A signalling role for 4‐hydroxy‐2‐nonenal in regulation of mitochondrial uncoupling

Free radicals in biology and medicine

Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works

Free Radicals in Biology and Medicine

Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990 · see citing works

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

Esterbauer, H., Schaur, R. J., & Zollner, H. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90192-6 · Cited by 6,672 · see citing works

Topology of superoxide production from different sites in the mitochondrial electron transport chain

St-Pierre, J., Buckingham, J. A., Roebuck, S. J., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207217200 · Cited by 1,545 · see citing works

Superoxide activates mitochondrial uncoupling proteins

Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., et al. (2002) · Nature · doi:10.1038/415096a · Cited by 1,382 · see citing works

Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression

Boss, O., Samec, S., Paoloni‐Giacobino, A., Rossier, C., Dulloo, A. G., Seydoux, J., Muzzin, P., & Giacobino, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00384-0 · Cited by 1,041 · see citing works

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes.

Zhang, C.-Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y.-B., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00378-6 · Cited by 917 · see citing works

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

Ricquier, D., & Bouillaud, F. (2000) · Biochemical Journal · doi:10.1042/bj3450161 · Cited by 806 · see citing works

Energy metabolism in uncoupling protein 3 gene knockout mice

Vidal-Puig, A. J., Grujic, D., Zhang, C.-Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Wade, J., Mootha, V., Cortright, R., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910179199 · Cited by 677 · see citing works

Uncoupling Protein 2, in Vivo Distribution, Induction upon Oxidative Stress, and Evidence for Translational Regulation

Pecqueur, C., Alves‐Guerra, M., Gelly, C., Lévi-Meyrueis, C., Couplan, E., Collins, S., Ricquier, D., Bouillaud, F., & Miroux, B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006938200 · Cited by 474 · see citing works

Reactive oxygen species, mitochondria, apoptosis and aging

Papa, S., & Skulachev, V. P. (1997) · Springer eBooks · doi:10.1007/978-1-4615-6111-8_47 · Cited by 462 · see citing works

Mitochondrial adenine nucleotide translocase is modified oxidatively during aging

Yan, L.-J., & Sohal, R. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.12896 · Cited by 414 · see citing works

Superoxide Activates Mitochondrial Uncoupling Protein 2 from the Matrix Side

Echtay, K. S., Murphy, M. P., Smith, R. A. J., Talbot, D. A., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208262200 · Cited by 388 · see citing works

Alterations in mitochondrial membrane fluidity by lipid peroxidation products

Chen, J. J., & Yu, B. P. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90167-8 · Cited by 369 · see citing works

Selective Inactivation of α-Ketoglutarate Dehydrogenase and Pyruvate Dehydrogenase: Reaction of Lipoic Acid with 4-Hydroxy-2-nonenal

Humphries, K. M., & Szweda, L. I. (1998) · Biochemistry · doi:10.1021/bi981512h · Cited by 357 · see citing works

Uncoupling proteins 2 and 3 are highly active H ⁺ transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)

Echtay, K. S., Winkler, E., Frischmuth, K., & Klingenberg, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1416 · Cited by 313 · see citing works

4-Hydroxyhexenal Is a Potent Inducer of the Mitochondrial Permeability Transition

Kristal, B. S., Park, B. K., & Yu, B. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6033 · Cited by 253 · see citing works

Mitochondrial uncoupling as a target for drug development for the treatment of obesity.

Harper, J. A., Dickinson, K., & Brand, M. D. (2001) · Obesity Reviews · doi:10.1046/j.1467-789x.2001.00043.x · Cited by 250 · see citing works

Structural Definition of Early Lysine and Histidine Adduction Chemistry of 4-Hydroxynonenal

Nadkarni, D. V., & Sayre, L. M. (1995) · Chemical Research in Toxicology · doi:10.1021/tx00044a014 · Cited by 235 · see citing works

Inhibition of NADH-Linked Mitochondrial Respiration by 4-Hydroxy-2-nonenal

Humphries, K. M., Yoo, Y., & Szweda, L. I. (1998) · Biochemistry · doi:10.1021/bi971958i · Cited by 231 · see citing works

Bioenergetics: a practical approach

(1997) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(97)84211-5 · Cited by 211 · see citing works

The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3

Cadenas, S., Echtay, K. S., Harper, J. A., Jekabsons, M. B., Buckingham, J. A., Grau, E., Abuin, A., Chapman, H., Clapham, J. C., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109736200 · Cited by 199 · see citing works

Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2

Rial, E., González‐Barroso, M., Fleury, C., Iturrizaga, S., Sanchı́s, D., Jiménez‐Jiménez, J., Ricquier, D., Goubern, M., & Bouillaud, F. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.5827 · Cited by 195 · see citing works

A Novel Regulatory Pathway of Brown Fat Thermogenesis

Alvarez, R., de Andrés, J., Yubero, P., Viñas, O., Mampel, T., Iglesias, R., Giralt, M., & Villarroya, F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5666 · Cited by 194 · see citing works

Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3

BRAND, M. D., PAMPLONA, R., PORTERO-OTÍN, M., REQUENA, J. R., ROEBUCK, S. J., BUCKINGHAM, J. A., CLAPHAM, J. C., & CADENAS, S. (2002) · Biochemical Journal · doi:10.1042/bj20021077 · Cited by 184 · see citing works

The ADP-ATP Carrier in Mitochondrial Membranes

Klingenberg, M. (1976) · Springer eBooks · doi:10.1007/978-1-4684-2658-8_15 · Cited by 182 · see citing works

No Evidence for a Basal, Retinoic, or Superoxide-induced Uncoupling Activity of the Uncoupling Protein 2 Present in Spleen or Lung Mitochondria

Couplan, E., del Mar Gonzalez-Barroso, M., Alves-Guerra, M. C., Ricquier, D., Goubern, M., & Bouillaud, F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202535200 · Cited by 161 · see citing works

Inhibition of adenine nucleotide translocator by lipid peroxidation products

Chen, J. J., Bertrand, H. A., & Yu, B. P. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)00066-7 · Cited by 128 · see citing works

Selective cleavage of thioether linkage in proteins modified with 4-hydroxynonenal.

Uchida, K., & Stadtman, E. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5611 · Cited by 125 · see citing works

Chemical Characterization of a Protein-4-hydroxy-2-nonenal Cross-Link: Immunochemical Detection in Mitochondria Exposed to Oxidative Stress

Cohn, J. A., Tsai, L., Friguet, B., & Szweda, L. I. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0156 · Cited by 120 · see citing works

A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast

Stuart, J. A., Harper, J. A., Brindle, K. M., Jekabsons, M. B., & Brand, M. D. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3560779 · Cited by 116 · see citing works

Homologues of the uncoupling protein from brown adipose tissue (UCP1): UCP2, UCP3, BMCP1 and UCP4

Bouillaud, F., Couplan, E., Pecqueur, C., & Ricquier, D. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00241-3 · Cited by 111 · see citing works

Measurement of mitochondrial protonmotive force

Brand, M. D. (1995) · doi:10.1093/oso/9780199634897.003.0003 · Cited by 96 · see citing works

Molecular basis of age-dependent changes in the activity of adenine nucleotide translocase

Nohl, H., & Krämer, R. (1980) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(80)90112-8 · Cited by 94 · see citing works

stress sensitive B Encodes an Adenine Nucleotide Translocase in Drosophila melanogaster

Zhang, Y., Roote, J., Brogna, S., Davis, A. W., Barbash, D. A., Nash, D., & Ashburner, M. (1999) · Genetics · doi:10.1093/genetics/153.2.891 · Cited by 93 · see citing works

Identification of Bovine Heart Cytochrome c Oxidase Subunits Modified by the Lipid Peroxidation Product 4-Hydroxy-2-nonenal,

Musatov, A., Carroll, C. A., Liu, Y.-C., Henderson, G. I., Weintraub, S. T., & Robinson, N. C. (2002) · Biochemistry · doi:10.1021/bi025896u · Cited by 88 · see citing works

4-Hydroxy-2-nonenal–Protein Adducts and Apoptosis in Murine Lung Cells after Acute Ozone Exposure

Kirichenko, A., Li, L., Morandi, M. T., et al. (1996) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.0307 · Cited by 77 · see citing works

A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast

Stuart, J. A., Harper, J. A., Brindle, K. M., et al. (2001) · Biochemical Journal · doi:10.1042/bj3560779 · Cited by 77 · see citing works

Diabetes induces an impairment in the proteolytic activity against oxidized proteins and a heterogeneous effect in nonenzymatic protein modifications in the cytosol of rat liver and kidney.

Portero‐Otín, M., Pamplona, R., Ruiz, M. C., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.11.2215 · Cited by 67 · see citing works

Nucleotide binding to human uncoupling protein-2 refolded from bacterial inclusion bodies

Jekabsons, M. B., Echtay, K. S., & Brand, M. D. (2002) · Biochemical Journal · doi:10.1042/bj20020469 · Cited by 29 · see citing works

The Effect of the Lipid Peroxidation Product 4-Hydroxynonenal and of its Metabolite 4-Hydroxynonenoic Acid on Respiration of Rat Kidney Cortex Mitochondria

Ullrich, O., Henke, W., Grune, T., et al. (1996) · Free Radical Research · doi:10.3109/10715769609088041 · Cited by 17 · see citing works

Modulation of matrix Ca2+ content by the ADP/ATP carrier in brown adipose tissue mitochondria. Influence of membrane lipid composition

Chávez, E., Moreno‐Sánchez, R., Torres-Marquez, M. E., et al. (1996) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf02109905 · Cited by 16 · see citing works

Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

Brand, M. D., Affourtit, C., Esteves, T. C., Green, K., Lambert, A. J., Miwa, S., Pakay, J. L., & Parker, N. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.034 · Cited by 1,032 · see citing works

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

Fedorenko, A., Lishko, P. V., & Kirichok, Y. (2012) · Cell · doi:10.1016/j.cell.2012.09.010 · Cited by 968 · see citing works

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

Passos, J. F., Saretzki, G., Ahmed, S., Nelson, G., Richter, T., Peters, H., Wappler, I., Birket, M. J., Harold, G., Schaeuble, K., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050110 · Cited by 796 · see citing works

Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

Brand, M. D., & Esteves, T. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.002 · Cited by 785 · see citing works

Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer

Speakman, J. R., Talbot, D. A., Selman, C., Snart, S., McLaren, J. S., Redman, P., Krol, E., Jackson, D. M., Johnson, M. S., & Brand, M. D. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00097.x · Cited by 761 · see citing works

Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions

Catalá, A. (2009) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2008.09.004 · Cited by 745 · see citing works

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

Sivitz, W. I., & Yorek, M. A. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2531 · Cited by 742 · see citing works

Mitochondrial Energetics in the Heart in Obesity-Related Diabetes

Boudina, S., Sena, S., Theobald, H., Sheng, X., Wright, J. J., Hu, X. X., Aziz, S., Johnson, J. I., Bugger, H., Zaha, V. G., et al. (2007) · Diabetes · doi:10.2337/db07-0481 · Cited by 586 · see citing works

Mitochondrial uncoupling, ROS generation and cardioprotection

Cadenas, S. (2018) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2018.05.019 · Cited by 591 · see citing works

Mitochondria and Endothelial Function

Kluge, M. A., Fetterman, J. L., & Vita, J. A. (2013) · Circulation Research · doi:10.1161/circresaha.111.300233 · Cited by 508 · see citing works

Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function

Stowe, D. F., & Camara, A. K. S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2331 · Cited by 471 · see citing works

Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes

Schrauwen, P., & Hesselink, M. K. C. (2004) · Diabetes · doi:10.2337/diabetes.53.6.1412 · Cited by 408 · see citing works

The basal proton conductance of mitochondria depends on adenine nucleotide translocase content

Brand, M. D., Pakay, J. L., Ocloo, A., Kokoszka, J., Wallace, D. C., Brookes, P. S., & Cornwall, E. J. (2005) · Biochemical Journal · doi:10.1042/bj20050890 · Cited by 410 · see citing works

The efficiency and plasticity of mitochondrial energy transduction.

Brand, M. D. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330897 · Cited by 406 · see citing works

Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H ₂ O ₂ Signaling

Rigoulet, M., Yoboue, E. D., & Devin, A. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3363 · Cited by 394 · see citing works

The role of mitochondria in protection of the heart by preconditioning

Halestrap, A. P., Clarke, S. J., & Khaliulin, I. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.05.008 · Cited by 390 · see citing works

Redox control of inflammation in macrophages

Brüne, B., Dehne, N., Grossmann, N., Jung, M., Namgaladze, D., Schmid, T., von Knethen, A., & Weigert, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4785 · Cited by 377 · see citing works

The role of the mitochondrial permeability transition pore in heart disease

Halestrap, A. P., & Pasdois, P. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.12.017 · Cited by 362 · see citing works

Formation and signaling actions of electrophilic lipids

Schopfer, F. J., Cipollina, C., & Freeman, B. A. (2011) · Chemical Reviews · doi:10.1021/cr200131e · Cited by 299 · see citing works

Ablation of PGC-1β Results in Defective Mitochondrial Activity, Thermogenesis, Hepatic Function, and Cardiac Performance

Lelliott, C. J., Medina-Gomez, G., Petrovic, N., Kis, A., Feldmann, H. M., Bjursell, M., Parker, N., Curtis, K., Campbell, M., Hu, P., et al. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040369 · Cited by 280 · see citing works

Mitochondrial dysfunction and lipotoxicity

Schrauwen, P., Schrauwen-Hinderling, V., Hoeks, J., & Hesselink, M. K. C. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.09.011 · Cited by 268 · see citing works

Physiological Increases in Uncoupling Protein 3 Augment Fatty Acid Oxidation and Decrease Reactive Oxygen Species Production Without Uncoupling Respiration in Muscle Cells

MacLellan, J. D., Gerrits, M. F., Gowing, A., Smith, P. J. S., Wheeler, M. B., & Harper, M.-E. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2343 · Cited by 213 · see citing works

Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer’s Disease

Cioffi, F., Adam, R. H. I., & Broersen, K. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190863 · Cited by 204 · see citing works

Mitochondrial Uncoupling: A Key Contributor to Reduced Cardiac Efficiency in Diabetes

Boudina, S., & Abel, E. D. (2006) · Physiology · doi:10.1152/physiol.00008.2006 · Cited by 199 · see citing works

Metabolomics of Human Brain Aging and Age-Related Neurodegenerative Diseases

Jové, M., Portero-Otín, M., Naudí, A., Ferrer, I., & Pamplona, R. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000091 · Cited by 195 · see citing works

The physiological regulation of uncoupling proteins

Nicholls, D. G. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.02.005 · Cited by 183 · see citing works

Uncoupling proteins: A role in protection against reactive oxygen species—or not?

Cannon, B., Shabalina, I. G., Kramarova, T. V., Petrovic, N., & Nedergaard, J. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.05.016 · Cited by 182 · see citing works

Type 1 Diabetic Akita Mouse Hearts Are Insulin Sensitive but Manifest Structurally Abnormal Mitochondria That Remain Coupled Despite Increased Uncoupling Protein 3

Bugger, H., Boudina, S., Hu, X. X., Tuinei, J., Zaha, V. G., Theobald, H. A., Yun, U. J., McQueen, A. P., Wayment, B., Litwin, S. E., et al. (2008) · Diabetes · doi:10.2337/db08-0079 · Cited by 182 · see citing works

Respiration uncoupling and metabolism in the control of energy expenditure

Ricquier, D. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2004408 · Cited by 175 · see citing works

Glutathionylation Acts as a Control Switch for Uncoupling Proteins UCP2 and UCP3

Mailloux, R. J., Seifert, E. L., Bouillaud, F., Aguer, C., Collins, S., & Harper, M.-E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.240242 · Cited by 174 · see citing works

Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria

Bevilacqua, L., Ramsey, J. J., Hagopian, K., Weindruch, R., & Harper, M.-E. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00435.2004 · Cited by 172 · see citing works

Mitochondrial uncoupling and lifespan

Mookerjee, S. A., Divakaruni, A. S., Jastroch, M., & Brand, M. D. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.03.010 · Cited by 169 · see citing works

The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation

Samudio, I., Fiegl, M., McQueen, T., Clise-Dwyer, K., & Andreeff, M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0555 · Cited by 168 · see citing works

High-fat diet, muscular lipotoxicity and insulin resistance

Schrauwen, P. (2007) · Proceedings of the Nutrition Society · doi:10.1017/s0029665107005277 · Cited by 153 · see citing works

UCP2, not a physiologically relevant uncoupler but a glucose sparing switch impacting ROS production and glucose sensing

Bouillaud, F. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.01.003 · Cited by 146 · see citing works

The regulation and turnover of mitochondrial uncoupling proteins

Azzu, V., Jastroch, M., Divakaruni, A. S., & Brand, M. D. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.02.035 · Cited by 146 · see citing works

β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

Robson-Doucette, C. A., Sultan, S., Allister, E. M., Wikstrom, J. D., Koshkin, V., Bhattacharjee, A., Prentice, K. J., Sereda, S. B., Shirihai, O. S., & Wheeler, M. B. (2011) · Diabetes · doi:10.2337/db11-0132 · Cited by 136 · see citing works

Sepsis induces brain mitochondrial dysfunction.

d’Avila, J. D. C. P., Santiago, A. P. S. A., Amâncio, R. T., Galina, A., Oliveira, M. F., & Bozza, F. A. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181760c4b · Cited by 134 · see citing works

Mitochondrial nitroalkene formation and mild uncoupling in ischaemic preconditioning. Implications for cardioprotection

Nadtochiy, S. M., Baker, P. R. S., Freeman, B. A., & Brookes, P. S. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvn323 · Cited by 131 · see citing works

Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3

Talbot, D. A., Lambert, A. J., & Brand, M. D. (2004) · FEBS Letters · doi:10.1016/s0014-5793(03)01386-3 · Cited by 131 · see citing works

Mechanisms of Sudden Cardiac Death: Oxidants and Metabolism

Yang, K.-C., Kyle, J. W., Makielski, J. C., & Dudley, S. C. (2015) · Circulation Research · doi:10.1161/circresaha.116.304691 · Cited by 127 · see citing works

The efficiency of cellular energy transduction and its implications for obesity

Harper, M.-E., Green, K., & Brand, M. D. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155357 · Cited by 121 · see citing works

Nitroxia: The pathological consequence of dysfunction in the nitric oxide–cytochrome c oxidase signaling pathway

Shiva, S., Oh, J.-Y., Landar, A. L., Ulasova, E., Venkatraman, A., Bailey, S. M., & Darley-Usmar, V. M. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.037 · Cited by 112 · see citing works

Lifespan and mitochondrial control of neurodegeneration

Wright, A. F., Jacobson, S. G., Cideciyan, A. V., Roman, A. J., Shu, X., Vlachantoni, D., McInnes, R. R., & Riemersma, R. A. (2004) · Nature Genetics · doi:10.1038/ng1448 · Cited by 111 · see citing works

Essential Role for Uncoupling Protein-3 in Mitochondrial Adaptation to Fasting but Not in Fatty Acid Oxidation or Fatty Acid Anion Export

Seifert, E. L., Bézaire, V., Estey, C., & Harper, M.-E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803871200 · Cited by 104 · see citing works

Reduction of body weight by dietary garlic is associated with an increase in uncoupling protein mRNA expression and activation of AMP-activated protein kinase in diet-induced obese mice

Lee, M.-S., Kim, I.-H., Kim, C.-T., & Kim, Y. (2011) · The Journal of Nutrition · doi:10.3945/jn.111.146050 · Cited by 100 · see citing works

Coenzyme Q10 Depletion in Medical and Neuropsychiatric Disorders: Potential Repercussions and Therapeutic Implications

Morris, G., Anderson, G., Berk, M., & Maes, M. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8477-8 · Cited by 96 · see citing works

Reactive oxygen species and uncoupling protein 2 in pancreatic <i>β</i> ‐cell function

Pi, J., & Collins, S. (2010) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01269.x · Cited by 91 · see citing works

Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1

Smith, B. K., Ford, R. J., Desjardins, E. M., Green, A. E., Hughes, M. C., Houde, V. P., Day, E. A., Marcinko, K., Crane, J. D., Mottillo, E. P., et al. (2016) · Diabetes · doi:10.2337/db16-0564 · Cited by 79 · see citing works

Peroxisome proliferator-activated receptor-γ coactivator-1 and insulin resistance: acute effect of fatty acids

Hoeks, J., Hesselink, M. K. C., Russell, A. P., Mensink, M., Saris, W. H. M., Mensink, R. P., & Schrauwen, P. (2006) · Diabetologia · doi:10.1007/s00125-006-0369-2 · Cited by 74 · see citing works

Uncoupling Proteins: Role in Insulin Resistance and Insulin Insufficiency

B.Chan, C., & Harper, M.-E. (2006) · Current Diabetes Reviews · doi:10.2174/157339906777950660 · Cited by 71 · see citing works

Long-term high-fat feeding induces greater fat storage in mice lacking UCP3

Costford, S. R., Chaudhry, S. N., Crawford, S. A., Salkhordeh, M., & Harper, M.-E. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00779.2007 · Cited by 64 · see citing works

Age and sex-related changes in rat brain mitochondrial oxidative status

Guevara, R., Gianotti, M., Oliver, J., & Roca, P. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.08.003 · Cited by 63 · see citing works

Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose

Mozo, J., Ferry, G., Studeny, A., Pecqueur, C., Rodriguez, M., Boutin, J. A., & Bouillaud, F. (2006) · Biochemical Journal · doi:10.1042/bj20050494 · Cited by 52 · see citing works

The electrophile responsive proteome: Integrating proteomics and lipidomics with cellular function

Higdon, A. N., Landar, A., Barnes, S., & Darley-Usmar, V. M. (2012) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2012.4523 · Cited by 51 · see citing works

High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation

Azzu, V., Parker, N., & Brand, M. D. (2008) · Biochemical Journal · doi:10.1042/bj20080321 · Cited by 52 · see citing works

Role of lipid-derived mediators in skeletal muscle insulin resistance

Taube, A., Eckardt, K., & Eckel, J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00241.2009 · Cited by 40 · see citing works

Identification of serine phosphorylation in mitochondrial uncoupling protein 1

Carroll, A. M., Porter, R. K., & Morrice, N. A. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.04.030 · Cited by 26 · see citing works

The Ghost Boulevard

Börén, T. (2021) · Nordisk øst-forum/Nordisk østforum · doi:10.23865/noros.v35.2691

Plate 13: [Bounded by Rockaway Beach Boulevard, Averne Boulevard,... (Atlantic Ocean, Jamaica Bay), Eldert Avenue, Rockaway Beach Boulevard, Eastern Avenue, Triton Avenue and Tenth Avenue.]

Wolverton, C. (1891) · New York Public Library eBooks

Presentation and explanation of a system model of human behavior in urban areas (Case Study: Sajjad Boulevard and Imamieh Boulevard in Mashhad)

Abad, H. K. K., & nejad, H. H. (2019) · International Academic Journal of Social Sciences · doi:10.9756/iajss/v6i1/1910001

Reinventing spaces/reoccuring places : a re-examination of Grand Boulevard at Boulevard Park, North Vancouver

Suen, J. (2009) · cIRcle (University of British Columbia) · doi:10.14288/1.0099761

Cultural Resources Investigations for Alignment and Environmental Studies, Halfway Boulevard Extended and Newgate Boulevard (PUR-577), Washington County, Maryland

Fehr, A. L., Kuranda, K. M., Williams, M. R., et al. (1997)