Cited by 321Schizophrenia research and treatmentNeural dynamics and brain functionNeural and Behavioral Psychology Studies

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Mismatch negativity potentials and cognitive impairment in schizophrenia

Baldeweg, Torsten, Klugman, Anthony, Gruzelier, John, Hirsch, Steven R·2004·Schizophrenia Research

DOI 10.1016/j.schres.2003.09.009

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Abstract

Cognitive impairment in schizophrenia is an important predictor of clinical and social outcome. In this preliminary study, the correlation between cognitive status and deficits in mismatch negativity (MMN) generation was explored. The MMN response to tone duration deviants was recorded using a new stimulation protocol with continuously changing ('roving') standard stimuli in order to measure the effect of standard repetitions on MMN (memory trace effect). Cognitive status of the patient group (n=28) was assessed using neuropsychological screening. Healthy participants (n=20) served as age-matched comparison group. In patients, MMN amplitude in frontal electrodes as well as the MMN memory trace effect was diminished compared to controls. While both measures were inversely related to patient's age and disease severity, only the MMN memory trace effect was robustly correlated with the degree of neuropsychological impairment. This suggests that ERP measures of auditory system adaptability more appropriately characterise the pathophysiological processes underlying cognitive impairment in schizophrenia than static measures of ERP magnitude.

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Background
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“Accordingly, several studies using electroencephalography (EEG) have shown the existence of a repetition positivity (RP), a combined modulation of the P50, N1 and P2 event-related potentials (ERPs) which is positively related to MMN amplitude and that represents a direct signature of auditory sensory memory (Baldeweg…”
Trial-by-trial surprise-decoding model for visual and auditory binary oddball tasks
Modirshanechi, A., Kiani, M. M., & Aghajan, H. K. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.04.028 · Cited by 21
A Critical Review of the Deviance Detection Theory of Mismatch Negativity
O’Reilly, J. A., & O’Reilly, A. (2021) · NeuroSci · doi:10.3390/neurosci2020011 · Cited by 21
“A slightly different control sequence used in MMN studies is known as the roving oddball paradigm [9,72].”
Method
Current challenges and possible future developments in personalized psychiatry with an emphasis on psychotic disorders
Levchenko, А., Nurgaliev, T., Kanapin, A. A., Samsonova, A. A., & Gainetdinov, R. R. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03990 · Cited by 20
“MMN is associated with poor functioning of patients in the community [129, 130, 131, 132, 133, 134] and reduced cognitive function in patients and healthy subjects [131, 132, 134, 135, 136, 137, 138].”
Background
Longitudinal relationships between mismatch negativity, cognitive performance, and real-world functioning in early psychosis
Higgins, A., Lewandowski, K. E., Liukasemsarn, S., & Hall, M. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.01.009 · Cited by 21
“Accumulating evidence shows that MMN abnormalities in people with SZ and related disorders are tied to downstream functional deficits including measures of social skills, work, independence in daily living, and global ratings of psychosocial functioning (Baldeweg et al., 2004; Light et al., 2007; Naatanen et al., 2011…”
Background
Responses to deviants are modulated by subthreshold variability of the standard
Daikhin, L., & Ahissar, M. (2011) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01274.x · Cited by 22
Establishing the functional connectivity of the frontotemporal network in pre-attentive change detection with Transcranial Magnetic Stimulation and event-related optical signal
Tse, C., Yip, L., Lui, T. K., Xiao, X.-Z., Wang, Y., Chu, C. W., Parks, N. A., Chan, S. S. M., & Neggers, S. F. W. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.06.053 · Cited by 19
“Previous studies (Baldeweg et al., 2004; Bendixen et al., 2007; Bendixen and Schr€ oger, 2008; Haenschel et al., 2005; Vossel et al., 2011; Winkler et al., 1996) demonstrated larger MMN amplitudes for deviants preceded by longer standard trains (i.”
BackgroundResult
A multimodal cortical network of sensory expectation violation revealed by fMRI
Grundei, M., Schmidt, T. T., & Blankenburg, F. (2023) · Human Brain Mapping · doi:10.1002/hbm.26482 · Cited by 19
“The paradigm allows to study responses to rare stimulus transitions independent of their equiprobable features (Baldeweg et al., 2004; Cowan et al., 1993; Garrido et al., 2008).”
Background
Functional features of crossmodal mismatch responses
Zhao, C., Valentini, E., & Hu, L. (2014) · Experimental Brain Research · doi:10.1007/s00221-014-4141-4 · Cited by 19
A comparative study on long-term evoked auditory and visual potential responses between Schizophrenic patients and normal subjects
Huang, M., Chou, F. H., Lo, P.-Y., & Cheng, K. (2011) · BMC Psychiatry · doi:10.1186/1471-244x-11-74 · Cited by 21
“Recent studies suggest that ERP measurement of auditory system adaptability characterize the pathophysiological process underlying the cognitive impairment more appropriately in schizophrenia than static measurement of ERP magnitude [26].”
Background
Visual mismatch negativity and stimulus-specific adaptation: the role of stimulus complexity
Kojouharova, P., File, D., Sulykos, I., & Czigler, I. (2019) · Experimental Brain Research · doi:10.1007/s00221-019-05494-2 · Cited by 18
Neurophysiological biomarkers for schizophrenia therapeutics
Light, G. A., Joshi, Y. B., Molina, J. L., Bhakta, S. G., Nungaray, J. A., Cardoso, L., Kotz, J. E., Thomas, M. L., & Swerdlow, N. R. (2020) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2020.100012 · Cited by 18
Forecasting Remission From the Psychosis Risk Syndrome With Mismatch Negativity and P300: Potentials and Pitfalls
Hamilton, H., Roach, B. J., & Mathalon, D. H. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.10.010 · Cited by 18
Prediction and Expectation
Schubotz, R. I. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397025-1.00247-5 · Cited by 19
Standard Tone Stability as a Manipulation of Precision in the Oddball Paradigm: Modulation of Prediction Error Responses to Fixed-Probability Deviants
SanMiguel, I., Costa‐Faidella, J., Lugo, Z., Vilella, E., & Escera, C. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.734200 · Cited by 16
Mismatch negativity amplitude in first-degree relatives of individuals with psychotic disorders: Links with cognition and schizotypy
Donaldson, K. R., Larsen, E. M., Jonas, K. G., Tramazzo, S., Perlman, G., Foti, D., Mohanty, A., & Kotov, R. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.10.006 · Cited by 16
A preliminary study to investigate resting state fMRI as a potential group differentiator for schizophrenia
Goswami, S., Beniwal, R. P., Kumar, M., Triptish Bhatia, A., Gur, R. E., Gur, R. C., Khushu, S., & Deshpande, S. N. (2020) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2020.102095 · Cited by 17
Memory trace dependence on number of stimuli in magnetic mismatch negativity
Matuoka, T., Yabe, H., Asai, R., Hara, E., & Kaneko, S. (2008) · Neuroreport · doi:10.1097/wnr.0b013e328303ba66 · Cited by 16
“[11] recorded the brain response using a similar stimulation protocol.”
Method
Mismatch negativity and clinical trajectories in psychotic disorders: Five-year stability and predictive utility
Donaldson, K. R., Jonas, K. G., Foti, D., Larsen, E. M., Mohanty, A., & Kotov, R. (2022) · Psychological Medicine · doi:10.1017/s0033291722003075 · Cited by 15
“2020), cognitive deficits (Baldeweg et al., 2004; Donaldson et al., 2020, 2021; Hermens et al., 2010; Kaur et al., 2011; Näätänen et al., 2011), and poor functioning (Donaldson et al.”
Background
Mismatch negativity and cognitive performance in the course of schizophrenia
Hirt, V., Schubring, D., Schalinski, I., & Rockstroh, B. S. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2019.01.006 · Cited by 18
Temporal and Spectral Properties of the Auditory Mismatch Negativity and P3a Responses in Schizophrenia
Lundin, N. B., Burroughs, L. P., Kieffaber, P. D., Morales, J. J., O’Donnell, B. F., & Hetrick, W. P. (2022) · Clinical EEG and Neuroscience · doi:10.1177/15500594221089367 · Cited by 15
Auditory, Visual, and Cross-Modal Mismatch Negativities in the Rat Auditory and Visual Cortices
Shiramatsu, T. I., Mori, K., Ishizu, K., & Takahashi, H. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.721476 · Cited by 17
Cortical mapping of mismatch responses to independent acoustic features
An, H., Auksztulewicz, R., Kang, H., & Schnupp, J. W. H. (2020) · Hearing Research · doi:10.1016/j.heares.2020.107894 · Cited by 13
Effect of Tandospirone on Mismatch Negativity and Cognitive Performance in Schizophrenia
Higuchi, Y., Sumiyoshi, T., Kawasaki, Y., Ito, T., Seo, T., & Suzuki, M. (2010) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181faa57d · Cited by 14
Attenuated mismatch negativity in patients with first-episode antipsychotic-naive schizophrenia using a source-resolved method
Randau, M., Oranje, B., Miyakoshi, M., Makeig, S., Fagerlund, B., Glenthoj, B. Y., & Bak, N. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101760 · Cited by 14
“In chronic schizophrenia, MMN has been associated with cognitive impairment (Baldeweg et al., 2004), Global Assessment of Functioning (GAF) and patients' level of independence (Light and Braff, 2005), social cognition and functioning (Wynn et al.”
Encoding of deterministic and stochastic auditory rules in the human brain: The mismatch negativity mechanism does not reflect basic probability
Schröger, E., & Roeber, U. (2020) · Hearing Research · doi:10.1016/j.heares.2020.107907 · Cited by 14
Increasing the Excitatory Drive Rescues Excitatory/Inhibitory Imbalance and Mismatch Negativity Deficit Caused by Parvalbumin Specific GluA1 Deletion
Chen-Engerer, H.-J., Jaeger, S., Bondarenko, R., Sprengel, R., Hengerer, B., Rosenbrock, H., Mack, V., & Schuelert, N. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.06.027 · Cited by 13
“We used a MMN protocol (Baldeweg et al., 2004; Wynn et al., 2010; Fitzgerald and Todd, 2020) to evaluate the integrity of deviance detection which is impaired in schizophrenia patients and linked to cognitive dysfunction (Baldeweg et al.”
Influential
Temporal dynamics of contingency extraction from tonal and verbal auditory sequences
Bendixen, A., Schwartze, M., & Kotz, S. A. (2014) · Brain and Language · doi:10.1016/j.bandl.2014.11.009 · Cited by 13
The auditory N1 suppression rebounds as prediction persists over time
Hsu, Y., Hämäläinen, J. A., & Waszak, F. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.02.019 · Cited by 13
“…(see Näätänen and Picton, 1987 for a review), with one interpretation of the effect being related to repetition positivity, a frontocentral slow positive wave at 50-250 ms increasing with the number of stimulus repetition (Baldeweg et al., 2004; Haenschel et al., 2005; Costa-Faidella et al., 2011).”
Mismatch Negativity in Rat Auditory Cortex Represents the Empirical Salience of Sounds
Shiramatsu, T. I., & Takahashi, H. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00924 · Cited by 15
“Such future studies will link the impaired MMN as described in the glutamate hypothesis (Shelley et al., 1991; Baldeweg et al., 2004; Brockhaus-Dumke et al., 2005; Light and Braff, 2005) and impaired salience processing as discussed in the dopamine hypothesis of schizophrenia (Kapur, 2003; Nelson et al.”
Background
How regularity representations of short sound patterns that are based on relative or absolute pitch information establish over time: An EEG study
Bader, M., Schröger, E., & Grimm, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176981 · Cited by 12
Physical but not virtual presence of others potentiates implicit and explicit learning
Sarasso, P., Ronga, I., Fante, E. D., Barbieri, P., Lozzi, I., Rosaia, N., Cicerale, A., Neppi-Mòdona, M., & Sacco, K. (2022) · Scientific Reports · doi:10.1038/s41598-022-25273-4 · Cited by 12
Mismatch negativity in schizophrenia spectrum and bipolar disorders: Group and sex differences and associations with symptom severity
Pentz, A. B., Timpe, C. M. F., Normann, E. M., Slapø, N. B., Melle, I. S., Lagerberg, T. V., Steen, N. E., Westlye, L. T., Jönsson, E. G., Haukvik, U. K., et al. (2023) · Schizophrenia Research · doi:10.1016/j.schres.2023.09.012 · Cited by 13
“The roving paradigm also allows for the quantification of the repetition positivity (RP) and the deviant negativity (DN); these are MMN components which strengthens with increasing number of standard repetitions in HCs, thereby yielding a “memory trace” (Baldeweg, 2006; Baldeweg et al., 2004; Haenschel et al., 2005; M…”
Influential
Effects of awareness and task relevance on neurocomputational models of mismatch negativity generation
Schloßmacher, I., Lucka, F. F., Peters, A., Bruchmann, M., & Straube, T. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119530 · Cited by 11
Shared attention in virtual immersive reality enhances electrophysiological correlates of implicit sensory learning
Sarasso, P., Ronga, I., Piovesan, F., Barbieri, P., Fante, E. D., Luca, D. D., Bechis, L., Osello, A., & Sacco, K. (2024) · Scientific Reports · doi:10.1038/s41598-024-53937-w · Cited by 11
“…paradigms 47 , where the repeated presentation of standard sounds is occasionally interrupted by the occurrence of physically different deviant sounds, in roving paradigms 48,49 different stimuli (high-pitch and low-pitch intervals in our case) can represent both Deviant and Standard stimuli (Fig.”
Background
Computational Modeling of Oddball Sequence Processing Exposes Common and Differential Auditory Network Changes in First-Episode Schizophrenia-Spectrum Disorders and Schizophrenia
Todd, J., Howard, Z. L., Auksztulewicz, R., & Salisbury, D. F. (2022) · Schizophrenia Bulletin · doi:10.1093/schbul/sbac153 · Cited by 11
“In schizophrenia, the reduction in responsiveness to repetitions 14,15 and the sensitization of response to deviations are impaired (for reviews 16–20 ).”
Background
Music playing and memory trace: Evidence from event-related potentials
Kamiyama, K. S., Katahira, K., Abla, D., Hori, K., & Okanoya, K. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.04.007 · Cited by 13
“TheMMNcomponent reflected error-detection activity, and the MMN amplitude was affected by the strength of the auditory representation of standard stimuli (Baldeweg et al., 2004; Haenschel et al., 2005;Winkler et al., 1993).”
Mismatch negativity as a marker of auditory pattern separation
Herman, D., Baker, S., Chow, R., Cazes, J., Alain, C., & Rosenbaum, R. S. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad274 · Cited by 10
Neural Correlates of Automatic and Controlled Auditory Processing in Schizophrenia
Morey, R. A., Mitchell, T. V., Inan, S., Lieberman, J. A., & Belger, A. (2008) · Journal of Neuropsychiatry · doi:10.1176/jnp.2008.20.4.419 · Cited by 10

Authors: Baldeweg, T., Klugman, A., Gruzelier, J., & Hirsch, S. R.
Affiliations: Great Ormond Street Hospital (GB)
Charing Cross Hospital (GB)
Corresponding author: Baldeweg, Torsten
ORCID: Baldeweg, Torsten
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2004-08
Volume: 69
Issue: 2-3
Pages: 203-217
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2003.09.009
OpenAlex: W2142009972
Cited by: 321
References: 64
Citations by year: 2026: 11 · 2025: 9 · 2024: 19 · 2023: 12 · 2022: 17 · 2021: 20 · 2020: 27 · 2019: 27 · 2018: 10 · 2017: 16 · 2016: 10 · 2015: 16 · 2014: 16 · 2013: 16 · 2012: 14
FWCI: 2.65
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Schizophrenia Research (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: mismatch negativity, schizophrenia
MeSH terms: Acoustic Stimulation, Adult, Brain Mapping, Cognition, Cognition Disorders, Contingent Negative Variation, Electroencephalography, Electrooculography, Evoked Potentials, Auditory, Female, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Schizophrenia, Case-Control Studies

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Mismatch negativity potentials and cognitive impairment in schizophrenia

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