The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Hydrocarbons (jet fuel JP-8) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations
Open accessAbstract
Environmental compounds have been shown to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a hydrocarbon mixture involving jet fuel (JP-8) promotes epigenetic transgenerational inheritance of disease. Gestating F0 generation female rats were transiently exposed during the fetal gonadal development period. The direct exposure F1 generation had an increased incidence of kidney abnormalities in both females and males, prostate and pubertal abnormalities in males, and primordial follicle loss and polycystic ovarian disease in females. The first transgenerational generation is the F3 generation, and the jet fuel lineage had an increased incidence of primordial follicle loss and polycystic ovarian disease in females, and obesity in both females and males. Analysis of the jet fuel lineage F3 generation sperm epigenome identified 33 differential DNA methylation regions, termed epimutations. Observations demonstrate hydrocarbons can promote epigenetic transgenerational inheritance of disease and sperm epimutations, potential biomarkers for ancestral exposures.
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Cites
Environmental epigenomics and disease susceptibility
Jirtle, R. L., & Skinner, M. K. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2045 · Cited by 2,492
Self-citationTransgenerational epigenetic inheritance of longevity in Caenorhabditis elegans
Greer, E. L., Maures, T. J., Ucar, D., Hauswirth, A. G., Mancini, E., Lim, J. P., Benayoun, B. A., Shi, Y., & Brunet, A. (2011) · Nature · doi:10.1038/nature10572 · Cited by 660
Jacquemont, S., Curie, A., des Portes, V., Torrioli, M. G., Berry-Kravis, E., Hagerman, R. J., Ramos, F. J., Cornish, K., He, Y., Paulding, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001708 · Cited by 609
Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability
(2011) · Epigenetics · doi:10.4161/epi.6.7.16537 · Cited by 368
Self-citationXu, N., Kwon, S., Abbott, D. H., Geller, D. H., Dumesic, D. A., Azziz, R., Guo, X., & Goodarzi, M. O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027286 · Cited by 155
Cited by
EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Endocrine disruptors and obesity
Heindel, J. J., Newbold, R., & Schug, T. T. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.163 · Cited by 451
Heindel, J. J., & Vandenberg, L. N. (2015) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000191 · Cited by 439
A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line
Soubry, A., Hoyo, C., Jirtle, R. L., & Murphy, S. K. (2014) · BioEssays · doi:10.1002/bies.201300113 · Cited by 354
Epigenetics, plasticity, and evolution: How do we link epigenetic change to phenotype?
Duncan, E. J., Gluckman, P. D., & Dearden, P. K. (2014) · Journal of Experimental Zoology Part B: Molecular and Developmental Evolution · doi:10.1002/jez.b.22571 · Cited by 318
Metadata
- Authors
- Tracey, R., Manikkam, M., Guerrero-Bosagna, C., & Skinner, M. K.
- Venue
- Reproductive Toxicology
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 36
- Pages
- 104-116
- ISSN
- 0890-6238 (ISSN-L)
- OpenAlex
- W2143085832
- Cited by
- 223
- References
- 5
- FWCI
- 12.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Tracey, R., Manikkam, M., Guerrero-Bosagna, C., & Skinner, M. K. (2013). Hydrocarbons (jet fuel JP-8) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations. Reproductive Toxicology. https://doi.org/10.1016/j.reprotox.2012.11.011
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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