Cited by 398Cardiovascular and exercise physiologySports Performance and TrainingNeuroscience of respiration and sleep

Consequences of exercise-induced respiratory muscle work

Dempsey, Jerome A., Romer, Lee, Rodman, Joshua, Miller, Jordan, Smith, Curtis·2006·Respiratory Physiology & Neurobiology

Abstract

We briefly review the evidence for a hypothesis, which links the ventilatory response to heavy intensity, sustained exercise-to-exercise performance limitation in health. A key step in this linkage is a respiratory muscle fatigue-induced metaboreflex, which increases sympathetic vasoconstrictor outflow, causing reduced blood flow to locomotor muscles and locomotor muscle fatigue. In turn, the limb fatigue comprises an important dual contribution to both peripheral and central fatigue mechanisms, which contribute to limiting exercise performance. Clinical implications for respiratory limitations to exercise in patients with chronic obstructive lung disease (COPD) and chronic heart failure (CHF) are discussed and key unresolved problems are outlined.

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Crossref · 10.1016/j.resp.2005.12.015

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Authors
Dempsey, J. A., Romer, L., Rodman, J., Miller, J., & Smith, C.
Affiliations
University of Wisconsin–Madison (US)
Corresponding author
Dempsey, Jerome A.
Venue
Respiratory Physiology & Neurobiology
Publisher
Elsevier BV
Published
2006-04
Volume
151
Issue
2-3
Pages
242-250
ISSN
1569-9048 (ISSN-L)
OpenAlex
W1973218442
Cited by
398
References
35
Citations by year
2026: 23 · 2025: 22 · 2024: 19 · 2023: 18 · 2022: 28 · 2021: 23 · 2020: 34 · 2019: 26 · 2018: 26 · 2017: 22 · 2016: 14 · 2015: 18 · 2014: 14 · 2013: 9 · 2012: 22
FWCI
3.84
Type
journal article
Language
en
Open access
closed
Locations
  • Respiratory Physiology & Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Heart Association
  • National Heart, Lung, and Blood Institute
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
muscle metaboreflex, ventilatory response, central fatigue, peripheral fatigue, sympathetic vasoconstriction, chronic obstructive pulmonary disease, chronic heart failure, respiratory muscle work
MeSH terms
Animals, Humans, Models, Biological, Physical Endurance, Respiratory Muscles, Exercise, Muscle, Skeletal, Muscle Fatigue

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