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Cited by 439Birth, Development, and HealthEpigenetics and DNA MethylationHealth, Environment, Cognitive Aging

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Developmental origins of health and disease: a paradigm for understanding disease cause and prevention

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Heindel, Jerrold J., Vandenberg, Laura N.·2015·Current Opinion in Pediatrics
DOI 10.1097/mop.0000000000000191PMC PMC4535724
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Abstract

PURPOSE OF REVIEW: Although diseases may appear clinically throughout the lifespan, it is clear that many diseases have origins during development. Altered nutrition, as well as exposure to environmental chemicals, drugs, infections, or stress during specific times of development, can lead to functional changes in tissues, predisposing those tissues to diseases that manifest later in life. This review will focus on the role of altered nutrition and exposures to environmental chemicals during development in the role of disease and dysfunction. RECENT FINDINGS: The effects of altered nutrition or exposure to environmental chemicals during development are likely because of altered programming of epigenetic marks, which persist across the lifespan. Indeed some changes can be transmitted to future generations. SUMMARY: The evidence in support of the developmental origins of the health and disease paradigm is sufficiently robust and repeatable across species, including humans, to suggest a need for greater emphasis in the clinical area. As a result of these data, obesity, diabetes, cardiovascular morbidity, and neuropsychiatric diseases can all be considered pediatric diseases. Disease prevention must start with improved nutrition and reduced exposure to environmental chemicals during development.

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Metadata

Authors
Heindel, J. J., & Vandenberg, L. N.
Affiliations
University of Massachusetts Amherst (US)
Corresponding author
Heindel, Jerrold J.
ORCID
Venue
Current Opinion in Pediatrics
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-04
Volume
27
Issue
2
Pages
248-253
ISSN
1040-8703 (ISSN-L)
DOI
10.1097/mop.0000000000000191
PMC
PMC4535724
OpenAlex
W2026835968
Cited by
439
References
5
Citations by year
2026: 39 · 2025: 39 · 2024: 41 · 2023: 37 · 2022: 41 · 2021: 85 · 2020: 50 · 2019: 32 · 2018: 39 · 2017: 18 · 2016: 10 · 2015: 8
FWCI
3.81
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (Z99-ES999999)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords
developmental origins of health and disease, fetal programming, epigenetic modifications, environmental chemical exposure, obesity, diabetes mellitus, cardiovascular disease, neuropsychiatric disorders, disease prevention, childhood diseases
MeSH terms
Child, Environmental Exposure, Environmental Pollutants, Female, Humans, Male, Nutritional Physiological Phenomena, Pregnancy, Prenatal Exposure Delayed Effects, Public Health, Epigenomics, Gene-Environment Interaction

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