Cited by 104Barrier Structure and Function StudiesDrug Transport and Resistance MechanismsGastrointestinal motility and disorders

The blood-brain barrier: connecting the gut and the brain

Open access
Banks, William A.·2008·Regulatory Peptides

Abstract

The BBB prevents the unrestricted exchange of substances between the central nervous system (CNS) and the blood. The blood-brain barrier (BBB) also conveys information between the CNS and the gastrointestinal (GI) tract through several mechanisms. Here, we review three of those mechanisms. First, the BBB selectively transports some peptides and regulatory proteins in the blood-to-brain or the brain-to-blood direction. The ability of GI hormones to affect functions of the BBB, as illustrated by the ability of insulin to alter the BBB transport of amino acids and drugs, represents a second mechanism. A third mechanism is the ability of GI hormones to affect the secretion by the BBB of substances that themselves affect feeding and appetite, such as nitric oxide and cytokines. By these and other mechanisms, the BBB regulates communications between the CNS and GI tract.

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Crossref · 10.1016/j.regpep.2007.08.027

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  • Peripherally produced ghrelin exerts appetite-inducing effects centrally after passing through the BBB.

    “Peripherally produced ghrelin exerts its appetite-inducing effects centrally after passing through the BBB [112, 302-304].”

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Authors
Banks, W. A.
Affiliations
St. Louis VA Medical Center (US)
Corresponding author
Banks, William A.
Venue
Regulatory Peptides
Publisher
Elsevier BV
Published
2008-08
Volume
149
Issue
1-3
Pages
11-14
ISSN
0167-0115 (ISSN-L)
OpenAlex
W2058610680
Cited by
104
References
46
Citations by year
2026: 3 · 2025: 7 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 9 · 2016: 2 · 2015: 7 · 2014: 9 · 2013: 5 · 2012: 6
FWCI
0.72
Type
journal article
Language
en
Open access
Locations
  • Regulatory Peptides (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (R01AG029839)
  • National Institute of Neurological Disorders and Stroke (R01NS050547)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
blood-brain barrier, gut-brain axis, gastrointestinal hormones, insulin, amino acid transport, drug transport, nitric oxide, cytokines, appetite regulation, feeding behavior, peptide transport
MeSH terms
Animals, Biological Transport, Blood-Brain Barrier, Brain, Central Nervous System, Humans, Insulin, Models, Biological, Leptin, Peptide Hormones, Gastrointestinal Tract, Ghrelin

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