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Cited by 104Effects and risks of endocrine disrupting chemicalsGestational Diabetes Research and ManagementToxic Organic Pollutants Impact

Endocrine-disrupting chemicals and the risk of gestational diabetes mellitus: a systematic review and meta-analysis

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Yan, Dandan, Jiao, Yang, Yan, Honglin, Liu, Tian, Yan, Hong, Yuan, Jingping·2022·Environmental Health
DOI 10.1186/s12940-022-00858-8PMC PMC9109392
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Abstract

Objective: To conduct a comprehensive systematic review and meta-analysis to estimate the relationship between endocrine-disrupting chemicals (EDCs), including polychlorinated biphenyls (PCBs), poly-brominated diphenyl ethers (PBDEs), phthalates (PAEs), and per- and polyfluoroalkyl substances (PFAS) exposure and risk of gestational diabetes mellitus (GDM). Methods: Relevant studies from their inception to November 2021 were identified by searching EMBASE, PubMed, and Web of Science. The cohort and case–control studies that reported effect size with 95% confidence intervals (CIs) of EDC exposure and GDM were selected. The heterogeneity among the included studies was quantified by I2 statistic. Publication bias was evaluated through the Begg and Egger tests. Results: Twenty-five articles with a total of 23,796 participants were found. Results indicated that exposure to PCBs has a significant influence on the incidence of GDM (OR = 1.14; 95% CI = 1.00-–1.31; n = 8). The risk of GDM was found to be associated with PBDE exposure (OR = 1.32; 95% CI = 1.15–1.53; n = 4). PAEs and PFASs exposure were also positively associated with the risk of GDM, with summary ORs of 1.10 (95% CI = 1.03–1.16; n = 7 for PAEs) and 1.09 (95% CI = 1.02–1.16; n = 11 for PFASs), respectively. When only cohort studies were considered, the summary OR between PCBs exposure and the risk of GDM was 0.99 (95% CI = 0.91–1.09; n = 5). Meanwhile, the summary ORs from cohort studies for PBDEs, PAEs, and PFASs exposure were 1.12 (95% CI = 1.00–1.26; n = 2), 1.08 (95% CI = 1.02–1.15; n = 5), and 1.06 (95% CI = 1.00–1.12; n = 8), respectively. The Beggs and Egger tests did not show publication bias, and the sensitivity analyses did not change the results in this meta-analysis. Conclusion: These results support that exposure to certain EDCs, including PCBs, PBDEs, PAEs, and PFAS, increase the risk of GDM. Further large-sample epidemiologic researches and mechanistic studies are needed to verify the potential relationship and biological mechanisms. These results are of public health significance because the daily EDC exposure is expected to increase the risk of GDM development. Graphical Abstract:

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Cited by

Sorted by citations

Authors
Yan, D., Jiao, Y., Yan, H., Liu, T., Yan, H., & Yuan, J.
Affiliations
  • Renmin Hospital of Wuhan University (CN)
  • Huazhong University of Science and Technology (CN)
Corresponding author
Yuan, Jingping
ORCID
Venue
Environmental Health
Publisher
Springer Science and Business Media LLC
Published
2022-05-16
Volume
21
Issue
1
Pages
53-53
ISSN
1476-069X (ISSN-L)
DOI
10.1186/s12940-022-00858-8
PMC
PMC9109392
OpenAlex
W4280605000
Cited by
104
References
7
Citations by year
2026: 15 · 2025: 31 · 2024: 30 · 2023: 28
FWCI
2.17
Type
journal article
Language
en
Open access
Licence
Locations
  • Environmental Health (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (81973092, 82003490)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords
endocrine disruptors, gestational diabetes mellitus, polychlorinated biphenyls, polybrominated diphenyl ethers, phthalates, per- and polyfluoroalkyl substances, prenatal exposure, maternal exposure, pregnancy outcomes, cohort studies, publication bias, sensitivity analysis, subgroup analysis, maternal age, maternal education, maternal body mass index, maternal smoking
MeSH terms
Environmental Pollutants, Female, Fluorocarbons, Humans, Polychlorinated Biphenyls, Pregnancy, Diabetes, Gestational, Endocrine Disruptors, Halogenated Diphenyl Ethers

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