Cited by 124Regulation of Appetite and ObesityDiabetes Treatment and ManagementAdipokines, Inflammation, and Metabolic Diseases

Glucagon-Like Peptide 1 Interacts with Ghrelin and Leptin to Regulate Glucose Metabolism and Food Intake through Vagal Afferent Neuron Signaling ,

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Ronveaux, Charlotte C, Tomé, Daniel, Raybould, Helen E·2015·The Journal of Nutrition

Abstract

Emerging evidence has suggested a possible physiologic role for peripheral glucagon-like peptide 1 (GLP-1) in regulating glucose metabolism and food intake. The likely site of action of GLP-1 is on vagal afferent neurons (VANs). The vagal afferent pathway is the major neural pathway by which information about ingested nutrients reaches the central nervous system and influences feeding behavior. Peripheral GLP-1 acts on VANs to inhibit food intake. The mechanism of the GLP-1 receptor (GLP-1R) is unlike other gut-derived receptors; GLP-1Rs change their cellular localization according to feeding status rather than their protein concentrations. It is possible that several gut peptides are involved in mediating GLP-1R translocation. The mechanism of peripheral GLP-1R translocation still needs to be elucidated. We review data supporting the role of peripheral GLP-1 acting on VANs in influencing glucose homeostasis and feeding behavior. We highlight evidence demonstrating that GLP-1 interacts with ghrelin and leptin to induce satiation. Our aim was to understand the mechanism of peripheral GLP-1 in the development of noninvasive antiobesity treatments.

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  • GLP-1 and GIP work synergistically to potentiate glucose-stimulated insulin secretion by pancreatic β-cells.

    “GLP‐1 and GIP work synergistically to potentiate glucose‐stimulated insulin secretion by pancreatic β‐cells 21.”
  • A major target for gut-derived hormones is the vagal afferent neurons (VANs).

    “A major target for gut‐derived hormones is the vagal afferent neurons (VANs) 21.”
  • Ghrelin attenuates insulin production and increases blood glucose concentration by promoting intracellular localization of pancreatic β-cell GLP-1R under fasting conditions, thus counteracting GLP-1 signaling.

    “Ghrelin attenuates insulin production and increases blood glucose concentration by promoting the intracellular localization of the pancreatic β‐cell GLP‐1R under fasting conditions, thus counteracting GLP‐1 signaling 21.”

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4 of the 122 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. Dunphy JL, Taylor RG, Fuller PJ. Tissue distribution of rat glucagon receptor and GLP-1 receptor gene expression. Mol Cell Endocrinol 1998;141:179-86.
  2. Doyle ME. Mechanisms of Action of GLP-1 in the Pancreas. Pharma- cotherapy 2007;113:546-93.
  3. Meeran K, OÕShea D, Edwards CM, Turton MD, Heath MM, Gunn I, Abusnana S, Rossi M, Small CJ, Goldstone AP, et al. Repeated intracerebroventricular administration of glucagon-like peptide-1-(7- 36) amide or exendin-(9-39) alters body weight in the rat. Endocri- nology 1999;140:244-50.

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Authors
Ronveaux, C. C., Tomé, D., & Raybould, H. E.
Affiliations
  • AgroParisTech (FR)
  • University of California, Davis (US)
Corresponding author
Raybould, Helen E
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2015-04
Volume
145
Issue
4
Pages
672-680
ISSN
0022-3166 (ISSN-L)
OpenAlex
W2049375442
Cited by
124
References
122
Citations by year
2026: 12 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 12 · 2020: 10 · 2019: 12 · 2018: 17 · 2017: 12 · 2016: 9 · 2015: 7
FWCI
1.62
Type
journal article
Language
en
Open access
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK041004)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
glucagon-like peptide-1, GLP-1 receptor, vagal afferent neurons, ghrelin, leptin, glucose metabolism, food intake regulation, satiation, glucose homeostasis, receptor translocation, gut-brain signaling
MeSH terms
Glucagon-Like Peptide-1 Receptor, Animals, Blood Glucose, Eating, Humans, Neurons, Afferent, Satiation, Signal Transduction, Receptors, Glucagon, Leptin, Gastrointestinal Tract, Glucagon-Like Peptide 1, Ghrelin

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