Prefrontal cortex and basal ganglia control access to working memory

McNab, Fiona; Klingberg, Torkel

doi:10.1038/nn2024

Cited by 989Neural and Behavioral Psychology StudiesCognitive Abilities and TestingNeural dynamics and brain function

Prefrontal cortex and basal ganglia control access to working memory

McNab, Fiona, Klingberg, Torkel·2008·Nature Neuroscience

DOI 10.1038/nn2024

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Abstract

Our capacity to store information in working memory might be determined by the degree to which only relevant information is remembered. The question remains as to how this selection of relevant items to be remembered is accomplished. Here we show that activity in the prefrontal cortex and basal ganglia preceded the filtering of irrelevant information and that activity, particularly in the globus pallidus, predicted the extent to which only relevant information is stored. The preceding frontal and basal ganglia activity were also associated with inter-individual differences in working memory capacity. These findings reveal a mechanism by which frontal and basal ganglia activity exerts attentional control over access to working memory storage in the parietal cortex in humans, and makes an important contribution to inter-individual differences in working memory capacity.

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The empirical neuroimaging literature has identified several distinct sets of brain areas underlying working-memory performance.
“The empirical neuroimaging literature has bolstered these conceptualizations by identifying several distinct sets of brain areas underlying working-memory performance (13–17).”
From Dynamic reconfiguration of frontal brain networks during executive cognition in humans (2015) · cites this paper as [16]
Network reconfiguration may form a putative neurophysiological mechanism of cognitive flexibility and executive function more generally.
“The specificity of these correlations to the frontal systems suggests that network reconfiguration may form a putative neurophysiological mechanism of cognitive flexibility and executive function more generally (16).”
From Dynamic reconfiguration of frontal brain networks during executive cognition in humans (2015) · cites this paper as [16]

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Authors: McNab, F., & Klingberg, T.
Affiliations: Karolinska Institutet (SE)
Corresponding author: Klingberg, Torkel
ORCID: McNab, Fiona
Klingberg, Torkel
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2007-12-09
Volume: 11
Issue: 1
Pages: 103-107
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn2024
OpenAlex: W1964320082
Cited by: 989
References: 31
Citations by year: 2026: 24 · 2025: 41 · 2024: 40 · 2023: 34 · 2022: 29 · 2021: 61 · 2020: 53 · 2019: 39 · 2018: 62 · 2017: 70 · 2016: 65 · 2015: 63 · 2014: 71 · 2013: 77 · 2012: 65
FWCI: 21.88
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders: Knut och Alice Wallenbergs Stiftelse
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: working memory, prefrontal cortex, basal ganglia, globus pallidus, attentional control, information filtering, individual differences, working memory capacity, parietal cortex, neural activity prediction
MeSH terms: Adult, Basal Ganglia, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neuropsychological Tests, Oxygen, Photic Stimulation, Psychomotor Performance, Prefrontal Cortex

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Prefrontal cortex and basal ganglia control access to working memory

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