Cancer risk among users of neuroleptic medication: a population-based cohort study
Open accessAbstract
It has been suggested that neuroleptic medication may decrease cancer risk. We compared cancer risks in a population-based cohort study of 25,264 users (>or=2 prescriptions) of neuroleptic medications in the county of North Jutland, Denmark, during 1989-2002, with that of county residents who did not receive such prescriptions. Statistical analyses were based on age-standardisation and Poisson regression analysis, adjusting for age, calendar period, COPD, liver cirrhosis or alcoholism, use of NSAID, and, for breast cancer, additionally for use of hormone therapy, age at first birth, and number of children. Use of neuroleptic medications was associated with a decreased risk for rectal cancer in both women and men (adjusted IRRs of 0.61 (95% confidence interval, 0.41-0.91) and 0.82 (0.56-1.19), respectively) and for colon cancer in female users (0.78; 0.62-0.98). Some risk reduction was seen for prostate cancer (0.87; 0.69-1.08), but breast cancer risk was close to unity (0.93; 0.74-1.17). Overall, treatment with neuroleptic medications was not related to a reduced risk of cancer, but for cancers of the rectum, colon and prostate there were suggestive decreases in risk.
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The majority of studies investigating the risk of breast cancer in patients treated with conventional antipsychotics did not uncover an increased risk of breast cancer, with an exception being the cohort study by Wang et al.
“The majority of the studies in which the risk of breast cancer has been investigated in patients treated with conventional AP (465-468) did not uncover an increased risk of breast cancer, an exception being the cohort study by Wang et al (469).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [468]
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- Authors
- Dalton, S. O., Johansen, C., Poulsen, A. H., Nørgaard, M., Sørensen, H. T., McLaughlin, J. K., Mortensen, P. B., & Friis, S.
- Affiliations
- Danish Cancer Society (DK)
- Aarhus University Hospital (DK)
- International Epidemiology Institute (US)
- Aarhus University (DK)
- Corresponding author
- Dalton, S O
- Venue
- British Journal of Cancer
- Published
- 2006-08-22
- Volume
- 95
- Issue
- 7
- Pages
- 934-939
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC2360537
- OpenAlex
- W2023544789
- Cited by
- 123
- References
- 38
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 16 · 2021: 5 · 2020: 10 · 2019: 8 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 1 · 2012: 6
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (unspecified)
- Locations
- British Journal of Cancer (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Kræftens Bekæmpelse
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- antipsychotic drugs, cancer risk, rectal cancer, colon cancer, prostate cancer, breast cancer, prescription drug use
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Neoplasms, Risk Factors, Schizophrenia, Antipsychotic Agents, Cohort Studies, Incidence
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