The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Mismatch negativity potentials and cognitive impairment in schizophrenia
Abstract
Cognitive impairment in schizophrenia is an important predictor of clinical and social outcome. In this preliminary study, the correlation between cognitive status and deficits in mismatch negativity (MMN) generation was explored. The MMN response to tone duration deviants was recorded using a new stimulation protocol with continuously changing ('roving') standard stimuli in order to measure the effect of standard repetitions on MMN (memory trace effect). Cognitive status of the patient group (n=28) was assessed using neuropsychological screening. Healthy participants (n=20) served as age-matched comparison group. In patients, MMN amplitude in frontal electrodes as well as the MMN memory trace effect was diminished compared to controls. While both measures were inversely related to patient's age and disease severity, only the MMN memory trace effect was robustly correlated with the degree of neuropsychological impairment. This suggests that ERP measures of auditory system adaptability more appropriately characterise the pathophysiological processes underlying cognitive impairment in schizophrenia than static measures of ERP magnitude.
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“They found that healthy controls showed larger MMN amplitudes under longer repetition conditions, while repetition showed no effect on MMN for patients with schizophrenia.”
From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [28]
In the citing paper
“They found that healthy controls showed larger MMN amplitudes under longer repetition conditions, while repetition showed no effect on MMN for patients with schizophrenia.”
From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [28]
Citations
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Sorted by citations
A theory of cortical responses.
Friston, K. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1622 · Cited by 4,578
“Recent advances in the MMN paradigm that use a ‘roving’ paradigm show exactly this (see Baldeweg et al. 2004; see also figure 5).”
BackgroundMethodResultInfluentialThe mismatch negativity (MMN) in basic research of central auditory processing: A review
Näätänen, R., Paavilainen, P., Rinne, T., & Alho, K. (2007) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.04.026 · Cited by 2,644
“In addition, the MMN amplitude gets larger with the increasing number of standards preceding a deviant (Sams et al., 1983; Imada et al., 1993a,b; Baldeweg et al., 2004; Haenschel et al., 2005; Javitt et al., 1998).”
BackgroundMethodThe mismatch negativity: a review of underlying mechanisms
Garrido, M. I., Kilner, J. M., Stephan, K. E., & Friston, K. J. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2008.11.029 · Cited by 1,441
“Moreover, individual MMN amplitudes correlate with disease severity and cognitive dysfunction (Baldeweg et al., 2004) and functional status (Light and Braff, 2005), although there are conflicting reports about its association with genetic risk for schizophrenia (Michie et al., 2002; Bramon et al.,…”
BackgroundInfluentialSynaptic plasticity and dysconnection in schizophrenia
Stephan, K. E., Baldeweg, T., & Friston, K. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.005 · Cited by 841
“Moreover, individual MMN correlates well with disease severity and cognitive dysfunction (Baldeweg et al 2004) and functional status (Light and Braff 2005).”
BackgroundCognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment
McCutcheon, R. A., Keefe, R. S. E., & McGuire, P. K. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01949-9 · Cited by 861
“Furthermore, reduced mismatch negativity (an EEG-detectable response to surprising stimuli) is a marker of cortical disinhibition [248, 249], and is observed in psychosis where it is associated with cognitive symptoms [250 – 254].”
Background
Metadata
- Authors
- Baldeweg, T., Klugman, A., Gruzelier, J., & Hirsch, S. R.
- Affiliations
- Great Ormond Street Hospital (GB)
- Charing Cross Hospital (GB)
- Corresponding author
- Baldeweg, Torsten
- ORCID
- Baldeweg, Torsten
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 69
- Issue
- 2-3
- Pages
- 203-217
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2142009972
- Cited by
- 321
- References
- 64
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 19 · 2023: 12 · 2022: 17 · 2021: 20 · 2020: 27 · 2019: 27 · 2018: 10 · 2017: 16 · 2016: 10 · 2015: 16 · 2014: 16 · 2013: 16 · 2012: 14
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- mismatch negativity, schizophrenia
- MeSH terms
- Acoustic Stimulation, Adult, Brain Mapping, Cognition, Cognition Disorders, Contingent Negative Variation, Electroencephalography, Electrooculography, Evoked Potentials, Auditory, Female, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Schizophrenia, Case-Control Studies
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