The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Epithelial stem cells and implications for wound repair
Open accessAbstract
Activation of epithelial stem cells and efficient recruitment of their proliferating progeny plays a critical role in cutaneous wound healing. The reepithelialized wound epidermis hasa mosaic composition consisting of progeny that can be traced back both to epidermal and several types of hair follicle stem cells. The contribution of hair follicle stem cells to wound epidermis is particularly intriguing as it involves lineage identity change from follicular to epidermal. Studies from our laboratory show that hair follicle-fated bulge stem cells commit only transient amplifying epidermal progeny that participate in the initial wound re-epithelialization, but eventually are outcompeted by other epidermal clones and largely disappear after a few months. Conversely, recently described stem cell populations residing in the isthmus portion of hair follicle contribute long-lasting progeny toward wound epidermis and, arguably, give rise to new inter-follicular epidermal stem cells. The role of epithelial stem cells during wound healing is not limited to regenerating stratified epidermis. By studying regenerative response in large cutaneous wounds, our laboratory uncovered that epithelial cells in the center of the wound can acquire greater morphogenetic plasticity and, together with the underlying wound dermis, can engage in an embryonic-like process of hair follicle neogenesis. Future studies should uncover cellular and signaling basis of this remarkable adult wound regeneration phenomenon.
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Cotsarelis, G., Sun, T.-T., & Lavker, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90696-c · Cited by 2,276
Self-citationLgr5 marks cycling, yet long-lived, hair follicle stem cells
Jaks, V., Barker, N., Kasper, M., van Es, J. H., Snippert, H. J., Clevers, H., & Toftgård, R. (2008) · Nature Genetics · doi:10.1038/ng.239 · Cited by 966
A single type of progenitor cell maintains normal epidermis
Clayton, E., Doupé, D. P., Klein, A. M., Winton, D. J., Simons, B. D., & Jones, P. H. (2007) · Nature · doi:10.1038/nature05574 · Cited by 853
A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration
Greco, V., Chen, T., Rendl, M., Schober, M., Pasolli, H. A., Stokes, N., dela Cruz-Racelis, J., & Fuchs, E. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.12.009 · Cited by 800
Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
Snippert, H. J., Haegebarth, A., Kasper, M., Jaks, V., van Es, J. H., Barker, N., van de Wetering, M., van den Born, M., Begthel, H., Vries, R. G., et al. (2010) · Science · doi:10.1126/science.1184733 · Cited by 751
Lu, C. P., Polak, L., Rocha, A. S., Pasolli, H. A., Chen, S.-C., Sharma, N., Blanpain, C., & Fuchs, E. (2012) · Cell · doi:10.1016/j.cell.2012.04.045 · Cited by 301
Ansell, D. M., Kloepper, J. E., Thomason, H. A., Paus, R., & Hardman, M. J. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.291 · Cited by 171
Cited by
Extracellular matrix: A dynamic microenvironment for stem cell niche
Gattazzo, F., Urciuolo, A., & Bonaldo, P. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.01.010 · Cited by 1,294
Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies
Rousselle, P., Braye, F., & Dayan, G. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.06.019 · Cited by 640
Spatial organization within a niche as a determinant of stem-cell fate
Rompolas, P., Mesa, K. R., & Greco, V. (2013) · Nature · doi:10.1038/nature12602 · Cited by 397
Defining stem cell dynamics and migration during wound healing in mouse skin epidermis
Aragona, M., Dekoninck, S., Rulands, S., Lenglez, S., Mascré, G., Simons, B. D., & Blanpain, C. (2017) · Nature Communications · doi:10.1038/ncomms14684 · Cited by 384
Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions
Marshall, C. D., Hu, M. S., Leavitt, T., Barnes, L. A., Lorenz, H. P., & Longaker, M. T. (2018) · Advances in Wound Care · doi:10.1089/wound.2016.0696 · Cited by 326
Metadata
- Authors
- Plikus, M. V., Gay, D. L., Treffeisen, E., Wang, A., Supapannachart, R. J., & Cotsarelis, G.
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 23
- Issue
- 9
- Pages
- 946-953
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W2026151319
- Cited by
- 202
- References
- 7
- FWCI
- 16.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Plikus, M. V., Gay, D. L., Treffeisen, E., Wang, A., Supapannachart, R. J., & Cotsarelis, G. (2012). Epithelial stem cells and implications for wound repair. Seminars in Cell & Developmental Biology. https://doi.org/10.1016/j.semcdb.2012.10.001
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
