Cited by 171Hair Growth and DisordersWound Healing and TreatmentsSkin and Cellular Biology Research

Exploring the “Hair Growth–Wound Healing Connection”: Anagen Phase Promotes Wound Re-Epithelialization

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Ansell, David M., Kloepper, Jennifer E., Thomason, Helen A., Paus, Ralf, Hardman, Matthew J.·2011·Journal of Investigative Dermatology

Abstract

When the skin is damaged, a variety of cell types must migrate, proliferate, and differentiate to reform a functional barrier to the external environment. Recent studies have shown that progenitor cells residing in hair follicles (HFs) are able to contribute to this re-epithelialization of wounds in vivo. However, the influence of the hair cycle on wound healing has not previously been addressed. Here, we have exploited spontaneous postnatal hair-cycle synchronicity in mice to systematically examine the influence of the different hair-cycle stages on murine skin wound healing. We report significant acceleration of healing during the anagen phase of HF cycling in vivo, associated with alterations in epithelial, endothelial, and inflammatory cell types. Intriguingly, gene profiling data reveal a clear correlation between the transcription of genes beneficial for wound healing and those upregulated during the anagen phase of the hair cycle in unwounded skin. These findings, which demonstrate a previously unappreciated association between HF cycling and wound healing, reveal numerous molecular correlates for further investigation.

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Crossref · 10.1038/jid.2010.291

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  • The pattern and stage of hair growth in different regions of mouse skin can significantly affect rates of skin healing in mouse tissue.

    “Indeed, the pattern and stage of hair growth in different regions of the mouse skin can significantly affect rates of skin healing in mouse tissue (114).”

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Authors
Ansell, D. M., Kloepper, J. E., Thomason, H. A., Paus, R., & Hardman, M. J.
Affiliations
  • University of Manchester (GB)
  • University of Lübeck (DE)
Corresponding author
Hardman, Matthew J.
Venue
Journal of Investigative Dermatology
Publisher
Elsevier BV
Published
2011-02
Volume
131
Issue
2
Pages
518-528
ISSN
0022-202X (ISSN-L)
OpenAlex
W2109605961
Cited by
171
References
59
Citations by year
2026: 8 · 2025: 13 · 2024: 11 · 2023: 9 · 2022: 11 · 2021: 11 · 2020: 14 · 2019: 16 · 2018: 16 · 2017: 15 · 2016: 11 · 2015: 5 · 2014: 10 · 2013: 8 · 2012: 8
FWCI
9.15
Type
journal article
Language
en
Open access
Locations
  • Journal of Investigative Dermatology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
Funders
  • Manchester Biomedical Research Centre
  • Biotechnology and Biological Sciences Research Council
Topics
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Keywords
hair cycle, anagen phase, wound healing, re-epithelialization, skin wound healing, gene expression profiling, inflammatory cells, endothelial cells
MeSH terms
Animals, Cell Cycle, Cell Movement, Epithelial Cells, Female, Mice, Inbred C57BL, Regeneration, Skin, Skin Physiological Phenomena, Wound Healing, Hair Follicle, Neovascularization, Physiologic, Models, Animal, Mice

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