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Cited by 90Schizophrenia research and treatmentFunctional Brain Connectivity StudiesNeural and Behavioral Psychology Studies

Task-related fronto-striatal functional connectivity during working memory performance in schizophrenia

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Quidé, Yann, Morris, Richard W., Shepherd, Alana M., Rowland, Jesseca E., Green, Melissa J.·2013·Schizophrenia Research
DOI 10.1016/j.schres.2013.08.009
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Abstract

Working memory (WM) deficits and associated brain dysfunction are among the most well replicated candidate endophenotypic processes in schizophrenia. However, previous studies demonstrate inconsistent over- and under-activation of dorsolateral and ventrolateral prefrontal cortices (DLPFC; VLPFC), inferior parietal lobule (IPL) during WM performance, as well as subcortical structures including the striatum, and dysfunctional connectivity among fronto-striatal regions in schizophrenia. However, no previous study has investigated task-related functional connectivity (FC) of DLPFC and striatal regions using a seed-based method; here we employed this method to assess patterns of cortical and subcortical functional connectivity among WM structures during a standard 2-back WM task performed by 28 schizophrenia (SZ) and 28 healthy controls (HC). Initial group comparisons of blood oxygenation level dependent (BOLD) responses during the WM task revealed significantly greater bilateral activity in the striatum in SZ relative to HC, but there was no significant group difference in WM cortical activity (right DLPFC, VLPFC or IPL). Analyses of FC within the cortico-subcortical WM network in the HC group revealed positive performance-related FC between the right DLPFC and the right caudate, and between the right VLPFC and the right IPL; this pattern was absent in SZ. In contrast, SZ patients showed negative performance-related functional connectivity between the left putamen and the right VLPFC. Direct group comparisons in functional connectivity showed significantly greater performance-related FC between the VLPFC and bilateral putamen, as well as unilaterally between the VLPFC and the right IPL, in HC. Results suggest a critical dysfunction of cortico-striatal connectivity underpinning information retrieval for SZ patients during WM performance.

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  • Deficits in flexible updating are consistently linked to fronto-striatal dysfunction in patients.

    “and are consistently linked to fronto-striatal dysfunction in patients [17, 28, 31–33].”

    From Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility (2024) · cites this paper as [33]

    The Discussion (page unavailable) links poor working-memory performance in schizophrenia to reduced putamen–VLPFC connectivity and aberrant striatal activity. It discusses selection of information during memory retrieval, but does not establish a specific deficit in flexible updating or that such deficits are consistently linked to fronto-striatal dysfunction. (LLM, conf=0.85)

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Cited by

Sorted by citations

Authors
Quidé, Y., Morris, R. W., Shepherd, A. M., Rowland, J. E., & Green, M. J.
Affiliations
  • UNSW Sydney (AU)
  • The University of Sydney (AU)
  • Black Dog Institute (AU)
Corresponding author
Green, Melissa J.
ORCID
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2013-11
Volume
150
Issue
2-3
Pages
468-475
ISSN
0920-9964 (ISSN-L)
DOI
10.1016/j.schres.2013.08.009
OpenAlex
W1999092671
Cited by
90
References
8
Citations by year
2026: 3 · 2025: 2 · 2024: 7 · 2023: 3 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 12 · 2018: 9 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 8
FWCI
6.35
Type
journal article
Language
en
Open access
Licence
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
  • UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
Funders
  • Pratt Foundation
  • Ramsay Health Care
  • Australian Schizophrenia Research Bank
  • Medical Research Council
  • Australian Research Council (FT0991511)
  • National Health and Medical Research Council (630471)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
schizophrenia, working memory
MeSH terms
Adult, Analysis of Variance, Brain Mapping, Corpus Striatum, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory Disorders, Memory, Short-Term, Middle Aged, Neural Pathways, Neuropsychological Tests, Oxygen, Schizophrenia

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