Lipid metabolism in astrocytic structure and function
Open accessAbstract
Astrocytes are the most abundant glial cell in the central nervous system and are involved in multiple processes including metabolic homeostasis, blood brain barrier regulation and neuronal crosstalk. Astrocytes are the main storage point of glycogen in the brain and it is well established that astrocyte uptake of glutamate and release of lactate prevents neuronal excitability and supports neuronal metabolic function. However, the role of lipid metabolism in astrocytes in relation to neuronal support has been until recently, unclear. Lipids play a fundamental role in astrocyte function, including energy generation, membrane fluidity and cell to cell signaling. There is now emerging evidence that astrocyte storage of lipids in droplets has a crucial physiological and protective role in the central nervous system. This pathway links β-oxidation in astrocytes to inflammation, signalling, oxidative stress and mitochondrial energy generation in neurons. Disruption in lipid metabolism, structure and signalling in astrocytes can lead to pathogenic mechanisms associated with a range of neurological disorders.
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Storage and utilization of lipids in lipid droplets in astrocytes are important for astrocyte lipid homeostasis and function.
“Storage and utilization of lipids in LDs in astrocytes are important for astrocyte lipid homeostasis and function (48).”
From Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterol (2023) · cites this paper as [48]
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- Authors
- Lee, J. A., Hall, B., Allsop, J., Alqarni, R., & Allen, S. P.
- Affiliations
- University of Sheffield (GB)
- Corresponding author
- Allen, Scott P.
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 112
- Pages
- 123-136
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W3047522435
- Cited by
- 116
- References
- 18
- Citations by year
- 2026: 18 · 2025: 34 · 2024: 25 · 2023: 23 · 2022: 10 · 2021: 6
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- Locations
- Seminars in Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Funders
- University of Sheffield
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- astrocytes, lipid metabolism, lipid droplets, fatty acid beta-oxidation, membrane fluidity, cell-to-cell signaling, oxidative stress, inflammation, neurological disorders, glycogen storage
- MeSH terms
- Astrocytes, Blood-Brain Barrier, Brain, Central Nervous System, Humans, Membrane Fluidity, Neuroglia, Oxidation-Reduction, Signal Transduction, Lipid Metabolism, Lipid Droplets
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