Cited by 144Schizophrenia research and treatmentGlobal Cancer Incidence and ScreeningPsychopathy, Forensic Psychiatry, Sexual Offending

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Risk for cancer in a cohort of patients hospitalized for schizophrenia in Denmark, 1969–1993

Dalton, Susanne Oksbjerg, Mellemkjær, Lene, Thomassen, Lars, Mortensen, Preben B., Johansen, Christoffer·2005·Schizophrenia Research

DOI 10.1016/j.schres.2004.11.009

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Abstract

We investigated the cancer risk of patients hospitalized for schizophrenia in a nationwide cohort study. All 22766 adults admitted for schizophrenia, ICD-8 295, in Denmark between 1969 and 1993 were followed up for cancer through 1995. The incidence of site-specific cancers was compared with national incidence rates, adjusted for sex, age and calendar time. The risk for cancer was increased for both men and women during the first year of follow-up. When the first year of follow-up was excluded, the risk for all tobacco-associated cancers and for prostate and rectal cancers was reduced for male patients with schizophrenia. The standardized incidence ratio (SIR) of lung cancer was marginally reduced (SIR, 0.86; 95% CI: 0.65, 1.02) for male patients with schizophrenia; this was due, however, to a reduction in risk for older patients. An increased risk for breast cancer found for female patients with schizophrenia (SIR, 1.20; 95% CI: 1.05, 1.38) should be interpreted with caution, given the high proportion of nulliparous women with schizophrenia in Denmark. The data might support reduced risks for prostate and rectal cancer among male patients with schizophrenia, whereas a changing smoking pattern might explain the reduced risk for tobacco-related cancers.

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Authors: Dalton, S. O., Mellemkjær, L., Thomassen, L., Mortensen, P. B., & Johansen, C.
Affiliations: Danish Cancer Society (DK)
Aarhus University (DK)
Corresponding author: Dalton, Susanne Oksbjerg
ORCID: Dalton, Susanne Oksbjerg
Mellemkjær, Lene
Thomassen, Lars
Mortensen, Preben B.
Johansen, Christoffer
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2005-06
Volume: 75
Issue: 2-3
Pages: 315-324
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2004.11.009
OpenAlex: W2090248954
Cited by: 142
References: 32
Citations by year: 2026: 2 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 7 · 2016: 2 · 2015: 11 · 2014: 6 · 2013: 6 · 2012: 10
FWCI: 1.67
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Schizophrenia Research (publishedVersion)
PubMed (publishedVersion)
Funders: Danmarks Grundforskningsfond
Fonds National de la Recherche Luxembourg
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords: schizophrenia, cancer risk
MeSH terms: Adolescent, Adult, Aged, Denmark, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasms, Risk Factors, Schizophrenia, Cohort Studies, Incidence

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Risk for cancer in a cohort of patients hospitalized for schizophrenia in Denmark, 1969–1993

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