Cited by 2,018Effects and risks of endocrine disrupting chemicalsToxic Organic Pollutants ImpactPhytoestrogen effects and research

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Bisphenol A and human health: A review of the literature

Rochester, Johanna R.·2013·Reproductive Toxicology

DOI 10.1016/j.reprotox.2013.08.008

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Abstract

There is growing evidence that bisphenol A (BPA) may adversely affect humans. BPA is an endocrine disruptor that has been shown to be harmful in laboratory animal studies. Until recently, there were relatively few epidemiological studies examining the relationship between BPA and health effects in humans. However, in the last year, the number of these studies has more than doubled. A comprehensive literature search found 91 studies linking BPA to human health; 53 published within the last year. This review outlines this body of literature, showing associations between BPA exposure and adverse perinatal, childhood, and adult health outcomes, including reproductive and developmental effects, metabolic disease, and other health effects. These studies encompass both prenatal and postnatal exposures, and include several study designs and population types. While it is difficult to make causal links with epidemiological studies, the growing human literature correlating environmental BPA exposure to adverse effects in humans, along with laboratory studies in many species including primates, provides increasing support that environmental BPA exposure can be harmful to humans, especially in regards to behavioral and other effects in children.

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Authors: Rochester, J. R.
Corresponding author: Rochester, Johanna R.
ORCID: Rochester, Johanna R.
Venue: Reproductive Toxicology
Publisher: Elsevier BV
Published: 2013-12
Volume: 42
Pages: 132-155
ISSN: 0890-6238 (ISSN-L)
DOI: 10.1016/j.reprotox.2013.08.008
OpenAlex: W2162830803
Cited by: 2,018
References: 203
Citations by year: 2026: 159 · 2025: 146 · 2024: 177 · 2023: 142 · 2022: 187 · 2021: 188 · 2020: 191 · 2019: 188 · 2018: 164 · 2017: 146 · 2016: 141 · 2015: 112 · 2014: 68 · 2013: 6
FWCI: 12.79
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Reproductive Toxicology (publishedVersion)
PubMed (publishedVersion)
Funders: The Arkansas Community Foundation
The Winslow Foundation
The Johnson Family Foundation
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
Keywords: bisphenol A, endocrine disruptors, human health effects, prenatal exposure, postnatal exposure, reproductive effects, developmental effects, metabolic disorders, child health outcomes, perinatal outcomes, environmental exposure
MeSH terms: Bisphenol A Compounds, Animals, Benzhydryl Compounds, Humans, Metabolic Diseases, Phenols, Reproduction, Endocrine Disruptors

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Bisphenol A and human health: A review of the literature

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