The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria
Open accessAbstract
Oxidative stress-induced lipid peroxidation has been associated with human physiology and diseases including cancer. Overwhelming data suggest that reactive lipid mediators generated from this process, such as 4-hydroxynonenal (4-HNE), are biomarkers for oxidative stress and important players for mediating a number of signaling pathways. The biological effects of 4-HNE are primarily due to covalent modification of important biomolecules including proteins, DNA, and phospholipids containing amino group. In this review, we summarize recent progress on the role of 4-HNE in pathogenesis of cancer and focus on the involvement of mitochondria: generation of 4-HNE from oxidation of mitochondria-specific phospholipid cardiolipin; covalent modification of mitochondrial proteins, lipids, and DNA; potential therapeutic strategies for targeting mitochondrial ROS generation, lipid peroxidation, and 4-HNE.
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Cites
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Ferroptosis in cancer and cancer immunotherapy
Zhao, L., Zhou, X., Xie, F., Zhang, L., Yan, H., Huang, J., Zhang, C., Zhou, F., Chen, J., & Zhang, L. (2022) · Cancer Communications · doi:10.1002/cac2.12250 · Cited by 684
Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators
Kajarabille, N., & Latunde-Dada, G. O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194968 · Cited by 668
Hypoxia, oxidative stress and inflammation
McGarry, T., Biniecka, M., Veale, D. J., & Fearon, U. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.03.042 · Cited by 601
Biomarkers of Oxidative Stress and Antioxidant Defense
Demirci-Çekiç, S., Özkan, G., Avan, A. N., Uzunboy, S., Çapanoğlu, E., & Apak, R. (2022) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.114477 · Cited by 587
Metadata
- Authors
- Zhong, H., & Yin, H.
- Venue
- Redox Biology
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 4
- Pages
- 193-199
- ISSN
- 2213-2317 (ISSN-L)
- OpenAlex
- W1989509611
- Cited by
- 536
- References
- 55
- FWCI
- 13.57
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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