01)00683-6 · Cited by 45 · see citing works

Classically conditioned responses following repeated insulin and glucose administration in humans

Stockhorst, U., Steingrüber, H.-J., & Scherbaum, W. A. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00192-8 · Cited by 44 · see citing works

Calcineurin inhibition in splenocytes induced by pavlovian conditioning

Pacheco‐López, G., Riether, C., Doenlen, R., Engler, H., Niemi, M., Engler, A., Kavelaars, A., Heijnen, C. J., & Schedlowski, M. (2008) · The FASEB Journal · doi:10.1096/fj.08-115683 · Cited by 43 · see citing works

Emotional perception modulated by an opioid and a cholecystokinin agonist

Gospic, K., Gunnarsson, T., Fransson, P., Ingvar, M., Lindefors, N., & Petrovic, P. (2008) · Psychopharmacology · doi:10.1007/s00213-007-1032-4 · Cited by 39 · see citing works

Classically conditioned changes in plasma cortisol levels induced by dexamethasone in healthy men

Sabbioni, M. E. E., Bovbjerg, D. H., Mathew, S., Sikes, C. R., Lasley, B., & Stokes, P. E. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.14.9409548 · Cited by 32 · see citing works

Functional brain imaging of placebo analgesia: methodological challenges and recommendations

Rainville, P., & Duncan, G. H. (2006) · Pain · doi:10.1016/j.pain.2006.01.011 · Cited by 26 · see citing works

The role of CCK2 receptors in the homeostasis of the opioid system

Noble, F., & Roques, B. P. (2003) · Drugs of today · doi:10.1358/dot.2003.39.11.799467 · Cited by 21 · see citing works

The neocortical-immune axis

Tuohy, V. K. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.10.004 · Cited by 8 · see citing works

Evaluating psychosocial contributions to chronic pain outcomes

Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719 · see citing works

Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations

Edwards, R. R., Dworkin, R. H., Turk, D. C., Angst, M. S., Dionne, R., Freeman, R., Hansson, P., Haroutounian, S., Arendt-Nielsen, L., Attal, N., et al. (2016) · Pain · doi:10.1097/j.pain.0000000000000602 · Cited by 403 · see citing works

Genetics and the placebo effect: the placebome

Hall, K. T., Loscalzo, J., & Kaptchuk, T. J. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.02.009 · Cited by 271 · see citing works

Enhance placebo, avoid nocebo: How contextual factors affect physiotherapy outcomes

Testa, M., & Rossettini, G. (2016) · Manual Therapy · doi:10.1016/j.math.2016.04.006 · Cited by 259 · see citing works

Placebo analgesia and its opioidergic regulation suggest that empathy for pain is grounded in self pain

Rütgen, M., Seidel, E.-M., Silani, G., Riečanský, I., Hummer, A., Windischberger, C., Petrovic, P., & Lamm, C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511269112 · Cited by 208 · see citing works

A systematic review of sex differences in the placebo and the nocebo effect

Vambheim, S. M., & Flaten, M. A. (2017) · Journal of Pain Research · doi:10.2147/jpr.s134745 · Cited by 130 · see citing works

The influence of personality traits on the placebo/nocebo response

Kern, A., Kramm, C., Witt, C. M., & Barth, J. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2019.109866 · Cited by 119 · see citing works

Combining manual therapy with pain neuroscience education in the treatment of chronic low back pain: A narrative review of the literature

Puentedura, E. J., & Flynn, T. W. (2016) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2016.1194663 · Cited by 101 · see citing works

Oxytocin and the modulation of pain experience: Implications for chronic pain management

Tracy, L. M., Georgiou‐Karistianis, N., Gibson, S. J., & Giummarra, M. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.013 · Cited by 89 · see citing works

Mechanisms of placebo analgesia: A dual-process model informed by insights from cross-species comparisons

Schafer, S. M., Geuter, S., & Wager, T. D. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.008 · Cited by 78 · see citing works

The Powerful Placebo Effect in Cough: Relevance to Treatment and Clinical Trials

Eccles, R. (2019) · Lung · doi:10.1007/s00408-019-00305-5 · Cited by 71 · see citing works

Is it time to turn our attention toward central mechanisms for post-exertional recovery strategies and performance?

Rattray, B., Argus, C. K., Martin, K., Northey, J. M., & Driller, M. W. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00079 · Cited by 67 · see citing works

Advancing the understanding of placebo effects in psychological outcomes of exercise: Lessons learned and future directions

Lindheimer, J. B., Szabo, A., Raglin, J. S., & Beedie, C. (2020) · European Journal of Sport Science · doi:10.1080/17461391.2019.1632937 · Cited by 64 · see citing works

Blinding and sham control methods in trials of physical, psychological, and self-management interventions for pain (article II): a meta-analysis relating methods to trial results

Hohenschurz‐Schmidt, D., Draper‐Rodi, J., Vase, L., Scott, W., McGregor, A. H., Soliman, N., MacMillan, A., Olivier, A., Cherian, C. A., Corcoran, D., et al. (2022) · Pain · doi:10.1097/j.pain.0000000000002730 · Cited by 57 · see citing works

Does training general practitioners result in more shared decision making during consultations?

Sanders, A., Bensing, J. M., Essed, M. A. L. U., Magnée, T., de Wit, N. J., & Verhaak, P. F. M. (2016) · Patient Education and Counseling · doi:10.1016/j.pec.2016.10.002 · Cited by 54 · see citing works

Placebo and nocebo responses in drug trials of epilepsy

Zaccara, G., Giovannelli, F., & Schmidt, D. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2014.12.004 · Cited by 47 · see citing works

Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations

Edwards, R. R., Dworkin, R. H., Turk, D. C., Angst, M. S., Dionne, R. A., Freeman, R. L., Hansson, P. T., Haroutounian, S., Arendt‐Nielsen, L., Attal, N., et al. (2021) · PAIN Reports · doi:10.1097/pr9.0000000000000896 · Cited by 47 · see citing works

Contextually Aided Recovery (CARe): a scientific theory for innate healing

Newell, D., Lothe, L. R., & Raven, T. J. L. (2017) · Chiropractic & Manual Therapies · doi:10.1186/s12998-017-0137-z · Cited by 46 · see citing works

Efficacy paradox and proportional contextual effect (PCE)

Zhang, W., & Doherty, M. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.07.018 · Cited by 44 · see citing works

Beyond Sharing Unpleasant Affect—Evidence for Pain-Specific Opioidergic Modulation of Empathy for Pain

Rütgen, M., Wirth, E.-M., Riečanský, I., Hummer, A., Windischberger, C., Petrović, P., Silani, G., & Lamm, C. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa385 · Cited by 40 · see citing works

The relationship between the psychological stress of adolescents in school and the prevalence of chronic low back pain: a cross-sectional study in China

Mei, Q., Li, C., Yin, Y. H., Wang, Q., Wang, Q., & Deng, G. (2019) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-019-0283-2 · Cited by 42 · see citing works

Depressive Symptoms and Momentary Mood Predict Momentary Pain Among Rheumatoid Arthritis Patients

Graham‐Engeland, J. E., Zawadzki, M. J., Slavish, D. C., & Smyth, J. M. (2015) · Annals of Behavioral Medicine · doi:10.1007/s12160-015-9723-2 · Cited by 37 · see citing works

Perceived outcomes of spiritual healing and explanations - a qualitative study on the perspectives of German healers and their clients

Teut, M., Stöckigt, B., Holmberg, C., Besch, F., Witt, C. M., & Jeserich, F. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-240 · Cited by 35 · see citing works

The effectiveness of shared decision-making followed by positive reinforcement on physical disability in the long-term follow-up of patients with nonspecific low back pain in primary care: a clustered randomised controlled trial

Sanders, A., Bensing, J. M., Magnée, T., Verhaak, P. F. M., & de Wit, N. J. (2018) · BMC Family Practice · doi:10.1186/s12875-018-0776-8 · Cited by 35 · see citing works

Enhancing the Placebo Response: Functional Magnetic Resonance Imaging Evidence of Memory and Semantic Processing in Placebo Analgesia

Craggs, J. G., Price, D. D., & Robinson, M. E. (2014) · Journal of Pain · doi:10.1016/j.jpain.2013.12.009 · Cited by 34 · see citing works

Understanding and translating the knowledge about placebo effects

Geers, A. L., & Miller, F. G. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000082 · Cited by 34 · see citing works

Nocebo Effect in Randomized Clinical Trials of Antidepressants in Children and Adolescents: Systematic Review and Meta-Analysis

Rojas-Mirquez, J. C., Rodríguez-Zúñiga, M. J. M., Bonilla-Escobar, F. J., García‐Perdomo, H. A., Petkov, M. P., Becerra, L. R., Borsook, D., & Linnman, C. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00375 · Cited by 30 · see citing works

The influence of reward sensitivity, heart rate dynamics and EEG‐delta activity on placebo analgesia

Pascalis, V. D., & Scacchia, P. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.014 · Cited by 24 · see citing works

Effective connectivity predicts future placebo analgesic response: A dynamic causal modeling study of pain processing in healthy controls

Sevel, L. S., O’Shea, A. M., Letzen, J. E., Craggs, J. G., Price, D. D., & Robinson, M. E. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.01.056 · Cited by 27 · see citing works

Nocebo Effects on Muscular Performance – An Experimental Study About Clinical Situations

Zech, N., Seemann, M., Grzesiek, M., Breu, A., Seyfried, T., & Hansen, E. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00219 · Cited by 29 · see citing works

A candidate neuroimaging biomarker for detection of neurotransmission-related functional alterations and prediction of pharmacological analgesic response in chronic pain

Martins, D., Veronese, M., Turkheimer, F., Howard, M. A., Williams, S., & Dipasquale, O. (2021) · Brain Communications · doi:10.1093/braincomms/fcab302 · Cited by 28 · see citing works

Does adherence to treatment mediate the relationship between patients' treatment outcome expectancies and the outcomes of pain intensity and recovery from acute low back pain?

Haanstra, T. M., Kamper, S. J., Williams, C. M., Spriensma, A. S., Lin, C. C., Maher, C. G., de Vet, H. C. W., & Ostelo, R. (2015) · Pain · doi:10.1097/j.pain.0000000000000198 · Cited by 28 · see citing works

Towards Horizon 2020: challenges and advances for clinical mental health research – outcome of an expert survey

Feltz-Cornelis, C. M. V. D., van Os, J., Knappe, S., Schumann, G., Vieta, E., Wïttchen, H., Lewis, S. W., Elfeddali, I., Wahlbeck, K., Linszen, D. H., et al. (2014) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s59958 · Cited by 26 · see citing works

Periodontal Therapy Effects on Nitrite Related to Oral Bacteria: A 6‐Month Randomized Clinical Trial

Cortelli, S. C., Costa, F. O., Rodrigues, E., Cota, L. O. M., & Cortelli, J. R. (2015) · Journal of Periodontology · doi:10.1902/jop.2015.140678 · Cited by 24 · see citing works

Time-Dependent Negative Effects of Verbal and Non-verbal Suggestions in Surgical Patients—A Study on Arm Muscle Strength

Zech, N., Schrödinger, M., Seemann, M., Zeman, F., Seyfried, T., & Hansen, E. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.01693 · Cited by 21 · see citing works

Association of fatigue and depression with circulating levels of proinflammatory cytokines and epidermal growth factor receptor ligands: a correlative study of a placebo-controlled fatigue trial

Rich, T. A., Zhao, F., Cruciani, R. A., Cella, D. F., Manola, J. B., & Fisch, M. J. (2017) · Cancer Management and Research · doi:10.2147/cmar.s115835 · Cited by 21 · see citing works

The effect of occipital nerve field stimulation on the descending pain pathway in patients with fibromyalgia: a water PET and EEG imaging study

Ahmed, S., Plazier, M., Ost, J., Stassijns, G., Deleye, S., Ceyssens, S. K., Dupont, P. J., Stroobants, S. G., Staelens, S. G., Ridder, D. D., et al. (2018) · BMC Neurology · doi:10.1186/s12883-018-1190-5 · Cited by 21 · see citing works

Oxytocin Enhancement of the Placebo Effect May Be a Novel Therapy for Working Memory Impairments

Zhao, W., Becker, B., Yao, S., Ma, X., Kou, J., & Kendrick, K. M. (2018) · Psychotherapy and Psychosomatics · doi:10.1159/000495260 · Cited by 21 · see citing works

Expectancy of Stress-Reducing Aromatherapy Effect and Performance on a Stress-Sensitive Cognitive Task

Chamine, I., & Oken, B. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/419812 · Cited by 21 · see citing works

Ultrasound detected synovial change and pain response following intra-articular injection of corticosteroid and a placebo in symptomatic osteoarthritic knees: a pilot study

Hall, M. C., Doherty, S. A., Courtney, P., Latief, K., Zhang, W., & Doherty, M. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-205206 · Cited by 18 · see citing works

Stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans

Crawford, L. S., Meylakh, N., Macey, P. M., Macefield, V. G., Keay, K. A., & Henderson, L. A. (2023) · Communications Biology · doi:10.1038/s42003-023-04951-7 · Cited by 18 · see citing works

Coaches' attitudes towards placebo interventions in sport

Szabó, A., & Müller, A. (2015) · European Journal of Sport Science · doi:10.1080/17461391.2015.1019572 · Cited by 15 · see citing works

A Review of Intravenous Lidocaine Infusion Therapy for Paediatric Acute and Chronic Pain Management

LAUDER, G. R. (2017) · InTech eBooks · doi:10.5772/66771 · Cited by 15 · see citing works

Endogenous Antinociceptive System and Potential Ways to Influence It

Yamamotová, A. (2019) · Physiological Research · doi:10.33549/physiolres.934351 · Cited by 14 · see citing works

The placebo and nocebo effects in functional urology

Mostafaei, H., Jilch, S., Carlin, G. L., Mori, K., Quhal, F., Pradère, B., Laukhtina, E., Schuettfort, V. M., Aydh, A., Motlagh, R. S., et al. (2021) · Nature Reviews Urology · doi:10.1038/s41585-021-00545-2 · Cited by 14 · see citing works

The Optimal Learning Cocktail for Placebo Analgesia: A Randomized Controlled Trial Comparing Individual and Combined Techniques

van Lennep, J. P. A., van Middendorp, H., Veldhuijzen, D. S., Peerdeman, K. J., Blythe, J. S., Thomaidou, M. A., Heyman, T., & Evers, A. W. M. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.07.009 · Cited by 11 · see citing works

Placebo and nocebo effects in the neurological practice

Bittar, C., & Nascimento, O. J. M. (2015) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20140180 · Cited by 11 · see citing works

Reduced Need for Rescue Antiemetics and Improved Capacity to Eat in Patients Receiving Acupuncture Compared to Patients Receiving Sham Acupuncture or Standard Care during Radiotherapy

Enblom, A., Steineck, G., Hammar, M. L., & Börjeson, S. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/5806351 · Cited by 11 · see citing works

Complex Role of Hypnotizability in the Cognitive Control of Pain

Santarcangelo, E. L., & Consoli, S. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.02272 · Cited by 11 · see citing works

Placebos in the era of open‐label trials: An update for clinicians

Sagy, I., Abres, J., Winnick, A. A., & Jotkowitz, A. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.13038 · Cited by 10 · see citing works

Research on placebo analgesia is relevant to clinical practice

Gay, C. W., & Bishop, M. D. (2014) · Chiropractic & Manual Therapies · doi:10.1186/2045-709x-22-6 · Cited by 8 · see citing works

Could Relationship-Based Learnt Beliefs and Expectations Contribute to Physiological Vulnerability of Chronic Pain? Making a Case to Consider Attachment in Pain Research

Stamp, G. E., Wadley, A. L., & Iacovides, S. (2024) · Journal of Pain · doi:10.1016/j.jpain.2024.104619 · Cited by 7 · see citing works

Placebo Studies and Patient Care: Where Are the Nurses?

Annoni, M., Buergler, S., Stewart‐Ferrer, S., & Blease, C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.591913 · Cited by 7 · see citing works

Upregulation of reward mesolimbic activity and immune response to vaccination: a randomized controlled trial

Lubianiker, N., Koren, T., Djerassi, M., Sirotkin, M., Singer, N., Jalon, I., Lerner, A., Sar-El, R., Sharon, H., Shahar, M., et al. (2026) · Nature Medicine · doi:10.1038/s41591-025-04140-5 · Cited by 7 · see citing works

Which Regional Pain Rating Best Predicts Patient‐Reported Improvement in Lumbar Radiculopathy?

Bicket, M. C., Pasquina, P. F., & Cohen, S. P. (2017) · Pain Practice · doi:10.1111/papr.12569 · Cited by 6 · see citing works

Influences of hypnotic suggestibility, contextual factors, and EEG alpha on placebo analgesia

Pascalis, V. D., Scacchia, P., & Vecchio, A. (2021) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.2020.1863182 · Cited by 7 · see citing works

Analgesics in Chronic Back Pain

Kamping, S., Müller, M., Klinger, R., Schmitz, J., & Flor, H. (2014) · Zeitschrift für Psychologie · doi:10.1027/2151-2604/a000182 · Cited by 6 · see citing works

Muscle injections with lidocaine improve resting fatigue and pain in patients with chronic fatigue syndrome

Staud, R. M., Kizer, T., & Robinson, M. E. (2017) · Journal of Pain Research · doi:10.2147/jpr.s139466 · Cited by 6 · see citing works

Brain and cortisol responses to smoking cues are linked in tobacco‐smoking individuals

Wanger, T. J., de Moura, F. B., Ashare, R. L., Loughead, J., Lukas, S. E., Lerman, C. E., & Janes, A. C. (2023) · Addiction Biology · doi:10.1111/adb.13338 · Cited by 6 · see citing works

The Analogy between Tinnitus and Chronic Pain: A Phenomenological Approach

Noreña, A. J. (2023) · Brain Sciences · doi:10.3390/brainsci13081129 · Cited by 5 · see citing works

The impact of a focused behavioral intervention on brain cannabinoid signaling and interoceptive function: Implications for mood and anxiety

Muzik, O., Mann, T., Kopchick, J. J., Chowdury, A., Yacou, M. A., Vadgama, J., Bonello, D., & Diwadkar, V. A. (2023) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2023.100035 · Cited by 5 · see citing works

Use of predictive models in CNS diseases

Goméni, R. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.10.004 · Cited by 5 · see citing works

Forebrain networks driving brainstem pain modulatory circuits during nocebo hyperalgesia in healthy humans

Crawford, L. S., Yang, S., Meylakh, N., Sattarov, L., Ramachandran, A., Macefield, V. G., Keay, K. A., & Henderson, L. A. (2025) · Pain · doi:10.1097/j.pain.0000000000003604 · Cited by 4 · see citing works

Characterization of the adverse events profile of placebo-treated patients in randomized controlled trials on drug-resistant focal epilepsies

Giovannelli, F., Zaccara, G., Cincotta, M., Loiacono, G., & Verrotti, A. (2014) · Journal of Neurology · doi:10.1007/s00415-014-7535-0 · Cited by 4 · see citing works

Current and Emerging Technologies to Address the Placebo Response Challenge in CNS Clinical Trials: Promise, Pitfalls, and Pathways Forward.

Horan, W. P., Sachs, G. S., Velligan, D. I., Davis, M., Keefe, R. S. E., Khin, N. A., Butlen‐Ducuing, F., & Harvey, P. D. (2024) · PubMed Central · Cited by 3 · see citing works

Impact of Verbal Suggestions on Finger Flexor Activation and Strength in Healthy Individuals

Zaworski, K., Kadłubowska, M., & Baj–Korpak, J. (2023) · Medical Science Monitor · doi:10.12659/msm.941548 · Cited by 4 · see citing works

A randomised controlled trial of ‘clockwise’ ultrasound for low back pain

Louw, A., Zimney, K. J., Landers, M. R., Luttrell, M., Clair, B., & Mills, J. (2016) · South African Journal of Physiotherapy · doi:10.4102/sajp.v72i1.306 · Cited by 3 · see citing works

Prise en charge de la douleur aux urgences : mise au point

Lvovschi, V.-E., & Aubrun, F. (2014) · Journal Européen des Urgences et de Réanimation · doi:10.1016/j.jeurea.2014.03.001 · Cited by 2 · see citing works

Anticipation and Placebo Analgesia

Nathan, D. E., Ludman, T., & Colloca, L. (2017) · Springer eBooks · doi:10.1007/978-3-319-48046-6_7 · Cited by 2 · see citing works

No effect of a pulsed magnetic field on induced ischemic muscle pain. A double-blind, randomized, placebo-controlled trial

Szemerszky, R., Szabolcs, Z., Bogdány, T., Jánossy, G., Thuróczy, G., & Köteles, F. G. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.11.005 · Cited by 2 · see citing works

Placebo Effects in the Treatment of Depression—Implications for the Psychedelic Renaissance

Ansari, M., Elliot, S. I., Holmes, S. E., & Sanacora, G. (2025) · Neurologic Clinics · doi:10.1016/j.ncl.2025.08.009 · Cited by 1 · see citing works

Placebo Effects in Modern Medicine: Mechanisms, Clinical Evidence, Limitations, and Future Directions

Alnasralla, M. B., & Nasralla, B. H. (2026) · Cureus · doi:10.7759/cureus.100612 · Cited by 2 · see citing works

Influence of Counseling Intervention on the Effectiveness of a Revitalizing Medicinal Product in Healthy Volunteers, Using a Brain Monitoring System

Isawa, M., Shimizu, A., Miyashita, E., Itoh, H., Nishimura, T., Tomi, M., Shimada, H., Saito, H., & Nakashima, E. (2014) · Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) · doi:10.5649/jjphcs.40.558 · Cited by 1 · see citing works

Placebo effects in cough

Eccles, R. (2023) · doi:10.1093/med/9780197645444.003.0010 · Cited by 1 · see citing works

Die Macht der Worte – Placebo- und Nocebo-Effekte in der Physiotherapie

Rutten, G. M. (2019) · physiopraxis · doi:10.1055/a-1010-0240 · Cited by 1 · see citing works

Behavioral Health Interventions for CRPS

Richardson, P. A., Poupore‐King, H., Griffin, A. T., Cooley, C., & Bhandari, R. P. (2021) · Springer eBooks · doi:10.1007/978-3-030-75373-3_6 · Cited by 1 · see citing works

Editorial: Placebo Response in Child and Adolescent Psychiatry: To Mitigate or to Harness?

Singh, M. K. (2025) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2025.01.024 · Cited by 1 · see citing works

Efekt placebo/nocebo prognozy lekarskiej

Jonkisz, A., Szmaglińska, K., & Fajler, M. (2017) · Medycyna Ogólna i Nauki o Zdrowiu · doi:10.5604/20834543.1235618

Placebo and nocebo effects in the neurological practice placebo e nocebo na prática neurológica

Bittar, C. (2014)

Een training in gedeelde besluitvorming

Sandersd, A. (2017) · Huisarts en Wetenschap · doi:10.1007/s12445-017-0354-7

Eficácia da aplicação de ondas de choque para indução ao crescimento vascular em pacientes com angina refratária: avaliação pela ecocardiografia de perfusão miocádica em tempo real

Ceccon, C. L. (2018) · doi:10.11606/t.5.2018.tde-13062018-094940

Efeito placebo aplicado a ambientes clínicos e de desempenho físico

Canestri, R., Brietzke, C., de Lima, F. D. R., Vinícius, Í., Franco-Alvarenga, P. E., & Pires, F. D. O. (2020) · Conexões · doi:10.20396/conex.v18i0.8657859

Neuropsychopharmacotherapy: Aspects of Placebo Effects

Netter, P. (2021) · NeuroPsychopharmacotherapy · doi:10.1007/978-3-319-56015-1_441-1

β–alanine: performance effects, usage and side effects

Kelly, V. G. (2017) · The University of Queensland · doi:10.14264/uql.2017.370

Влияние различных видов вербального внушения на динамику решения задачи «9 свинок»

Решетников, М. (2020) · Психологические исследования · doi:10.54359/ps.v13i72.186

La respuesta placebo en el consumo de cocaína: una revisión sistemática

Rueda, E., & Navarro, J. F. (2022) · Psiquiatría Biológica · doi:10.1016/j.psiq.2022.100370

Neuropsychopharmacotherapy: Aspects of Placebo Effects

Netter, P. (2022) · Springer eBooks · doi:10.1007/978-3-030-62059-2_441

Back-to-back consultations

Sanders, A. (2023) · doi:10.33540/1825

Upregulation of Reward Mesolimbic Activity via fMRI-Neurofeedback Improves Vaccination Efficiency in HumansPreprint

Lubianiker, N., Koren, T., Djerassi, M., Sirotkin, M., Singer, N., Jalon, I., Lerner, A., Sar-El, R., Sharon, H., Azulay‐Debby, H., et al. (2024) · medRxiv · doi:10.1101/2024.09.18.24313899

Are there Gender Differences in Pain and Placebo Analgesia

Harviken, I. E. (2014) · NORA - Norwegian Open Research Archives

Psykologiska och fysiologiska effekter av placebo

Johansson, M. (2014) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Methodological considerations for designing and conducting open-label placebo trials

Hartmann, H., Müßgens, D., Asan, L., Skvortsova, A., Kleine‐Borgmann, J., Schmidt, K., Fernandez, A., Phalip, J., Wessels, J., Valerio, M., et al. (2026) · Pain · doi:10.1097/j.pain.0000000000004071

S.02.03 Placebo analgesia and beyond – the role of expectations in experiencing the world

Petrović, P. (2013) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(13)70128-7

The placebo response: how words and rituals change the patient's brain

Benedetti, F., & Amanzio, M. (2011) · Patient Education and Counseling · doi:10.1016/j.pec.2011.04.034 · Cited by 132 · see citing works

The placebo response in conditions other than pain

Colloca, L., Lopiano, L., Benedetti, F., & Lanotte, M. (2005) · Seminars in Pain Medicine · doi:10.1016/j.spmd.2005.02.006 · Cited by 12 · see citing works

The placebo response: science versus ethics and the vulnerability of the patient

Benedetti, F. (2012) · World Psychiatry · doi:10.1016/j.wpsyc.2012.05.003 · Cited by 25 · see citing works

Symposium Neurobiological Mechanisms of the Placebo Effect

Benedetti, F., Mayberg, H. S., Wager, T. D., Stohler, C. S., & Zubieta, J.-K. (2015)