Persistent organic pollutants and pregnancy complications

Smarr, Melissa M.; Grantz, Katherine L.; Zhang, Cuilin; Sundaram, Rajeshwari; Maisog, José M.; Barr, Dana Boyd; Louis, Germaine M. Buck

doi:10.1016/j.scitotenv.2016.02.030

Cited by 80Toxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicalsPesticide Exposure and Toxicity

Persistent organic pollutants and pregnancy complications

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Smarr, Melissa M., Grantz, Katherine L., Zhang, Cuilin, Sundaram, Rajeshwari, Maisog, José M., Barr, Dana Boyd, Louis, Germaine M. Buck·2016·Science of The Total Environment

DOI 10.1016/j.scitotenv.2016.02.030PMC PMC7751424

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Abstract

We sought to investigate the relationship between maternal preconception exposures to persistent organic pollutants (POPs) and pregnancy complications, gestational diabetes (GDM) and gestational hypertension. Data from 258 (51%) women with human chorionic gonadotropin (hCG) confirmed pregnancies reaching ≥24weeks gestation, from a prospective cohort of 501 couples who discontinued contraception to attempt pregnancy, were analyzed. Preconception concentrations of 9 organochlorine pesticides (OCPs) and 10 polybrominated diphenyl ethers (PBDEs) were quantified in serum. In separate multiple logistic regression models of self-reported physician diagnosed outcomes: GDM (11%) and gestational hypertension (10%), chemicals were natural log-transformed and rescaled by their standard deviation (SD). Models were adjusted for serum lipids, and then adjusted for age, body mass index, race, and smoking. Models were additionally adjusted for the sum of the remaining POPs in each chemical class. Women's serum concentration of PBDE congener 153 (PBDE-153) was positively associated with an increased odds of GDM per SD increase in log-transformed concentration, for unadjusted (OR=1.36, 95%CI: 1.02-1.81), a priori adjusted (OR=1.38, 95% CI: 1.03-1.86) and with the sum of remaining PBDEs (OR=1.79, 95% CI: 1.18, 2.74) models. Our findings suggest that at environmentally relevant concentrations, maternal exposure to POPs prior to conception may contribute to increased chance of developing GDM.

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Some environmental factors, such as passive smoking and exposure to persistent organic pollutants or endocrine disruptors, might contribute to an increased risk of developing gestational diabetes mellitus.
“Some environmental factors, such as passive smoking156 and exposure to persistent organic pollutants (POP) or endocrine disruptors158,159, might contribute to an increased risk of developing GDM.”
From A global view of hypertensive disorders and diabetes mellitus during pregnancy (2022) · cites this paper as [158]
Environmental factors such as indoor air pollution, passive smoking, POPs and endocrine disruptors might contribute to increased risk of HDP or GDM in pregnancy.
“Given that environmental factors such as indoor air pollution168, passive smoking156, POPs, and endocrine disruptors158,159 might contribute to an increased risk of developing either HDP or GDM in pregnancy”
From A global view of hypertensive disorders and diabetes mellitus during pregnancy (2022) · cites this paper as [158]

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Retracted
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Additional file 4 of Endocrine-disrupting chemicals and the risk of gestational diabetes mellitus: a systematic review and meta-analysis
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Additional file 2 of Endocrine-disrupting chemicals and the risk of gestational diabetes mellitus: a systematic review and meta-analysis
Yan, D., Jiao, Y., Yan, H., Liu, T., Yan, H., & Yuan, J. (2022) · Figshare · doi:10.6084/m9.figshare.19776411
Additional file 5 of Endocrine-disrupting chemicals and the risk of gestational diabetes mellitus: a systematic review and meta-analysis
Yan, D., Jiao, Y., Yan, H., Liu, T., Yan, H., & Yuan, J. (2022) · Figshare · doi:10.6084/m9.figshare.19776423
Additional file 1 of Endocrine-disrupting chemicals and the risk of gestational diabetes mellitus: a systematic review and meta-analysis
Yan, D., Jiao, Y., Yan, H., Liu, T., Yan, H., & Yuan, J. (2022) · Figshare · doi:10.6084/m9.figshare.19776408
Additional file 3 of Endocrine-disrupting chemicals and the risk of gestational diabetes mellitus: a systematic review and meta-analysis
Yan, D., Jiao, Y., Yan, H., Liu, T., Yan, H., & Yuan, J. (2022) · Figshare · doi:10.6084/m9.figshare.19776414
Additional file 1 of Environmental health influences in pregnancy and risk of gestational diabetes mellitus: a systematic review
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Pre-Pregnancy Low-Level Exposures To Persistent Organic Pollutants And Gravid Conditions: The Life Study
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Self-citation
Association between serum concentrations of persistent organic pollutants and gestational diabetes mellitus in primiparous women
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Persistent organic pollutants and gestational diabetes: A multi-center prospective cohort study of healthy US women
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Self-citation
Persistent organic pollutant exposure as a risk factor of gestational diabetes mellitus: A systematic review and meta‐analysis
Kouiti, M., Castillo-Hermoso, M. A., Youlyouz‐Marfak, I., Khan, K. S., Thangaratinam, S., Olmedo‐Requena, R., Zamora, J., & Jiménez‐Moleón, J. J. (2023) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17725 · Cited by 7 · see citing works

Authors: Smarr, M. M., Grantz, K. L., Zhang, C., Sundaram, R., Maisog, J. M., Barr, D. B., & Louis, G. M. B.
Affiliations: National Institutes of Health (US)
Emory University (US)
Corresponding author: Smarr, Melissa M.
ORCID: Smarr, Melissa M.
Grantz, Katherine L.
Zhang, Cuilin
Sundaram, Rajeshwari
Barr, Dana Boyd
Louis, Germaine M. Buck
Venue: Science of The Total Environment
Publisher: Elsevier BV
Published: 2016-05
Volume: 551-552
Pages: 285-291
ISSN: 0048-9697 (ISSN-L)
DOI: 10.1016/j.scitotenv.2016.02.030
PMC: PMC7751424
OpenAlex: W2267762287
Cited by: 80
References: 48
Citations by year: 2026: 3 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 21 · 2021: 11 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 6
FWCI: 3.99
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Science of The Total Environment (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Intramural Research Program of the NICHD (N01-HD-3-3355, N01-HD-3-3356, NOH-HD-3-3358)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
Keywords: persistent organic pollutants, pregnancy complications, gestational diabetes mellitus, gestational hypertension, organochlorine pesticides, polybrominated diphenyl ethers, preconception exposure, maternal serum concentrations, environmental endocrine disruptors
MeSH terms: Adult, Environmental Pollutants, Female, Humans, Hydrocarbons, Chlorinated, Pesticides, Polybrominated Biphenyls, Pregnancy, Pregnancy Complications, Prospective Studies, Maternal Exposure, Halogenated Diphenyl Ethers

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