Identification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair
Open accessAbstract
Summary Sweat glands are abundant glands of our body and essential for thermoregulation. Like mammary glands, they originate from epidermal progenitors. However, they display few signs of cellular turnover, and whether they have stem cells and tissue regenerative capacity remain largely unexplored. Here we address these issues. Using lineage-tracing, we identify multipotent progenitors in sweat duct that transition to unipotency after developing the sweat gland. In characterizing four adult stem cell populations of glandular skin, we show that they display distinct regenerative capabilities and remain unipotent when healing epidermal, myoepithelial-specific and luminal-specific injuries. We devise purification schemes, isolate and transcriptionally profile progenitors. Exploiting molecular differences between sweat and mammary glands, we show that only some progenitors regain multipotency to produce de novo ductal and glandular structures, but that these can retain their identity even within certain foreign microenvironments. Our findings provide new concepts about glandular stem cells and sweat gland biology.
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SwGs are maintained by stem and progenitor cells within the ducts and coiled glands.
“SwGs are maintained by stem and progenitor cells within the ducts and coiled glands.[ 2 ]”
From Sweat Gland Organoids Originating from Reprogrammed Epidermal Keratinocytes Functionally Recapitulated Damaged Skin (2021) · cites this paper as [2]
The Discussion section “Four Populations of Stem Cells in Adult Pawskin” reports homeostatic turnover in sweat ducts and identifies progenitors in the coiled glands. It also says the glands show little, if any, turnover during normal homeostasis; glandular progenitors proliferated in response to targeted injury. Thus, the source does not establish that progenitors in both compartments actively maintain sweat glands under normal conditions. (LLM, conf=0.84)
Experimental — accuracy not yet measuredFor large wounds, tissue damage often causes an overall reduction in local stem cells, and progenitor cells within residual SwGs show limited regenerative capacities and respond inefficiently to tissue damage cues.
“For large wounds, tissue damage often causes an overall reduction in local stem cells, and progenitor cells within residual SwGs show limited regenerative capacities and respond inefficiently to tissue damage cues.[ 2 ]”
From Sweat Gland Organoids Originating from Reprogrammed Epidermal Keratinocytes Functionally Recapitulated Damaged Skin (2021) · cites this paper as [2]
The Results section, “Adult Sweat Duct But Not Gland Progenitors Contribute to Epidermal Wound Repair” (page not provided), reports that sweat glands remained quiescent during epidermal wound healing, supporting a limited response in that setting. But the paper does not report that large wounds generally reduce local stem-cell numbers; its Results on localized gland damage instead describe robust proliferation of surviving gland cells. (LLM, conf=0.88)
Experimental — accuracy not yet measuredSwGs are derived from an epidermal bud of CK5-expressing progenitors, sharing the same origin as epidermal keratinocytes.
“SwGs are derived from an epidermal bud of CK5‐expressing progenitors,[ 2 , 6 ] sharing the same origin as epidermal keratinocytes that can be readily maintained and propagated in vitro.[ 7 ]”
From Sweat Gland Organoids Originating from Reprogrammed Epidermal Keratinocytes Functionally Recapitulated Damaged Skin (2021) · cites this paper as [2]
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“Importantly, as visualized by the iodine-starch method (Wada 1950; Sato and Sato 1990), sweating was restored several days after terminating the DT treatment (Lu et al. 2012).”
BackgroundMethodInfluentialSelf-citationEccrine Sweat Glands are Major Contributors to Reepithelialization of Human Wounds
Rittié, L., Sachs, D. L., Orringer, J. S., Voorhees, J. J., & Fisher, G. J. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.09.019 · Cited by 154 · see citing works
Stem cell dynamics in the hair follicle niche
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Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer
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“In addition, stem cells exist in many other tissues including the epidermal skin, sweat glands, liver, and stomach (Barker et al., 2010; Huch et al., 2013; Lu et al., 2012; Snippert et al., 2010).”
Fuchs (2016) · doi:10.1016/bs.ctdb.2015.11.033 · Cited by 152 · see citing works
“Using lineage tracing, we first established the existence of multipotent and unipotent progenitors in the sweat glands (Lu et al., 2012).”
BackgroundInfluentialSelf-citationWalmsley, G. G., Maan, Z. N., Wong, V., Duscher, D., Hu, M. S.-M., Zielins, E. R., Wearda, T. L., Muhonen, E. G., McArdle, A., Tevlin, R., et al. (2015) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000000972 · Cited by 152 · see citing works
Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche
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Heterotypic cell–cell communication regulates glandular stem cell multipotency
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Stem cells expand potency and alter tissue fitness by accumulating diverse epigenetic memories
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Self-citation3D Cell Printed Tissue Analogues: A New Platform for Theranostics
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“The regeneration of sweat glands has not been studied in depth due to their low regenerative ability and the unknown induction niches of cellular differentiation [76].”
BackgroundMarkers of Epidermal Stem Cell Subpopulations in Adult Mammalian SkinPreprint
Kretzschmar, K., & Watt, F. M. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a013631 · Cited by 115 · see citing works
“Interestingly, upon skin injury, only SOX-9þ ductal but not glandular progenitors are able to contribute to epidermal wound repair, suggesting a stem cell hierarchy that remains to be explored further (Lu et al. 2012).”
BackgroundInfluentialDynamic stem cell heterogeneity
Krieger, T. G., & Simons, B. D. (2015) · Development · doi:10.1242/dev.101063 · Cited by 118 · see citing works
“Over the past few years, the co-existence of distinct progenitor cell behaviours has been reported across a wide range of tissues, often through genetic lineage-tracing approaches (Challen et al., 2010; Lu et al., 2012; Van Keymeulen et al., 2011).”
BackgroundEpidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells
Liu, S., Zhang, H., & Duan, E. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140610869 · Cited by 110 · see citing works
“On the other hand, the glandular myoepithelial stem cells and the luminal stem cells only contribute to their own lineages, respectively [120].”
BackgroundEmerging nonmetabolic functions of skin fat
Guerrero‐Juarez, C. F., & Plikus, M. V. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.162 · Cited by 110 · see citing works
Yao, B., Wang, R., Wang, Y., Zhang, Y., Hu, T. H., Song, W., Li, Z., Huang, S., & Fu, X. (2020) · Science Advances · doi:10.1126/sciadv.aaz1094 · Cited by 109 · see citing works
“Once stem cells are removed from their microenvironment, their response to environmental cues, phenotype, and functionality could often be altered (4, 5).”
BackgroundScarless wound healing: From development to senescence
Pratsinis, H., Mavrogonatou, E., & Kletsas, D. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.04.011 · Cited by 103 · see citing works
Biofabrication of human skin with its appendages
Hosseini, M., Koehler, K. R., & Shafiee, A. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201626 · Cited by 102 · see citing works
Next generation human skin constructs as advanced tools for drug development
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“Very little is known about the development of SwG, though a recent study using lineage tracing in mice revealed that they are derived from multipotent epidermal basal progenitors.(40) After injury, the skin cannot regenerate these structures, but tissue engineering is now bridging the gap to create these structures in…”
BackgroundSept4/ ARTS Regulates Stem Cell Apoptosis and Skin Regeneration
Fuchs, Y., Brown, S., Gorenc, T., Rodriguez, J., Fuchs, E. V., & Steller, H. (2013) · Science · doi:10.1126/science.1233029 · Cited by 95 · see citing works
Self-citationSalivary gland stem cells: A review of development, regeneration and cancer
Emmerson, E., & Knox, S. M. (2018) · genesis · doi:10.1002/dvg.23211 · Cited by 90 · see citing works
“…populations in multiple epithelial tissues, including the skin (reviewed in Terskikh, Vasiliev, & Vorotelyak, 2012), sweat glands (Leung, Kandyba, Chen, Ruffins, & Kobielak, 2013; Lu et al., 2012), teeth (Seidel et al., 2010), pancreas (Teng et al., 2007), and intestine (Buczacki et al., 2013).”
BackgroundCellular plasticity: 1712 to the present day
Tata, P. R., & Rajagopal, J. (2016) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2016.07.005 · Cited by 93 · see citing works
Sweat gland organoids contribute to cutaneous wound healing and sweat gland regeneration
Diao, J., Liu, J., Wang, S., Chang, M., Wang, X., Guo, B., Yu, Q., Yan, F., Su, Y., & Wang, Y. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1485-5 · Cited by 92 · see citing works
The role of nuclear hormone receptors in cutaneous wound repair
Rieger, S., Zhao, H., Martin, P., Abe, K., & Lisse, T. S. (2014) · Cell Biochemistry and Function · doi:10.1002/cbf.3086 · Cited by 91 · see citing works
Bipotent stem cells support the cyclical regeneration of endometrial epithelium of the murine uterus
Jin, S. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1814597116 · Cited by 93 · see citing works
“1 E–G), which differs from mammary glands (23) and sweat glands (24), which contain a bilayer of distinct epithelial cell types.”
BackgroundPiedrafita, G., Kostiou, V., Wabik, A., Colom, B., Fernández‐Antorán, D., Herms, A., Murai, K., Hall, B. A., & Jones, P. H. (2020) · Nature Communications · doi:10.1038/s41467-020-15258-0 · Cited by 86 · see citing works
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Switching roles: the functional plasticity of adult tissue stem cells
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“For example, HSCs are subject to positive regulation of proliferation and self-renewing cell divisions by oestrogen in female mice.”
Rinkevich, Y., Montoro, D. T., Muhonen, E. G., Walmsley, G. G., Lo, D. D., Hasegawa, M., Januszyk, M., Connolly, A. J., Weissman, I. L., & Longaker, M. T. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410097111 · Cited by 84 · see citing works
“describing separate myoepithelial, luminal, and ductal progenitors within sweat glands (16, 30).”
BackgroundEpidermal Stem Cells in Skin Wound Healing
Li, Y., Zhang, J., Yue, J., Gou, X., & Wu, X. (2017) · Advances in Wound Care · doi:10.1089/wound.2017.0728 · Cited by 83 · see citing works
“If the wound only affects epidermis, basal progenitors within sweat ducts have the ability of selfrepair.(10) However, full-thickness skin wounds, such as severe burns, could cause complete loss of sweat gland regeneration.”
BackgroundCellular and molecular mechanisms of plasticity in cancer
Torborg, S. R., Li, Z., Chan, J. E., & Tammela, T. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.04.007 · Cited by 80 · see citing works
The evolving definition of salivary gland stem cells
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Involvement of Wnt, Eda and Shh at defined stages of sweat gland development
Cui, C.-Y., Yin, M., Sima, J., Childress, V., Michel, M., Piao, Y., & Schlessinger, D. (2014) · Development · doi:10.1242/dev.109231 · Cited by 80 · see citing works
“Sweat gland development starts from an ectodermal placode consisting of K14+ progenitor cells (Lu et al., 2012), as seen for hair follicles (Fuchs, 2007;Millar, 2002).”
BackgroundLiu, N., Huang, S., Yao, B., Xie, J., Wu, X., & Fu, X. (2016) · Scientific Reports · doi:10.1038/srep34410 · Cited by 79 · see citing works
Scarring, stem cells, scaffolds and skin repair
Markeson, D., Pleat, J., Sharpe, J. R., Harris, A. L., Seifalian, A. M., & Watt, S. M. (2013) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1841 · Cited by 77 · see citing works
“The possible existence of sweat gland stem cells has recently been addressed by Lu et al. (2012).”
BackgroundProgress in organ 3D bioprinting
Fan, L., Liu, C., Chen, Q., Ao, Q., Tian, X., Fan, J., Tong, H., & Wang, X. (2018) · International Journal of Bioprinting · doi:10.18063/ijb.v4i1.128 · Cited by 76 · see citing works
Veniaminova, N. A., Vagnozzi, A. N., Kopinke, D., Thy, T., Murtaugh, L. C., Maillard, I. P., Dlugosz, A. A., Reiter, J. F., & Wong, S. Y. (2013) · Development · doi:10.1242/dev.101725 · Cited by 76 · see citing works
“Lu et al. recently characterized the global gene expression of the different sweat gland compartments (Lu et al., 2012), and we re-analyzed their dataset using GEO2R.”
MethodCoates, M., Mariottoni, P. R. C. G. B., Corcoran, D. L., Fradin, H., Jaleel, T., Brown, D. A., Brooks, S. R., Murray, J. C. S., Morasso, M. I., & MacLeod, A. S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216249 · Cited by 74 · see citing works
Ennen, M., Keime, C., Gambi, G., Kieny, A., Coassolo, S., Thibault-Carpentier, C., Margerin-Schaller, F., Davidson, G., Vagne, C., Lipsker, D. M., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0010 · Cited by 73 · see citing works
“Thus, these primers properly discriminated SOX9 and SOX10.”
BackgroundInfluentialCheng, L., Yao, B., Hu, T. H., Cui, X., Shu, X., Tang, S., Wang, R., Wang, Y., Liu, Y., Song, W., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.06.017 · Cited by 73 · see citing works
A melanocyte–melanoma precursor niche in sweat glands of volar skin
Okamoto, N., Aoto, T., Uhara, H., Yamazaki, S., Akutsu, H., Umezawa, A., Nakauchi, H., Miyachi, Y., Saida, T., & Nishimura, E. K. (2014) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12297 · Cited by 75 · see citing works
“As those McSCs are maintained in an immature and quiescent state in the SP, where sweat gland keratinocytes are also maintained in a quiescent state (Lu et al., 2012; Nakamura and Tokura, 2009), both in mice and in humans, the SP seem to provide a special niche microenvironment for a fixed number…”
BackgroundLewis, C. J., Mardaryev, A. N., Poterlowicz, K., Sharova, T. Y., Aziz, A., Sharpe, D. T., Botchkareva, N. V., & Sharov, A. A. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.419 · Cited by 72 · see citing works
Nelson, D. A., Manhardt, C. T., Kamath, V. P., Sui, Y., Santamaría-Pang, A., Can, A., Bello, M. O., Corwin, A. D., Dinn, S. R., Lazare, M., et al. (2013) · Biology Open · doi:10.1242/bio.20134309 · Cited by 72 · see citing works
“Interestingly, lineage analyses in the mammary and sweat glands have demonstrated that early embryonic multipotent progenitor populations transition to multiple distinct restricted progenitor populations later in development to control normal gland homeostasis, but that these cells can revert to a more embryonic or mu…”
BackgroundUsing bioprinting and spheroid culture to create a skin model with sweat glands and hair follicles
Zhang, Y., Enhejirigala, Yao, B., Li, Z., Song, W., Li, J., Zhu, D., Wang, Y., Duan, X., Yuan, X., et al. (2021) · Burns & Trauma · doi:10.1093/burnst/tkab013 · Cited by 69 · see citing works
“Until now, knowledge about the postnatal regeneration of multiple skin appendages has mostly come from studies in animal models [24,31].”
BackgroundMethodReproducible strategy for excisional skin-wound-healing studies in mice
Yampolsky, M., Bachelet, I., & Fuchs, Y. (2023) · Nature Protocols · doi:10.1038/s41596-023-00899-4 · Cited by 78 · see citing works
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Lineage Analysis of Epidermal Stem CellsPreprint
Alcolea, M. P., & Jones, P. H. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015206 · Cited by 65 · see citing works
“Compared with the hair follicle and sebaceous glands, the sweat glands (SG) and the ducts that connect them to the epidermal surface have received scant attention in lineagetracing studies until recently (Lu et al. 2012).”
BackgroundInfluentialTam, J., Wang, Y., Farinelli, W. A., et al. (2013) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0b013e3182a85a36 · Cited by 62 · see citing works
“23,24 In this study, MSTCs were placed randomly into wounds without maintaining the epidermis-side-up orientation of normal skin tissue, which caused pieces of epidermis to be present (improperly) under the skin surface at the 1-week time point.”
MethodStem cells, niches and scaffolds: Applications to burns and wound care
Watt, S. M., & Pleat, J. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.10.012 · Cited by 62 · see citing works
“[91] demonstrated that the murine eccrine”
BackgroundInfluentialCapturing epidermal stemness for regenerative medicine
Barrandon, Y., Grasset, N., Zaffalon, A., Gorostidi, F., Claudinot, S., Droz-Georget, S. L., Nanba, D., & Rochat, A. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.09.011 · Cited by 60 · see citing works
“Lineage tracing experiments and fonctional skin reconstitution assays in the mouse have unambiguously demonstrated that the interfollicular epidermis [24–26], the upper constant region of pelage hair follicles [27–29] and the ducts of sweat glands of the foot pad [30] contain cells with stem cells properties.”
BackgroundA novel organotypic 3D sweat gland model with physiological functionality
Klaka, P., Gruedl, S., Banowski, B., Giesen, M., Sättler, A., Proksch, P., Welss, T., & Förster, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182752 · Cited by 58 · see citing works
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Self-citationThe Role of Adipocytes in Tissue Regeneration and Stem Cell Niches
Shook, B. A., Rivera-Gonzalez, G. C., Ebmeier, S., Grisotti, G., Zwick, R. K., & Horsley, V. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125426 · Cited by 58 · see citing works
“Furthermore, the transplantation of embryonic mammary epithelium, single MG stem cells, or sweat gland epithelial progenitors into WAT is sufficient to induce morphogenesis of the mammary ductal tree (Lu et al. 2012, Sakakura et al. 1982, Stingl et al. 2006).”
BackgroundPereira, D., & Sequeira, I. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.682143 · Cited by 62 · see citing works
Yu, W., Barrett, J. N. P., Tong, J., Lin, M., Marohn, M., Devlin, J. C., Herrera, A. M., Remark, J., Levine, J. P., Liu, P., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.11.010 · Cited by 57 · see citing works
Self-citationBeyond the Niche: Tissue-Level Coordination of Stem Cell Dynamics
O’Brien, L. E., & Bilder, D. H. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122319 · Cited by 55 · see citing works
“Along these lines, it is notable that the intestinal stem cell marker Lrig1 directly associates with E-cadherin in cultured cells and that this association is required for density-dependent proliferative control (Lu et al. 2012b, Powell et al. 2012).”
BackgroundTypes or States? Cellular Dynamics and Regenerative Potential
Adler, C. E., & Alvarado, A. S. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.07.008 · Cited by 54 · see citing works
Ninche, N., Kwak, M., & Ghazizadeh, S. (2020) · Development · doi:10.1242/dev.192807 · Cited by 54 · see citing works
Diversity of Neural Precursors in the Adult Mammalian BrainPreprint
Bonaguidi, M. A., Stadel, R. P., Berg, D. A., Sun, J., Ming, G., & Song, H. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018838 · Cited by 50 · see citing works
Programmable Artificial Skins Accomplish Antiscar Healing with Multiple Appendage Regeneration
Xiong, M., Yang, X., Shi, Z., Xiang, J., Gao, H., Ji, S., Li, Y., Pi, W., Chen, H., Zhang, H., et al. (2024) · Advanced Materials · doi:10.1002/adma.202407322 · Cited by 50 · see citing works
de Oliveira, A. S. L. E., Bloise, G., Moltrasio, C., Coelho, A. V. C., Agrelli, A., de Moura, R. R., Tricarico, P. M., Jamain, S., Marzano, A. V., Crovella, S., et al. (2022) · Biomolecules · doi:10.3390/biom12101371 · Cited by 47 · see citing works
“Finally, sweat glands are believed to regulate epidermal homeostasis and wound repair [100,101].”
BackgroundPoblet, E., Jiménez, F., Escario-Travesedo, E., Hardman, J. A., Hernández, I., Agudo-Mena, J. L., Cabrera, J. J., Nicu, C., & Paus, R. (2018) · British Journal of Dermatology · doi:10.1111/bjd.16436 · Cited by 48 · see citing works
Daszczuk, P., Mazurek, P., Pieczonka, T. D., Olczak, A., Boryń, Ł. M., & Kobielak, K. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.595178 · Cited by 46 · see citing works
Merkel cells are long-lived cells whose production is stimulated by skin injury
Wright, M. C., Logan, G., Bolock, A. M., et al. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.12.020 · Cited by 46 · see citing works
“These progenitor cells maintain the barrier function of the skin and insure that skin appendages such as hair follicles, sebaceous and sweat glands continue to function (Jensen et al., 2009; Lu et al., 2012).”
BackgroundChibly, A. M., Querin, L., Harris, Z. I., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107893 · Cited by 44 · see citing works
“Label retaining cell (LRC) assays have contributed in the past to the identification of progenitors in liver [32], skin [33], sweat gland [34,35], pancreas [36], intestine [37,38], and other tissues [39–43].”
BackgroundKwak, M., & Ghazizadeh, S. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0355 · Cited by 43 · see citing works
Epithelial Stem Cells in Adult Skin
Tadeu, A. M. B., & Horsley, V. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416022-4.00004-4 · Cited by 44 · see citing works
“Furthermore, lineage tracing and EdU pulse-chase experiments were able to show that both sweat gland progenitor cell types participate in repair of the epidermis after wounding but the sweat gland itself remains relatively quiescent throughout the wound repair process (Lu et al., 2012).”
InfluentialReconstitution of full-thickness skin by microcolumn grafting
Tam, J., Wang, Y., Vuong, L. N., et al. (2016) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2174 · Cited by 43 · see citing works
“Adnexal structures are home to stem and progenitor cell populations that are able to regenerate the corresponding structures de novo (Lu et al., 2012; Wu et al., 2014).”
BackgroundSun, X., Xiang, J., Chen, R., Geng, Z., Wang, L., Liu, Y., Ji, S., Chen, H., Li, Y., Zhang, C., et al. (2021) · Advanced Science · doi:10.1002/advs.202103079 · Cited by 42 · see citing works
- Authors
- Lu, C. P., Polak, L., Rocha, A. S., Pasolli, H. A., Chen, S.-C., Sharma, N., Blanpain, C., & Fuchs, E.
- Affiliations
- Rockefeller University (US)
- Université Libre de Bruxelles (BE)
- St. Jude Children's Research Hospital (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Fuchs, Elaine
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 150
- Issue
- 1
- Pages
- 136-150
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3423199
- OpenAlex
- W2075001151
- Semantic Scholar
- 7dfb4094c31fc939d907e8d279a06005bef6d755
- Cited by
- 301
- References
- 35
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 19 · 2023: 20 · 2022: 17 · 2021: 20 · 2020: 18 · 2019: 22 · 2018: 22 · 2017: 19 · 2016: 25 · 2015: 31 · 2014: 29 · 2013: 25 · 2012: 8
- FWCI
- 34.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (2r01ar050452-21)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (K01AR066073, F32AR060654, R01-AR050452)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- sweat glands, sweat ducts, adult stem cells, multipotent progenitors, tissue homeostasis, wound healing, epidermal progenitors, myoepithelial cells, lineage tracing, stem cell purification, gene expression profiling, sweat gland regeneration, microenvironment
- MeSH terms
- Epidermal Cells, Animals, Epidermis, Female, Homeostasis, Humans, Mammary Glands, Animal, Morphogenesis, Sweat Glands, Wound Healing, Principal Component Analysis, Stem Cell Transplantation, Multipotent Stem Cells, Mice, Adult Stem Cells
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