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Cited by 89Cognitive Functions and MemorySchizophrenia research and treatmentDementia and Cognitive Impairment Research

Neuropsychological substrates and everyday functioning implications of prospective memory impairment in schizophrenia

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Twamley, Elizabeth W., Woods, Steven Paul, Zurhellen, Cynthia H., Vertinski, Mary, Narvaez, Jenille M., Mausbach, Brent T., Patterson, Thomas L., Jeste, Dilip V.·2008·Schizophrenia Research
DOI 10.1016/j.schres.2007.10.030PMC PMC2576491
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Abstract

Individuals with schizophrenia demonstrate impairment in prospective memory (ProM), which describes the multifaceted ability to execute a future intention. Despite its clear implications for everyday functioning, the neuropsychological substrates and functional correlates of ProM impairment in schizophrenia remain poorly understood. In this study, the Memory for Intentions Screening Test (MIST), a standardized measure of ProM, was administered to 72 outpatients with schizophrenia or schizoaffective disorder as part of a comprehensive neuropsychological and psychiatric research evaluation. Results showed that ProM was positively correlated with standard clinical tests of attention, working memory, processing speed, learning, and executive functioning, but not delayed recall. In the context of multiple neuropsychological predictors, learning ability was the only domain that independently contributed to ProM. Importantly, better ProM was predictive of higher functional capacity (as measured by the UCSD Performance-Based Skills Assessment-Brief Version), above and beyond the variability explained by demographic and disease factors. Analysis of component processes revealed that event-based ProM, as well as no response (i.e., omission) and task substitution errors were the strongest predictors of everyday functioning. Overall, these findings suggest that ProM impairment in schizophrenia is associated with multiple cognitive substrates, particularly episodic learning deficits, and plays an important role in everyday living skills. Studies regarding the potential effectiveness of ProM-based remediation strategies to improve functional outcomes in schizophrenia are indicated.

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Crossref · 10.1016/j.schres.2007.10.030

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  • In conditions such as schizophrenia, prospective memory is often substantially impaired in addition to the impairments in episodic memory.

    “In conditions such as schizophrenia, prospective memory 49 is often substantially impaired in addition to the impairments in episodic memory described above.”

    From Domains of cognition and their assessment (2019) · cites this paper as [49]

  • Prospective memory is implicated in a variety of functional impairments in people with psychiatric conditions.

    “Prospective memory is implicated in a variety of functional impairments in people with psychiatric conditions. 49”

    From Domains of cognition and their assessment (2019) · cites this paper as [49]

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Authors
Twamley, E. W., Woods, S. P., Zurhellen, C. H., Vertinski, M., Narvaez, J. M., Mausbach, B. T., Patterson, T. L., & Jeste, D. V.
Affiliations
University of California San Diego (US)
Corresponding author
Twamley, Elizabeth W.
ORCID
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2008-11
Volume
106
Issue
1
Pages
42-49
ISSN
0920-9964 (ISSN-L)
DOI
10.1016/j.schres.2007.10.030
PMC
PMC2576491
OpenAlex
W2093232416
Cited by
89
References
46
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 8
FWCI
7.28
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (P30MH080002, K23MH066011, MH066011)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
prospective memory, schizophrenia
MeSH terms
Adult, Aged, Brain, Cognition Disorders, Drug Administration Schedule, Female, Humans, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Schizophrenia, Severity of Illness Index, Antipsychotic Agents, Diagnostic and Statistical Manual of Mental Disorders

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