The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions
Open accessAbstract
Significance: Scarring of the skin from burns, surgery, and injury constitutes a major burden on the healthcare system. Patients affected by major scars, particularly children, suffer from long-term functional and psychological problems. Recent Advances: Scarring in humans is the end result of the wound healing process, which has evolved to rapidly repair injuries. Wound healing and scar formation are well described on the cellular and molecular levels, but truly effective molecular or cell-based antiscarring treatments still do not exist. Recent discoveries have clarified the role of skin stem cells and fibroblasts in the regeneration of injuries and formation of scar. Critical Issues: It will be important to show that new advances in the stem cell and fibroblast biology of scarring can be translated into therapies that prevent and reduce scarring in humans without major side effects. Future Directions: Novel therapies involving the use of purified human cells as well as agents that target specific cells and modulate the immune response to injury are currently undergoing testing. In the basic science realm, researchers continue to refine our understanding of the role that particular cell types play in the development of scar.
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Cites
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Human skin wounds: A major and snowballing threat to public health and the economy
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Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies
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The Dynamics of the Skin’s Immune System
Nguyen, A. V., & Soulika, A. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081811 · Cited by 694
Patch repair of deep wounds by mobilized fascia
Correa-Gallegos, D., Jiang, D., Christ, S., Ramesh, P., Ye, H., Wannemacher, J., Kalgudde Gopal, S., Yu, Q., Aichler, M., Walch, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1794-y · Cited by 247
Kusnadi, A., Park, S. H., Yuan, R., Pannellini, T., Giannopoulou, E., Oliver, D., Lu, T., Park-Min, K.-H., & Ivashkiv, L. B. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.005 · Cited by 157
Biofabrication of human skin with its appendages
Hosseini, M., Koehler, K. R., & Shafiee, A. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201626 · Cited by 102
Candidate rejuvenating factor GDF11 and tissue fibrosis: friend or foe?
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Metadata
- Authors
- Marshall, C. D., Hu, M. S., Leavitt, T., Barnes, L. A., Lorenz, H. P., & Longaker, M. T.
- Venue
- Advances in Wound Care
- Publisher
- SAGE Publications
- Published
- 2018-02
- Volume
- 7
- Issue
- 2
- Pages
- 29-45
- ISSN
- 2162-1918 (ISSN-L)
- 2162-1934
- OpenAlex
- W2496323153
- Cited by
- 326
- References
- 126
- FWCI
- 10.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Marshall, C. D., Hu, M. S., Leavitt, T., Barnes, L. A., Lorenz, H. P., & Longaker, M. T. (2018). Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions. Advances in Wound Care. https://doi.org/10.1089/wound.2016.0696
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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