The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
4‐Hydroxynonenal: A membrane lipid oxidation product of medicinal interest
Abstract
A comprehensive focus on 4‐hydroxynonenal (HNE) as candidate molecule in a variety of pathophysiological conditions occurring in humans is here provided. Despite an active, now well characterized, metabolism in most cells and tissues, HNE can be easily detected and quantified by means of several methods, although with different sensitivity. Measurements of HNE and/or stable metabolites in biological fluids are already applied as lipid peroxidation/oxidative stress markers in a huge number of human disease processes, often sustained by inflammatory reactions. A primary involvement of this aldehydic product of membrane lipid oxidation in inflammation‐related events, as well as in regulation of cell proliferation and growth, in necrotic or apoptotic cell death, appears supported by its marked ability to modulate several major pathways of cell signaling and, consequently, gene expression. The actual knowledge of HNE reactivity, metabolism, signaling and modulatory effect in the various human organs should provide a solid background to the investigation of the aldehyde's contribution to the pathogenesis of human major chronic diseases and would likely promote advanced and oriented applications not only in diagnosis and prevention but also in molecular treatment of human diseases. © 2007 Wiley Periodicals, Inc. Med Res Rev, 28, No. 4, 569–631, 2008
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Cites
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Cantley, L. C. (2002) · Science · doi:10.1126/science.296.5573.1655 · Cited by 5,621
Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.
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“Oxidative stress and lipid peroxidation are likely involved also in the pathogenesis of diseases characterized by Lewy body formation.(315,328,329) With regard to HNE, HNE-lysine adducts were histochemically detected in autopsy brain tissue from both PD and diffuse Lewy body disease, within the Lewy bodies themselves.”
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Evidence of Oxidative Stress in the Neocortex in Incidental Lewy Body Disease
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Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes
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Assessment of antioxidant capacity in vitro and in vivo
Niki, E. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.016 · Cited by 873
Biomarkers of Oxidative Stress and Antioxidant Defense
Demirci-Çekiç, S., Özkan, G., Avan, A. N., Uzunboy, S., Çapanoğlu, E., & Apak, R. (2022) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.114477 · Cited by 587
Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance
Dalleau, S., Baradat, M., Guéraud, F., & Huc, L. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.138 · Cited by 580
Biomarkers of lipid peroxidation in clinical material
Niki, E. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.03.020 · Cited by 297
An overview of the chemistry and biology of reactive aldehydes
Fritz, K. S., & Petersen, D. R. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.06.025 · Cited by 237
Metadata
- Authors
- Poli, G., Schaur, R. J., Siems, W. G., & Leonarduzzi, G.
- Venue
- Medicinal Research Reviews
- Publisher
- Wiley
- Published
- 2007-12-03
- Volume
- 28
- Issue
- 4
- Pages
- 569-631
- ISSN
- 0198-6325 (ISSN-L)
- 1098-1128
- OpenAlex
- W2134240491
- Cited by
- 433
- References
- 11
- FWCI
- 14.23
- Type
- journal article
- Language
- en
- Open access
- closed
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